ENSG00000175220


Homo sapiens

Features
Gene ID: ENSG00000175220
  
Biological name :ARHGAP1
  
Synonyms : ARHGAP1 / Q07960 / Rho GTPase activating protein 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: p11.2
Gene start: 46677080
Gene end: 46700615
  
Corresponding Affymetrix probe sets: 202117_at (Human Genome U133 Plus 2.0 Array)   216689_x_at (Human Genome U133 Plus 2.0 Array)   217153_at (Human Genome U133 Plus 2.0 Array)   241419_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000434883
Ensembl peptide - ENSP00000310491
Ensembl peptide - ENSP00000432794
NCBI entrez gene - 392     See in Manteia.
OMIM - 602732
RefSeq - XM_017017720
RefSeq - NM_004308
RefSeq - XM_011520095
RefSeq Peptide - NP_004299
swissprot - Q07960
swissprot - H0YE29
swissprot - E9PNR6
Ensembl - ENSG00000175220
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgap1ENSDARG00000024324Danio rerio
 ARHGAP1ENSGALG00000042357Gallus gallus
 Q5FWK3ENSMUSG00000027247Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRR5-ARHGAP8 / PRR5-ARHGAP8 readthroughENSG0000024840552
P85298 / ARHGAP8 / Rho GTPase activating protein 8ENSG0000024148450
PRUNE2 / Q8WUY3 / prune homolog 2ENSG0000010677218
BNIP2 / Q12982 / BCL2 interacting protein 2ENSG0000014029918
ATCAY / Q86WG3 / ATCAY, caytaxinENSG0000016765417
BNIPL / Q7Z465 / BCL2 interacting protein likeENSG0000016314115


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR001251  CRAL-TRIO lipid binding domain
 IPR008936  Rho GTPase activation protein
 IPR036865  CRAL-TRIO lipid binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IDA
 biological_processGO:0007266 Rho protein signal transduction TAS
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0016197 endosomal transport IMP
 biological_processGO:0033572 transferrin transport IMP
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0098706 ferric iron import across plasma membrane IMP
 biological_processGO:2001136 negative regulation of endocytic recycling IMP
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0010008 endosome membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0097443 sorting endosome IMP
 molecular_functionGO:0005070 SH3/SH2 adaptor activity TAS
 molecular_functionGO:0005096 GTPase activator activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0017137 Rab GTPase binding IPI
 molecular_functionGO:0045296 cadherin binding IDA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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