ENSG00000254087


Homo sapiens

Features
Gene ID: ENSG00000254087
  
Biological name :LYN
  
Synonyms : LYN / LYN proto-oncogene, Src family tyrosine kinase / P07948
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: q12.1
Gene start: 55879813
Gene end: 56014168
  
Corresponding Affymetrix probe sets: 202625_at (Human Genome U133 Plus 2.0 Array)   202626_s_at (Human Genome U133 Plus 2.0 Array)   210754_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000428924
Ensembl peptide - ENSP00000428313
Ensembl peptide - ENSP00000428424
NCBI entrez gene - 4067     See in Manteia.
OMIM - 165120
RefSeq - XM_017013416
RefSeq - NM_001111097
RefSeq - NM_002350
RefSeq - XM_011517529
RefSeq Peptide - NP_002341
RefSeq Peptide - NP_001104567
swissprot - P07948
swissprot - E5RJ37
Ensembl - ENSG00000254087
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lynENSDARG00000067916Danio rerio
 LYNENSGALG00000042321Gallus gallus
 LynENSMUSG00000042228Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HCK / P08631 / HCK proto-oncogene, Src family tyrosine kinaseENSG0000010133670
LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinaseENSG0000018286663
BLK / P51451 / BLK proto-oncogene, Src family tyrosine kinaseENSG0000013657360
YES1 / P07947 / YES proto-oncogene 1, Src family tyrosine kinaseENSG0000017610557
FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinaseENSG0000001081057
FGR / P09769 / FGR proto-oncogene, Src family tyrosine kinaseENSG0000000093855
SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinaseENSG0000019712254
FRK / P42685 / fyn related Src family tyrosine kinaseENSG0000011181647
SRMS / Q9H3Y6 / src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sitesENSG0000012550835
PTK6 / Q13882 / protein tyrosine kinase 6ENSG0000010121334


