ENSG00000186051


Homo sapiens

Features
Gene ID: ENSG00000186051
  
Biological name :TAL2
  
Synonyms : Q16559 / TAL2 / TAL bHLH transcription factor 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: q31.2
Gene start: 105662457
Gene end: 105663112
  
Corresponding Affymetrix probe sets: 1553593_a_at (Human Genome U133 Plus 2.0 Array)   231759_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000334547
NCBI entrez gene - 6887     See in Manteia.
OMIM - 186855
RefSeq - NM_005421
RefSeq Peptide - NP_005412
swissprot - Q16559
Ensembl - ENSG00000186051
  
Related genetic diseases (OMIM): 613065 - Leukemia, T-cell acute lymphocytic, somatic, 613065

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tal2ENSDARG00000042041Danio rerio
 TAL2ENSGALG00000023114Gallus gallus
 Tal2ENSMUSG00000028417Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TAL1 / P17542 / TAL bHLH transcription factor 1, erythroid differentiation factorENSG0000016236755
LYL1 / P12980 / LYL1, basic helix-loop-helix family memberENSG0000010490348
SCX / Q7RTU7 / scleraxis bHLH transcription factorENSG0000026042834
Q15672 / TWIST1 / twist family bHLH transcription factor 1ENSG0000012269132
TCF15 / Q12870 / transcription factor 15ENSG0000012587832
Q8WVJ9 / TWIST2 / twist family bHLH transcription factor 2ENSG0000023360832
NHLH1 / Q02575 / nescient helix-loop-helix 1ENSG0000017178631
NHLH2 / Q02577 / nescient helix-loop-helix 2ENSG0000017755131
HAND1 / O96004 / heart and neural crest derivatives expressed 1ENSG0000011319628
HAND2 / P61296 / heart and neural crest derivatives expressed 2ENSG0000016410728


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0009791 post-embryonic development IEA
 biological_processGO:0021794 thalamus development IEA
 biological_processGO:0030901 midbrain development IEA
 biological_processGO:0035264 multicellular organism growth IEA
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0006721 Acute lymphatic leukemia "A form of acute leukemia characterized by excess lympoblasts." [HPO:curators]
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 HP:0010982 Polygenic inheritance "A type of multifactorial inheritance governed by the simultaneous action of many (more than three) gene loci." [HPO:probinson, ISBN:978-0192628961]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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