ENSG00000170312


Homo sapiens

Features
Gene ID: ENSG00000170312
  
Biological name :CDK1
  
Synonyms : CDK1 / cyclin dependent kinase 1 / P06493
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q21.2
Gene start: 60778331
Gene end: 60794852
  
Corresponding Affymetrix probe sets: 203213_at (Human Genome U133 Plus 2.0 Array)   203214_x_at (Human Genome U133 Plus 2.0 Array)   210559_s_at (Human Genome U133 Plus 2.0 Array)   231534_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000430665
Ensembl peptide - ENSP00000325970
Ensembl peptide - ENSP00000482996
Ensembl peptide - ENSP00000362915
Ensembl peptide - ENSP00000397973
Ensembl peptide - ENSP00000378699
NCBI entrez gene - 983     See in Manteia.
OMIM - 116940
RefSeq - XM_005270303
RefSeq - NM_001320918
RefSeq - NM_001786
RefSeq - NM_033379
RefSeq Peptide - NP_203698
RefSeq Peptide - NP_001307847
RefSeq Peptide - NP_001777
swissprot - A0A024QZP7
swissprot - A0A024QZJ8
swissprot - A0A087WZZ9
swissprot - P06493
swissprot - E5RIU6
Ensembl - ENSG00000170312
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdk1ENSDARG00000087554Danio rerio
 CDK1ENSGALG00000003085Gallus gallus
 Cdk1ENSMUSG00000019942Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CDK2 / P24941 / cyclin dependent kinase 2ENSG0000012337465
CDK3 / Q00526 / cyclin dependent kinase 3ENSG0000025050665
CDK5 / Q00535 / cyclin dependent kinase 5ENSG0000016488555
CDK6 / Q00534 / cyclin dependent kinase 6ENSG0000010581046
CDK4 / P11802 / cyclin dependent kinase 4ENSG0000013544643
CDK11A / Q9UQ88 / cyclin dependent kinase 11AENSG0000000812842
CDK11B / cyclin dependent kinase 11BENSG0000024833342
CDK10 / Q15131 / cyclin dependent kinase 10ENSG0000018532440


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0000187 activation of MAPK activity TAS
 biological_processGO:0000226 microtubule cytoskeleton organization TAS
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0006260 DNA replication TAS
 biological_processGO:0006281 DNA repair TAS
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007077 mitotic nuclear envelope disassembly TAS
 biological_processGO:0007095 mitotic G2 DNA damage checkpoint IEA
 biological_processGO:0007098 centrosome cycle TAS
 biological_processGO:0007344 pronuclear fusion TAS
 biological_processGO:0007569 cell aging IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0010389 regulation of G2/M transition of mitotic cell cycle TAS
 biological_processGO:0010468 regulation of gene expression IBA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010971 positive regulation of G2/M transition of mitotic cell cycle IMP
 biological_processGO:0014038 regulation of Schwann cell differentiation TAS
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0014075 response to amine IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration TAS
 biological_processGO:0016572 histone phosphorylation IEA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IDA
 biological_processGO:0030261 chromosome condensation IEA
 biological_processGO:0030855 epithelial cell differentiation IEP
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0031145 anaphase-promoting complex-dependent catabolic process TAS
 biological_processGO:0033160 positive regulation of protein import into nucleus, translocation IEA
 biological_processGO:0034501 protein localization to kinetochore IDA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0044772 mitotic cell cycle phase transition IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0045931 positive regulation of mitotic cell cycle IEA
 biological_processGO:0045995 regulation of embryonic development TAS
 biological_processGO:0046686 response to cadmium ion IEA
 biological_processGO:0046688 response to copper ion IEA
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0048678 response to axon injury IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051436 obsolete negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
 biological_processGO:0051437 obsolete positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS
 biological_processGO:0051439 obsolete regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
 biological_processGO:0051445 regulation of meiotic cell cycle IBA
 biological_processGO:0055015 ventricular cardiac muscle cell development IEA
 biological_processGO:0060045 positive regulation of cardiac muscle cell proliferation IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0090166 Golgi disassembly ISS
 biological_processGO:0097711 ciliary basal body-plasma membrane docking TAS
 biological_processGO:1900182 positive regulation of protein localization to nucleus IMP
 biological_processGO:1905448 positive regulation of mitochondrial ATP synthesis coupled electron transport IMP
 cellular_componentGO:0000307 cyclin-dependent protein kinase holoenzyme complex IDA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region HDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion TAS
 cellular_componentGO:0005759 mitochondrial matrix IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005876 spindle microtubule IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0030496 midbody IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0072686 mitotic spindle IDA
 cellular_componentGO:0097125 cyclin B1-CDK1 complex IMP
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001618 virus receptor activity IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004693 cyclin-dependent protein serine/threonine kinase activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008353 RNA polymerase II carboxy-terminal domain kinase activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030332 cyclin binding IDA
 molecular_functionGO:0030544 Hsp70 protein binding IEA
 molecular_functionGO:0035173 histone kinase activity IDA
 molecular_functionGO:0097472 cyclin-dependent protein kinase activity IDA


