ENSG00000181163


Homo sapiens

Features
Gene ID: ENSG00000181163
  
Biological name :NPM1
  
Synonyms : NPM1 / nucleophosmin 1 / P06748
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q35.1
Gene start: 171387116
Gene end: 171411137
  
Corresponding Affymetrix probe sets: 200063_s_at (Human Genome U133 Plus 2.0 Array)   221691_x_at (Human Genome U133 Plus 2.0 Array)   221923_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000428755
Ensembl peptide - ENSP00000341168
Ensembl peptide - ENSP00000429485
Ensembl peptide - ENSP00000296930
Ensembl peptide - ENSP00000428647
Ensembl peptide - ENSP00000377408
NCBI entrez gene - 4869     See in Manteia.
OMIM - 164040
RefSeq - XM_011534564
RefSeq - NM_001037738
RefSeq - NM_001355006
RefSeq - NM_002520
RefSeq - NM_199185
RefSeq - XM_005265920
RefSeq Peptide - NP_954654
RefSeq Peptide - NP_001032827
RefSeq Peptide - NP_001341935
RefSeq Peptide - NP_002511
swissprot - A0A0S2Z491
swissprot - E5RGW4
swissprot - A0A140VJQ2
swissprot - P06748
swissprot - E5RI98
swissprot - A0A0S2Z4G7
Ensembl - ENSG00000181163
  
Related genetic diseases (OMIM): 601626 - Leukemia, acute myeloid, somatic, 601626
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 npm1aENSDARG00000014329Danio rerio
 NPM1ENSGALG00000002197Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NPM2 / Q86SE8 / nucleophosmin/nucleoplasmin 2ENSG0000015880624
NPM3 / O75607 / nucleophosmin/nucleoplasmin 3ENSG0000010783320


Protein motifs (from Interpro)
Interpro ID Name
 IPR004301  Nucleoplasmin family
 IPR024057  Nucleoplasmin core domain
 IPR032569  Nucleophosmin, C-terminal
 IPR036824  Nucleoplasmin core domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IDA
 biological_processGO:0006334 nucleosome assembly IDA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006886 intracellular protein transport TAS
 biological_processGO:0006913 nucleocytoplasmic transport TAS
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
 biological_processGO:0007098 centrosome cycle ISS
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0007569 cell aging ISS
 biological_processGO:0008104 protein localization IDA
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0010826 negative regulation of centrosome duplication IMP
 biological_processGO:0016032 viral process IEA
 biological_processGO:0032071 regulation of endodeoxyribonuclease activity IDA
 biological_processGO:0034080 CENP-A containing nucleosome assembly TAS
 biological_processGO:0034644 cellular response to UV IDA
 biological_processGO:0042255 ribosome assembly TAS
 biological_processGO:0043066 negative regulation of apoptotic process NAS
 biological_processGO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation IDA
 biological_processGO:0045727 positive regulation of translation IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046599 regulation of centriole replication IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0051259 protein complex oligomerization IDA
 biological_processGO:0060699 regulation of endoribonuclease activity IDA
 biological_processGO:0060735 regulation of eIF2 alpha phosphorylation by dsRNA IDA
 biological_processGO:1902629 regulation of mRNA stability involved in cellular response to UV IMP
 biological_processGO:1902751 positive regulation of cell cycle G2/M phase transition IDA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005813 centrosome ISS
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0031616 spindle pole centrosome IDA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0032993 protein-DNA complex IDA
 molecular_functionGO:0001047 core promoter binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004860 protein kinase inhibitor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0030957 Tat protein binding IDA
 molecular_functionGO:0033613 activating transcription factor binding IPI
 molecular_functionGO:0042393 histone binding IDA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0043023 ribosomal large subunit binding IDA
 molecular_functionGO:0043024 ribosomal small subunit binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IMP
 molecular_functionGO:0051059 NF-kappaB binding ISS
 molecular_functionGO:0051082 unfolded protein binding ISS


Pathways (from Reactome)
Pathway description
Nuclear import of Rev protein
SUMOylation of transcription cofactors
Deposition of new CENPA-containing nucleosomes at the centromere
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000108424 KPNB1 / Q14974 / karyopherin subunit beta 1  / complex / reaction
 ENSG00000145632 PLK2 / Q9NYY3 / polo like kinase 2  / reaction
 ENSG00000132341 RAN / P62826 / RAN, member RAS oncogene family  / complex / reaction
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / reaction / complex
 ENSG00000184900 SUMO3 / P55854 / small ubiquitin-like modifier 3  / reaction
 ENSG00000137203 P05549 / TFAP2A / transcription factor AP-2 alpha  / reaction / complex
 ENSG00000188612 SUMO2 / P61956 / small ubiquitin-like modifier 2  / reaction






 

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