ENSG00000170027


Homo sapiens

Features
Gene ID: ENSG00000170027
  
Biological name :YWHAG
  
Synonyms : P61981 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma / YWHAG
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q11.23
Gene start: 76326794
Gene end: 76359031
  
Corresponding Affymetrix probe sets: 222985_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000306330
NCBI entrez gene - 7532     See in Manteia.
OMIM - 605356
RefSeq - NM_012479
RefSeq Peptide - NP_036611
swissprot - P61981
Ensembl - ENSG00000170027
  
Related genetic diseases (OMIM): 617665 - Epileptic encephalopathy, early infantile, 56, 617665
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6PC29ENSDARG00000067626Danio rerio
 ywhag2ENSDARG00000071658Danio rerio
 YWHAGENSGALG00000017358Gallus gallus
 YwhagENSMUSG00000051391Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
YWHAH / Q04917 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein etaENSG0000012824587
YWHAZ / P63104 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zetaENSG0000016492474
YWHAB / P31946 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein betaENSG0000016691374
YWHAQ / P27348 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein thetaENSG0000013430869
SFN / P31947 / stratifinENSG0000017579364
YWHAE / P62258 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilonENSG0000010895362


Protein motifs (from Interpro)
Interpro ID Name
 IPR000308  14-3-3 protein
 IPR023409  14-3-3 protein, conserved site
 IPR023410  14-3-3 domain
 IPR036815  14-3-3 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0006469 negative regulation of protein kinase activity NAS
 biological_processGO:0006605 protein targeting IEA
 biological_processGO:0009966 regulation of signal transduction NAS
 biological_processGO:0010389 regulation of G2/M transition of mitotic cell cycle TAS
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0045664 regulation of neuron differentiation IMP
 biological_processGO:0048167 regulation of synaptic plasticity IMP
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0071901 negative regulation of protein serine/threonine kinase activity IEA
 biological_processGO:0097711 ciliary basal body-plasma membrane docking TAS
 biological_processGO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane TAS
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005080 protein kinase C binding IPI
 molecular_functionGO:0005159 insulin-like growth factor receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008426 protein kinase C inhibitor activity NAS
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IEA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000170027 YWHAG / P61981 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma  / complex






 

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