Pathways (from Reactome)
Pathway description
MAPK3 (ERK1) activation
E2F-enabled inhibition of pre-replication complex formation
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
Golgi Cisternae Pericentriolar Stack Reorganization
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
APC/C:Cdc20 mediated degradation of Cyclin B
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
MASTL Facilitates Mitotic Progression
Resolution of Sister Chromatid Cohesion
Condensation of Prometaphase Chromosomes
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Nuclear Pore Complex (NPC) Disassembly
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Depolymerisation of the Nuclear Lamina
Activation of E2F1 target genes at G1/S
Anchoring of the basal body to the plasma membrane
MAPK6/MAPK4 signaling
Ovarian tumor domain proteases
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Regulation of TP53 Degradation
Mitotic Prophase
Cyclin A/B1/B2 associated events during G2/M transition
G2/M DNA replication checkpoint
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
Transcriptional regulation by RUNX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000101224 CDC25B / P30305 / cell division cycle 25B  / reaction
 ENSG00000134480 CCNH / P51946 / cyclin H  / reaction
 ENSG00000133101 CCNA1 / P78396 / cyclin A1  / complex
 ENSG00000127564 PKMYT1 / Q99640 / protein kinase, membrane associated tyrosine/threonine 1  / reaction
 ENSG00000020426 MNAT1 / P51948 / MNAT1, CDK activating kinase assembly factor  / reaction
 ENSG00000134058 CDK7 / P50613 / cyclin dependent kinase 7  / reaction
 ENSG00000134057 CCNB1 / P14635 / cyclin B1  / complex / reaction
 ENSG00000117399 CDC20 / Q12834 / cell division cycle 20  / reaction / complex
 ENSG00000145386 CCNA2 / P20248 / cyclin A2  / complex
 ENSG00000166483 WEE1 / P30291 / WEE1 G2 checkpoint kinase  / reaction
 ENSG00000157456 CCNB2 / O95067 / cyclin B2  / complex / reaction
 ENSG00000164045 CDC25A / P30304 / cell division cycle 25A  / reaction
 ENSG00000158402 CDC25C / P30307 / cell division cycle 25C  / reaction
 ENSG00000175793 SFN / P31947 / stratifin  / complex / reaction
 ENSG00000069956 MAPK6 / Q16659 / mitogen-activated protein kinase 6  / reaction
 ENSG00000164109 MAD2L1 / Q13257 / mitotic arrest deficient 2 like 1  / reaction / complex
 ENSG00000119638 NEK9 / Q8TD19 / NIMA related kinase 9  / reaction
 ENSG00000154473 BUB3 / O43684 / BUB3, mitotic checkpoint protein  / reaction / complex
 ENSG00000114745 Q9BQQ3 / GORASP1 / golgi reassembly stacking protein 1  / reaction
 ENSG00000167110 GOLGA2 / Q08379 / golgin A2  / reaction
 ENSG00000146670 CDCA5 / Q96FF9 / cell division cycle associated 5  / reaction
 ENSG00000134324 LPIN1 / Q14693 / lipin 1  / reaction
 ENSG00000175073 Q96JH7 / VCPIP1 / valosin containing protein interacting protein 1  / reaction
 ENSG00000138069 RAB1A / P62820 / RAB1A, member RAS oncogene family  / reaction
 ENSG00000156970 BUB1B / O60566 / BUB1 mitotic checkpoint serine/threonine kinase B  / complex / reaction
 ENSG00000111206 FOXM1 / Q08050 / forkhead box M1  / reaction
 ENSG00000062650 WAPL / Q7Z5K2 / WAPL cohesin release factor  / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction
 ENSG00000138768 USO1 / O60763 / USO1 vesicle transport factor  / reaction
 ENSG00000105325 FZR1 / Q9UM11 / fizzy and cell division cycle 20 related 1  / reaction
 ENSG00000136122 BORA / Q6PGQ7 / bora, aurora kinase A activator  / reaction
 ENSG00000169032 MAP2K1 / Q02750 / mitogen-activated protein kinase kinase 1  / reaction
 ENSG00000112029 FBXO5 / Q9UKT4 / F-box protein 5  / reaction
 ENSG00000121892 PDS5A / Q29RF7 / PDS5 cohesin associated factor A  / reaction
 ENSG00000067955 CBFB / Q13951 / core-binding factor beta subunit  / reaction
 ENSG00000124813 RUNX2 / Q13950 / runt related transcription factor 2  / reaction
 ENSG00000137497 NUMA1 / Q14980 / nuclear mitotic apparatus protein 1  / reaction
 ENSG00000160789 LMNA / P02545 / lamin A/C  / reaction
 ENSG00000172943 PHF8 / Q9UPP1 / PHD finger protein 8  / reaction
 ENSG00000120539 MASTL / Q96GX5 / microtubule associated serine/threonine kinase like  / reaction
 ENSG00000135679 MDM2 / Q00987 / MDM2 proto-oncogene  / reaction
 ENSG00000083642 PDS5B / Q9NTI5 / PDS5 cohesin associated factor B  / reaction






 

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