ENSG00000166598


Homo sapiens

Features
Gene ID: ENSG00000166598
  
Biological name :HSP90B1
  
Synonyms : heat shock protein 90 beta family member 1 / HSP90B1 / P14625
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q23.3
Gene start: 103930107
Gene end: 103953645
  
Corresponding Affymetrix probe sets: 200598_s_at (Human Genome U133 Plus 2.0 Array)   200599_s_at (Human Genome U133 Plus 2.0 Array)   216449_x_at (Human Genome U133 Plus 2.0 Array)   216450_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000299767
Ensembl peptide - ENSP00000450215
Ensembl peptide - ENSP00000492386
Ensembl peptide - ENSP00000477660
Ensembl peptide - ENSP00000446266
Ensembl peptide - ENSP00000446748
NCBI entrez gene - 7184     See in Manteia.
OMIM - 191175
RefSeq - NM_003299
RefSeq Peptide - NP_003290
swissprot - F8W026
swissprot - H0YIV0
swissprot - P14625
swissprot - Q96GW1
swissprot - A0A1W2PRR1
swissprot - V9HWP2
swissprot - F8VPC7
Ensembl - ENSG00000166598
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hsp90b1ENSDARG00000003570Danio rerio
 HSP90B1ENSGALG00000033789Gallus gallus
 P08113ENSMUSG00000020048Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P08238 / HSP90AB1 / heat shock protein 90 alpha family class B member 1ENSG0000009638442
P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1ENSG0000008082442
TRAP1 / Q12931 / TNF receptor associated protein 1ENSG0000012660227


Protein motifs (from Interpro)
Interpro ID Name
 IPR001404  Heat shock protein Hsp90 family
 IPR003594  Histidine kinase/HSP90-like ATPase
 IPR019805  Heat shock protein Hsp90, conserved site
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR020575  Heat shock protein Hsp90, N-terminal
 IPR036890  Histidine kinase/HSP90-like ATPase superfamily
 IPR037196  HSP90, C-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IDA
 biological_processGO:0002224 toll-like receptor signaling pathway TAS
 biological_processGO:0006457 protein folding IEA
 biological_processGO:0006898 receptor-mediated endocytosis TAS
 biological_processGO:0006950 response to stress IEA
 biological_processGO:0015031 protein transport NAS
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway IMP
 biological_processGO:0030970 retrograde protein transport, ER to cytosol IMP
 biological_processGO:0031247 actin rod assembly IDA
 biological_processGO:0034975 protein folding in endoplasmic reticulum TAS
 biological_processGO:0034976 response to endoplasmic reticulum stress TAS
 biological_processGO:0036500 ATF6-mediated unfolded protein response TAS
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0043666 regulation of phosphoprotein phosphatase activity IDA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0051208 sequestering of calcium ion NAS
 biological_processGO:0071318 cellular response to ATP IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus HDA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005789 endoplasmic reticulum membrane IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0030496 midbody IDA
 cellular_componentGO:0031012 extracellular matrix HDA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0034663 endoplasmic reticulum chaperone complex IEA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071682 endocytic vesicle lumen TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003723 RNA binding IDA
 molecular_functionGO:0005509 calcium ion binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IDA
 molecular_functionGO:0050750 low-density lipoprotein particle receptor binding IDA
 molecular_functionGO:0051082 unfolded protein binding IEA


Pathways (from Reactome)
Pathway description
Trafficking and processing of endosomal TLR
Scavenging by Class A Receptors
ATF6 (ATF6-alpha) activates chaperone genes
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Interleukin-4 and Interleukin-13 signaling
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000239732 TLR9 / Q9NR96 / toll like receptor 9  / complex / reaction
 ENSG00000196664 TLR7 / Q9NYK1 / toll like receptor 7  / complex / reaction
 ENSG00000137161 CNPY3 / Q9BT09 / canopy FGF signaling regulator 3  / reaction / complex
 ENSG00000166598 P14625 / HSP90B1 / heat shock protein 90 beta family member 1  / complex






 

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