ENSG00000169738


Homo sapiens

Features
Gene ID: ENSG00000169738
  
Biological name :DCXR
  
Synonyms : DCXR / dicarbonyl and L-xylulose reductase / Q7Z4W1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q25.3
Gene start: 82035136
Gene end: 82037732
  
Corresponding Affymetrix probe sets: 217973_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000462725
Ensembl peptide - ENSP00000463354
Ensembl peptide - ENSP00000464332
Ensembl peptide - ENSP00000464507
Ensembl peptide - ENSP00000464518
Ensembl peptide - ENSP00000303356
Ensembl peptide - ENSP00000462226
Ensembl peptide - ENSP00000462272
NCBI entrez gene - 51181     See in Manteia.
OMIM - 608347
RefSeq - NM_001195218
RefSeq - NM_016286
RefSeq Peptide - NP_001182147
RefSeq Peptide - NP_057370
swissprot - Q7Z4W1
swissprot - J3KRZ4
swissprot - J3KS22
swissprot - J3KSZ5
swissprot - J3QL34
swissprot - J3QRQ2
swissprot - J3QS36
swissprot - J3QS45
Ensembl - ENSG00000169738
  
Related genetic diseases (OMIM): 260800 - [Pentosuria], 260800
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dcxrENSDARG00000079271Danio rerio
 DCXRENSGALG00000002849Gallus gallus
 DcxrENSMUSG00000039450Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DHRS4 / Q9BTZ2 / dehydrogenase/reductase 4ENSG0000015732632
Q92506 / HSD17B8 / hydroxysteroid 17-beta dehydrogenase 8ENSG0000020422830
Q9BPX1 / HSD17B14 / hydroxysteroid 17-beta dehydrogenase 14ENSG0000008707627
DHRS2 / Q13268 / dehydrogenase/reductase 2ENSG0000010086726
CBR4 / Q8N4T8 / carbonyl reductase 4ENSG0000014543926
Q6PKH6 / DHRS4L2 / dehydrogenase/reductase 4 like 2ENSG0000018763025
BDH2 / Q9BUT1 / 3-hydroxybutyrate dehydrogenase 2ENSG0000016403924
HPGD / P15428 / 15-hydroxyprostaglandin dehydrogenaseENSG0000016412023
Q99714 / HSD17B10 / hydroxysteroid 17-beta dehydrogenase 10ENSG0000007250622


Protein motifs (from Interpro)
Interpro ID Name
 IPR002347  Short-chain dehydrogenase/reductase SDR
 IPR020904  Short-chain dehydrogenase/reductase, conserved site
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0005997 xylulose metabolic process IEA
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0006739 NADP metabolic process IEA
 biological_processGO:0019640 glucuronate catabolic process to xylulose 5-phosphate TAS
 biological_processGO:0042732 D-xylose metabolic process IEA
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005634 nucleus HDA
 cellular_componentGO:0005881 cytoplasmic microtubule IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005902 microvillus IEA
 cellular_componentGO:0005903 brush border IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016614 oxidoreductase activity, acting on CH-OH group of donors IEA
 molecular_functionGO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor IDA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0044105 L-xylulose reductase (NAD+) activity IEA
 molecular_functionGO:0050038 L-xylulose reductase (NADP+) activity EXP


Pathways (from Reactome)
Pathway description
Formation of xylulose-5-phosphate
Essential pentosuria


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000169738 DCXR / Q7Z4W1 / dicarbonyl and L-xylulose reductase  / complex






 

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