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR035748  Tyrosine-protein kinase Lyn, SH3 domain
 IPR035852  Tyrosine-protein kinase Lyn, SH2 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001782 B cell homeostasis ISS
 biological_processGO:0001817 regulation of cytokine production ISS
 biological_processGO:0001932 regulation of protein phosphorylation TAS
 biological_processGO:0001933 negative regulation of protein phosphorylation ISS
 biological_processGO:0001934 positive regulation of protein phosphorylation IGI
 biological_processGO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002431 Fc receptor mediated stimulatory signaling pathway IBA
 biological_processGO:0002513 tolerance induction to self antigen TAS
 biological_processGO:0002553 histamine secretion by mast cell IEA
 biological_processGO:0002576 platelet degranulation IBA
 biological_processGO:0002762 negative regulation of myeloid leukocyte differentiation IEA
 biological_processGO:0002768 immune response-regulating cell surface receptor signaling pathway TAS
 biological_processGO:0002774 Fc receptor mediated inhibitory signaling pathway ISS
 biological_processGO:0002902 regulation of B cell apoptotic process IBA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus IDA
 biological_processGO:0006991 response to sterol depletion IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IMP
 biological_processGO:0007417 central nervous system development IBA
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0008284 positive regulation of cell proliferation ISS
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0009725 response to hormone ISS
 biological_processGO:0009743 response to carbohydrate IEA
 biological_processGO:0010976 positive regulation of neuron projection development IMP
 biological_processGO:0014003 oligodendrocyte development IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0030218 erythrocyte differentiation ISS
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030889 negative regulation of B cell proliferation IBA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0031295 T cell costimulation TAS
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway ISS
 biological_processGO:0031668 cellular response to extracellular stimulus IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0033003 regulation of mast cell activation ISS
 biological_processGO:0033628 regulation of cell adhesion mediated by integrin IMP
 biological_processGO:0034136 negative regulation of toll-like receptor 2 signaling pathway ISS
 biological_processGO:0034144 negative regulation of toll-like receptor 4 signaling pathway ISS
 biological_processGO:0034605 cellular response to heat IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0042327 positive regulation of phosphorylation IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein ISS
 biological_processGO:0043200 response to amino acid IEA
 biological_processGO:0043304 regulation of mast cell degranulation IBA
 biological_processGO:0043407 negative regulation of MAP kinase activity ISS
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IEA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045646 regulation of erythrocyte differentiation ISS
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0048013 ephrin receptor signaling pathway TAS
 biological_processGO:0048678 response to axon injury IEA
 biological_processGO:0050663 cytokine secretion IEA
 biological_processGO:0050707 regulation of cytokine secretion IEA
 biological_processGO:0050727 regulation of inflammatory response IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050777 negative regulation of immune response TAS
 biological_processGO:0050853 B cell receptor signaling pathway IEA
 biological_processGO:0050855 regulation of B cell receptor signaling pathway IBA
 biological_processGO:0050861 positive regulation of B cell receptor signaling pathway IEA
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0051272 positive regulation of cellular component movement IDA
 biological_processGO:0051279 regulation of release of sequestered calcium ion into cytosol IEA
 biological_processGO:0060252 positive regulation of glial cell proliferation IEA
 biological_processGO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway IEA
 biological_processGO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway TAS
 biological_processGO:0070304 positive regulation of stress-activated protein kinase signaling cascade IDA
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade ISS
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade ISS
 biological_processGO:0070447 positive regulation of oligodendrocyte progenitor proliferation IEA
 biological_processGO:0070667 negative regulation of mast cell proliferation IBA
 biological_processGO:0070668 positive regulation of mast cell proliferation IMP
 biological_processGO:0071300 cellular response to retinoic acid IMP
 biological_processGO:0090025 regulation of monocyte chemotaxis IMP
 biological_processGO:0090330 regulation of platelet aggregation IBA
 biological_processGO:0097028 dendritic cell differentiation IBA
 biological_processGO:1902532 negative regulation of intracellular signal transduction ISS
 biological_processGO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process IMP
 biological_processGO:2000670 positive regulation of dendritic cell apoptotic process IBA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005758 mitochondrial intermembrane space IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005913 cell-cell adherens junction IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030061 mitochondrial crista IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 cellular_componentGO:0034666 integrin alpha2-beta1 complex IEA
 cellular_componentGO:0042629 mast cell granule IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0045121 membrane raft IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IBA
 molecular_functionGO:0004716 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity TAS
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005161 platelet-derived growth factor receptor binding IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity NAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0043015 gamma-tubulin binding IEA
 molecular_functionGO:0043208 glycosphingolipid binding IEA
 molecular_functionGO:0044325 ion channel binding IPI
 molecular_functionGO:0046875 ephrin receptor binding IPI
 molecular_functionGO:0051219 phosphoprotein binding IEA
 molecular_functionGO:0140031 phosphorylation-dependent protein binding IPI


