ENSG00000214078


Homo sapiens

Features
Gene ID: ENSG00000214078
  
Biological name :CPNE1
  
Synonyms : copine 1 / CPNE1 / Q99829
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: -1
Band: q11.22
Gene start: 35626031
Gene end: 35664956
  
Corresponding Affymetrix probe sets: 206918_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000409794
Ensembl peptide - ENSP00000409305
Ensembl peptide - ENSP00000409955
Ensembl peptide - ENSP00000416962
Ensembl peptide - ENSP00000415597
Ensembl peptide - ENSP00000412806
Ensembl peptide - ENSP00000317257
Ensembl peptide - ENSP00000336945
Ensembl peptide - ENSP00000380584
Ensembl peptide - ENSP00000380585
Ensembl peptide - ENSP00000386067
Ensembl peptide - ENSP00000387434
Ensembl peptide - ENSP00000389662
Ensembl peptide - ENSP00000390141
Ensembl peptide - ENSP00000390626
Ensembl peptide - ENSP00000391483
Ensembl peptide - ENSP00000396069
Ensembl peptide - ENSP00000397638
Ensembl peptide - ENSP00000401915
Ensembl peptide - ENSP00000404355
NCBI entrez gene - 8904     See in Manteia.
OMIM - 604205
RefSeq - NM_152927
RefSeq - NM_001198863
RefSeq - NM_003915
RefSeq - NM_152925
RefSeq - NM_152926
RefSeq - NM_152928
RefSeq Peptide - NP_003906
RefSeq Peptide - NP_690902
RefSeq Peptide - NP_690903
RefSeq Peptide - NP_690904
RefSeq Peptide - NP_690905
RefSeq Peptide - NP_001185792
swissprot - Q5JX44
swissprot - Q5JX45
swissprot - Q5JX52
swissprot - Q5JX53
swissprot - Q5JX54
swissprot - Q5JX55
swissprot - Q5JX56
swissprot - Q5JX57
swissprot - E7EV27
swissprot - E7ENH5
swissprot - B0QZ18
swissprot - F2Z2V0
swissprot - Q5JX58
swissprot - H0Y524
swissprot - Q5JX59
swissprot - Q5JX60
swissprot - Q5JX61
swissprot - A6PVH9
swissprot - Q99829
Ensembl - ENSG00000214078
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cpne1ENSDARG00000075536Danio rerio
 CPNE1ENSGALG00000040856Gallus gallus
 Cpne1ENSMUSG00000074643Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CPNE3 / O75131 / copine 3ENSG0000008571965
CPNE2 / Q96FN4 / copine 2ENSG0000014084857
CPNE7 / Q9UBL6 / copine 7ENSG0000017877352
CPNE4 / Q96A23 / copine 4ENSG0000019635350
CPNE6 / O95741 / copine 6ENSG0000010088449
CPNE5 / Q9HCH3 / copine 5ENSG0000012477249
CPNE8 / Q86YQ8 / copine 8ENSG0000013911749
CPNE9 / Q8IYJ1 / copine family member 9ENSG0000014455046


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR002035  von Willebrand factor, type A
 IPR010734  Copine
 IPR035892  C2 domain superfamily
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006508 proteolysis IMP
 biological_processGO:0006629 lipid metabolic process TAS
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0016192 vesicle-mediated transport TAS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043392 negative regulation of DNA binding IDA
 biological_processGO:0045666 positive regulation of neuron differentiation IMP
 biological_processGO:0046474 glycerophospholipid biosynthetic process TAS
 biological_processGO:0051897 positive regulation of protein kinase B signaling IMP
 biological_processGO:0071277 cellular response to calcium ion IMP
 biological_processGO:1901223 negative regulation of NIK/NF-kappaB signaling IMP
 biological_processGO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway IMP
 biological_processGO:1990138 neuron projection extension IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031965 nuclear membrane IDA
 cellular_componentGO:0035577 azurophil granule membrane TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001786 phosphatidylserine binding IDA
 molecular_functionGO:0004175 endopeptidase activity IDA
 molecular_functionGO:0005215 transporter activity TAS
 molecular_functionGO:0005509 calcium ion binding IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005544 calcium-dependent phospholipid binding TAS
 molecular_functionGO:0042803 protein homodimerization activity IMP
 molecular_functionGO:0051059 NF-kappaB binding IPI


Pathways (from Reactome)
Pathway description
Glycerophospholipid biosynthesis
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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