ENSG00000260428


Homo sapiens

Features
Gene ID: ENSG00000260428
  
Biological name :SCX
  
Synonyms : Q7RTU7 / scleraxis bHLH transcription factor / SCX
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: q24.3
Gene start: 144266560
Gene end: 144268481
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSP00000476384
NCBI entrez gene - 642658     See in Manteia.
OMIM - 609067
RefSeq - NM_001080514
RefSeq - XM_006716616
RefSeq Peptide - NP_001073983
swissprot - Q7RTU7
Ensembl - ENSG00000260428
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 scxaENSDARG00000035695Danio rerio
 scxbENSDARG00000011635Danio rerio
 ScxENSMUSG00000034161Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TCF15 / Q12870 / transcription factor 15ENSG0000012587854
TAL1 / P17542 / TAL bHLH transcription factor 1, erythroid differentiation factorENSG0000016236728
LYL1 / P12980 / LYL1, basic helix-loop-helix family memberENSG0000010490326
Q15672 / TWIST1 / twist family bHLH transcription factor 1ENSG0000012269126
HAND2 / P61296 / heart and neural crest derivatives expressed 2ENSG0000016410724
HAND1 / O96004 / heart and neural crest derivatives expressed 1ENSG0000011319624
Q8WVJ9 / TWIST2 / twist family bHLH transcription factor 2ENSG0000023360823
NHLH2 / Q02577 / nescient helix-loop-helix 2ENSG0000017755121
NHLH1 / Q02575 / nescient helix-loop-helix 1ENSG0000017178620
TAL2 / Q16559 / TAL bHLH transcription factor 2ENSG0000018605118


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001707 mesoderm formation IEA
 biological_processGO:0001894 tissue homeostasis IEA
 biological_processGO:0001958 endochondral ossification IEA
 biological_processGO:0002062 chondrocyte differentiation IEA
 biological_processGO:0003179 heart valve morphogenesis IEA
 biological_processGO:0003188 heart valve formation IEA
 biological_processGO:0006351 transcription, DNA-templated ISS
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030199 collagen fibril organization IEA
 biological_processGO:0030509 BMP signaling pathway IEA
 biological_processGO:0032967 positive regulation of collagen biosynthetic process IEA
 biological_processGO:0035914 skeletal muscle cell differentiation IEA
 biological_processGO:0035989 tendon development IEA
 biological_processGO:0035990 tendon cell differentiation IEA
 biological_processGO:0035992 tendon formation IEA
 biological_processGO:0035993 deltoid tuberosity development IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048706 embryonic skeletal system development IEA
 biological_processGO:0060008 Sertoli cell differentiation ISS
 biological_processGO:0060325 face morphogenesis IEA
 biological_processGO:0061035 regulation of cartilage development IEA
 biological_processGO:0061036 positive regulation of cartilage development IEA
 biological_processGO:0061056 sclerotome development IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:0071773 cellular response to BMP stimulus IEA
 biological_processGO:2000543 positive regulation of gastrulation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding ISS
 molecular_functionGO:0043425 bHLH transcription factor binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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