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
Signaling by SCF-KIT
Regulation of KIT signaling
Cell surface interactions at the vascular wall
FCGR activation
PECAM1 interactions
Fc epsilon receptor (FCERI) signaling
EPH-Ephrin signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated NF-kB activation
CD28 co-stimulation
CTLA4 inhibitory signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
Dectin-2 family
CD209 (DC-SIGN) signaling
CD22 mediated BCR regulation
Cyclin D associated events in G1
Platelet Adhesion to exposed collagen
Regulation of signaling by CBL
Growth hormone receptor signaling
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000187266 EPOR / P19235 / erythropoietin receptor  / complex
 ENSG00000130427 EPO / P01588 / erythropoietin  / complex / reaction
 ENSG00000112964 GHR / P10912 / growth hormone receptor  / reaction / complex
 ENSG00000109458 GAB1 / Q13480 / GRB2 associated binding protein 1  / complex / reaction
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / complex / reaction
 ENSG00000141506 PIK3R5 / Q8WYR1 / phosphoinositide-3-kinase regulatory subunit 5  / complex / reaction
 ENSG00000158869 FCER1G / P30273 / Fc fragment of IgE receptor Ig  / complex / reaction
 ENSG00000088053 GP6 / Q9HCN6 / glycoprotein VI platelet  / complex / reaction
 ENSG00000156299 TIAM1 / Q13009 / T cell lymphoma invasion and metastasis 1  / complex / reaction
 ENSG00000051382 P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta  / reaction / complex
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / reaction / complex
 ENSG00000259384 GH1 / P01241 / growth hormone 1  / reaction / complex
 ENSG00000136487 GH2 / P01242 / growth hormone 2  / reaction / complex
 ENSG00000134215 VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3  / reaction / complex
 ENSG00000099942 CRKL / P46109 / CRK like proto-oncogene, adaptor protein  / complex / reaction
 ENSG00000105851 P48736 / PIK3CG / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma  / complex / reaction
 ENSG00000176884 GRIN1 / Q05586 / glutamate ionotropic receptor NMDA type subunit 1  / reaction / complex
 ENSG00000171608 O00329 / PIK3CD / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta  / reaction / complex
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / complex / reaction
 ENSG00000107263 Q13905 / RAPGEF1 / Rap guanine nucleotide exchange factor 1  / reaction / complex
 ENSG00000160293 VAV2 / P52735 / vav guanine nucleotide exchange factor 2  / complex / reaction
 ENSG00000185950 IRS2 / Q9Y4H2 / insulin receptor substrate 2  / complex
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / complex / reaction
 ENSG00000108947 EFNB3 / Q15768 / ephrin B3  / complex / reaction
 ENSG00000179639 FCER1A / P12319 / Fc fragment of IgE receptor Ia  / complex / reaction
 ENSG00000211898 IGHD / P01880 / immunoglobulin heavy constant delta  / reaction
 ENSG00000012124 CD22 / P20273 / CD22 molecule  / reaction
 ENSG00000211899 IGHM / P01871 / immunoglobulin heavy constant mu  / reaction
 ENSG00000125266 EFNB2 / P52799 / ephrin B2  / reaction / complex
 ENSG00000033327 GAB2 / Q9UQC2 / GRB2 associated binding protein 2  / reaction
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / reaction / complex
 ENSG00000126561 P42229 / STAT5A / signal transducer and activator of transcription 5A  / reaction / complex
 ENSG00000066248 NGEF / Q8N5V2 / neuronal guanine nucleotide exchange factor  / reaction / complex
 ENSG00000065675 PRKCQ / Q04759 / protein kinase C theta  / reaction
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / reaction
 ENSG00000197943 PLCG2 / P16885 / phospholipase C gamma 2  / complex / reaction
 ENSG00000254087 LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinase  / complex
 ENSG00000105369 CD79A / P11912 / CD79a molecule  / reaction
 ENSG00000149534 MS4A2 / Q01362 / membrane spanning 4-domains A2  / complex / reaction
 ENSG00000124181 PLCG1 / P19174 / phospholipase C gamma 1  / reaction / complex
 ENSG00000173757 P51692 / STAT5B / signal transducer and activator of transcription 5B  / reaction / complex
 ENSG00000090776 EFNB1 / P98172 / ephrin B1  / complex / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / reaction / complex
 ENSG00000211891 IGHE / P01854 / immunoglobulin heavy constant epsilon  / complex / reaction
 ENSG00000205846 CLEC6A / Q6EIG7 / C-type lectin domain containing 6A  / reaction
 ENSG00000166523 CLEC4E / Q9ULY5 / C-type lectin domain family 4 member E  / reaction
 ENSG00000141968 VAV1 / P15498 / vav guanine nucleotide exchange factor 1  / reaction / complex
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / complex / reaction
 ENSG00000086730 LAT2 / Q9GZY6 / linker for activation of T cells family member 2  / reaction
 ENSG00000007312 CD79B / P40259 / CD79b molecule  / reaction
 ENSG00000273079 GRIN2B / Q13224 / glutamate ionotropic receptor NMDA type subunit 2B  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   


© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr