ENSG00000183853


Homo sapiens

Features
Gene ID: ENSG00000183853
  
Biological name :KIRREL1
  
Synonyms : KIRREL1 / kirre like nephrin family adhesion molecule 1 / Q96J84
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q23.1
Gene start: 157993273
Gene end: 158100262
  
Corresponding Affymetrix probe sets: 220825_s_at (Human Genome U133 Plus 2.0 Array)   225303_at (Human Genome U133 Plus 2.0 Array)   232467_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000357155
Ensembl peptide - ENSP00000352138
Ensembl peptide - ENSP00000353202
Ensembl peptide - ENSP00000357154
NCBI entrez gene - 55243     See in Manteia.
OMIM - 607428
RefSeq - XM_005245305
RefSeq - NM_001286349
RefSeq - NM_018240
RefSeq Peptide - NP_001273278
RefSeq Peptide - NP_060710
swissprot - Q5W0F9
swissprot - Q5W0G0
swissprot - Q96J84
swissprot - B4DN67
Ensembl - ENSG00000183853
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kirrel1aENSDARG00000001634Danio rerio
 kirrel1bENSDARG00000056998Danio rerio
 KIRREL1ENSGALG00000029528Gallus gallus
 KirrelENSMUSG00000041734Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8IZU9 / KIRREL3 / kirre like nephrin family adhesion molecule 3ENSG0000014957144
Q6UWL6 / KIRREL2 / kirre like nephrin family adhesion molecule 2ENSG0000012625936
NPHS1 / O60500 / NPHS1, nephrinENSG0000016127022


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013162  CD80-like, immunoglobulin C2-set
 IPR013783  Immunoglobulin-like fold
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0007588 excretion IEA
 biological_processGO:0030838 positive regulation of actin filament polymerization IEA
 biological_processGO:0031295 T cell costimulation TAS
 biological_processGO:0098609 cell-cell adhesion IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031253 cell projection membrane IEA
 cellular_componentGO:0043198 dendritic shaft IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017022 myosin binding IPI


Pathways (from Reactome)
Pathway description
Nephrin family interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / reaction / complex
 ENSG00000106299 WASL / O00401 / Wiskott-Aldrich syndrome like  / complex / reaction
 ENSG00000161270 NPHS1 / O60500 / NPHS1, nephrin  / complex / reaction
 ENSG00000071051 NCK2 / O43639 / NCK adaptor protein 2  / reaction / complex
 ENSG00000147044 CASK / O14936 / calcium/calmodulin dependent serine protein kinase  / complex / reaction
 ENSG00000051382 P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta  / complex / reaction
 ENSG00000140575 IQGAP1 / P46940 / IQ motif containing GTPase activating protein 1  / reaction / complex
 ENSG00000077522 ACTN2 / P35609 / actinin alpha 2  / complex / reaction
 ENSG00000105647 O00459 / PIK3R2 / phosphoinositide-3-kinase regulatory subunit 2  / complex / reaction
 ENSG00000248746 ACTN3 / Q08043 / actinin alpha 3 (gene/pseudogene)  / reaction / complex
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / reaction / complex
 ENSG00000197694 Q13813 / SPTAN1 / spectrin alpha, non-erythrocytic 1  / reaction / complex
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / reaction / complex
 ENSG00000130402 ACTN4 / O43707 / actinin alpha 4  / reaction / complex
 ENSG00000072110 ACTN1 / P12814 / actinin alpha 1  / complex / reaction
 ENSG00000187391 MAGI2 / Q86UL8 / membrane associated guanylate kinase, WW and PDZ domain containing 2  / complex / reaction
 ENSG00000115306 Q01082 / SPTBN1 / spectrin beta, non-erythrocytic 1  / reaction / complex
 ENSG00000158092 NCK1 / P16333 / NCK adaptor protein 1  / reaction / complex
 ENSG00000198087 CD2AP / Q9Y5K6 / CD2 associated protein  / complex / reaction
 ENSG00000116218 NPHS2 / Q9NP85 / NPHS2, podocin  / complex / reaction






 

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