ENSG00000204713


Homo sapiens

Features
Gene ID: ENSG00000204713
  
Biological name :TRIM27
  
Synonyms : P14373 / TRIM27 / tripartite motif containing 27
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p22.1
Gene start: 28903002
Gene end: 28923989
  
Corresponding Affymetrix probe sets: 210541_s_at (Human Genome U133 Plus 2.0 Array)   212116_at (Human Genome U133 Plus 2.0 Array)   212118_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000366399
Ensembl peptide - ENSP00000400058
Ensembl peptide - ENSP00000366404
NCBI entrez gene - 5987     See in Manteia.
OMIM - 602165
RefSeq - NM_006510
RefSeq Peptide - NP_006501
swissprot - A0A1U9X8R9
swissprot - H0Y551
swissprot - P14373
Ensembl - ENSG00000204713
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q62158ENSMUSG00000021326Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TRIM7 / Q9C029 / tripartite motif containing 7ENSG0000014605438
MEFV / O15553 / MEFV, pyrin innate immunity regulatorENSG0000010331335
Q8WV44 / TRIM41 / tripartite motif containing 41ENSG0000014606334
Q9UDY6 / TRIM10 / tripartite motif containing 10ENSG0000020461331
Q12899 / TRIM26 / tripartite motif containing 26ENSG0000023412731
Q86WT6 / TRIM69 / tripartite motif containing 69ENSG0000018588028
Q9C019 / TRIM15 / tripartite motif containing 15ENSG0000020461028
Q9BVG3 / TRIM62 / tripartite motif containing 62ENSG0000011652526
Q9UPQ4 / TRIM35 / tripartite motif containing 35ENSG0000010422826
Q86XT4 / TRIM50 / tripartite motif containing 50ENSG0000014675525
Q6ZMU5 / TRIM72 / tripartite motif containing 72ENSG0000017723824
Q9BZY9 / TRIM31 / tripartite motif containing 31ENSG0000020461617
Q96A61 / TRIM52 / tripartite motif containing 52ENSG0000018371812
Q86UV7 / TRIM73 / tripartite motif containing 73ENSG0000017880912
Q86UV6 / TRIM74 / tripartite motif containing 74ENSG0000015542812


Protein motifs (from Interpro)
Interpro ID Name
 IPR000315  B-box-type zinc finger
 IPR001841  Zinc finger, RING-type
 IPR001870  B30.2/SPRY domain
 IPR003877  SPRY domain
 IPR003879  Butyrophylin-like, SPRY domain
 IPR006574  SPRY-associated
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR017907  Zinc finger, RING-type, conserved site
 IPR020457  Zinc finger, B-box, chordata
 IPR035791  TRIM27, PRY/SPRY domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0002820 negative regulation of adaptive immune response IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IDA
 biological_processGO:0007283 spermatogenesis TAS
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IMP
 biological_processGO:0032897 negative regulation of viral transcription IDA
 biological_processGO:0034314 Arp2/3 complex-mediated actin nucleation IDA
 biological_processGO:0042147 retrograde transport, endosome to Golgi IDA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045814 negative regulation of gene expression, epigenetic IDA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0051127 positive regulation of actin nucleation IEA
 biological_processGO:0070206 protein trimerization IDA
 biological_processGO:0070534 protein K63-linked ubiquitination IMP
 biological_processGO:0072643 interferon-gamma secretion IMP
 biological_processGO:0090281 negative regulation of calcium ion import IMP
 biological_processGO:1900041 negative regulation of interleukin-2 secretion IMP
 biological_processGO:1902187 negative regulation of viral release from host cell IEA
 cellular_componentGO:0001650 fibrillar center IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0030904 retromer complex IDA
 cellular_componentGO:0031965 nuclear membrane IDA
 molecular_functionGO:0003676 nucleic acid binding TAS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity TAS
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046872 metal ion binding TAS
 molecular_functionGO:0061630 ubiquitin protein ligase activity EXP


Pathways (from Reactome)
Pathway description
SUMOylation of ubiquitinylation proteins
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000171862 PTEN / P60484 / phosphatase and tensin homolog  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   


© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr