ENSG00000198898


Homo sapiens

Features
Gene ID: ENSG00000198898
  
Biological name :CAPZA2
  
Synonyms : capping actin protein of muscle Z-line alpha subunit 2 / CAPZA2 / P47755
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q31.2
Gene start: 116811070
Gene end: 116922049
  
Corresponding Affymetrix probe sets: 1569450_at (Human Genome U133 Plus 2.0 Array)   201237_at (Human Genome U133 Plus 2.0 Array)   201238_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000395395
Ensembl peptide - ENSP00000408150
Ensembl peptide - ENSP00000492591
Ensembl peptide - ENSP00000485993
Ensembl peptide - ENSP00000420640
Ensembl peptide - ENSP00000419484
Ensembl peptide - ENSP00000418262
Ensembl peptide - ENSP00000354947
NCBI entrez gene - 830     See in Manteia.
OMIM - 601571
RefSeq - NM_006136
RefSeq Peptide - NP_006127
swissprot - C9J7V0
swissprot - A4D0V4
swissprot - A0A0D9SET8
swissprot - F8W9N7
swissprot - F8WED3
swissprot - C9JUG7
swissprot - P47755
swissprot - C9JCZ4
Ensembl - ENSG00000198898
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CAPZA2ENSGALG00000043437Gallus gallus
 Capza2ENSMUSG00000015733Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CAPZA1 / P52907 / capping actin protein of muscle Z-line alpha subunit 1ENSG0000011648985
CAPZA3 / Q96KX2 / capping actin protein of muscle Z-line alpha subunit 3ENSG0000017793835


Protein motifs (from Interpro)
Interpro ID Name
 IPR002189  F-actin-capping protein subunit alpha
 IPR017865  F-actin capping protein, alpha subunit, conserved site
 IPR037282  F-actin-capping protein subunit alpha/beta


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport TAS
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 biological_processGO:0045087 innate immune response TAS
 biological_processGO:0051016 barbed-end actin filament capping IEA
 biological_processGO:0051693 actin filament capping IEA
 biological_processGO:0065003 protein-containing complex assembly TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005903 brush border IEA
 cellular_componentGO:0008290 F-actin capping protein complex IEA
 cellular_componentGO:0015629 actin cytoskeleton TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030863 cortical cytoskeleton IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
MHC class II antigen presentation
HSP90 chaperone cycle for steroid hormone receptors (SHR)
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
Advanced glycosylation endproduct receptor signaling
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000088986 DYNLL1 / P63167 / dynein light chain LC8-type 1  / complex
 ENSG00000135720 O43237 / DYNC1LI2 / dynein cytoplasmic 1 light intermediate chain 2  / complex
 ENSG00000144635 Q9Y6G9 / DYNC1LI1 / dynein cytoplasmic 1 light intermediate chain 1  / complex
 ENSG00000160307 S100B / P04271 / S100 calcium binding protein B  / reaction / complex
 ENSG00000077380 Q13409 / DYNC1I2 / dynein cytoplasmic 1 intermediate chain 2  / complex
 ENSG00000075624 ACTB / P60709 / actin beta  / complex / reaction
 ENSG00000158560 O14576 / DYNC1I1 / dynein cytoplasmic 1 intermediate chain 1  / complex
 ENSG00000197102 Q14204 / DYNC1H1 / dynein cytoplasmic 1 heavy chain 1  / complex
 ENSG00000077549 CAPZB / P47756 / capping actin protein of muscle Z-line beta subunit  / complex / reaction
 ENSG00000166847 DCTN5 / Q9BTE1 / dynactin subunit 5  / complex
 ENSG00000104671 DCTN6 / O00399 / dynactin subunit 6  / complex
 ENSG00000141429 GALNT1 / Q10472 / polypeptide N-acetylgalactosaminyltransferase 1  / reaction / complex
 ENSG00000204843 DCTN1 / Q14203 / dynactin subunit 1  / complex
 ENSG00000131966 ACTR10 / Q9NZ32 / actin related protein 10 homolog  / complex
 ENSG00000079691 Q5VZK9 / CARMIL1 / capping protein regulator and myosin 1 linker 1  / reaction / complex
 ENSG00000175582 RAB6A / P20340 / RAB6A, member RAS oncogene family  / reaction / complex
 ENSG00000137100 DCTN3 / O75935 / dynactin subunit 3  / complex
 ENSG00000143641 GALNT2 / Q10471 / polypeptide N-acetylgalactosaminyltransferase 2  / reaction / complex
 ENSG00000138107 ACTR1A / P61163 / ARP1 actin related protein 1 homolog A  / complex
 ENSG00000007168 P43034 / PAFAH1B1 / platelet activating factor acetylhydrolase 1b regulatory subunit 1  / complex
 ENSG00000151746 BICD1 / Q96G01 / BICD cargo adaptor 1  / complex / reaction
 ENSG00000132912 DCTN4 / Q9UJW0 / dynactin subunit 4  / complex
 ENSG00000175203 DCTN2 / Q13561 / dynactin subunit 2  / complex
 ENSG00000264364 DYNLL2 / Q96FJ2 / dynein light chain LC8-type 2  / complex






 

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