MP:0001176 | abnormal lung development | "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931] |
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc Genetic Background: involves: 129P2/OlaHsd * 129/Sv
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MP:0001177 | atelectasis | "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc Genetic Background: involves: 129P2/OlaHsd * 129/Sv
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MP:0001178 | pulmonary hypoplasia | "reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0] |
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc Genetic Background: involves: 129P2/OlaHsd * 129/Sv
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MP:0001404 | no spontaneous movement | "failure to make any change in position or posture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159] |
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc Genetic Background: involves: 129P2/OlaHsd * 129/Sv
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MP:0001544 | abnormal cardiovascular system physiology | "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: G6pdxtm1Luz/G6pdx+ Genetic Background: involves: 129S1/Sv * C57BL/6J
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MP:0001575 | cyanosis | "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159] |
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc Genetic Background: involves: 129P2/OlaHsd * 129/Sv
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MP:0001954 | respiratory distress | "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931] |
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc Genetic Background: involves: 129P2/OlaHsd * 129/Sv
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MP:0002274 | abnormal type I pneumocyte morphology | "any structural anomaly of the epithelial cells lining the alveoli through which gas exchange occurs; these are thin cells with a large surface area" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0] |
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc Genetic Background: involves: 129P2/OlaHsd * 129/Sv
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MP:0002275 | abnormal type II pneumocyte morphology | "any structural anomaly of the epithelial cells lining the alveoli that produce surfactant " [Pathology , 2nd edition:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc Genetic Background: involves: 129P2/OlaHsd * 129/Sv
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MP:0002590 | increased mean corpuscular volume | "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Apptm1b(KOMP)Wtsi/App+ Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics
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MP:0002626 | increased heart rate | "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: G6pdxtm1Luz/G6pdx+ Genetic Background: involves: 129S1/Sv * C57BL/6J
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MP:0003179 | decreased platelet count | "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052] |
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Allelic Composition: Apptm1b(KOMP)Wtsi/App+ Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics
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MP:0003641 | small lung | "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332] |
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc Genetic Background: involves: 129P2/OlaHsd * 129/Sv
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MP:0005385 | cardiovascular system phenotype | |
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Allelic Composition: Apptm1b(KOMP)Wtsi/App+ Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics
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MP:0005561 | increased mean corpuscular hemoglobin | "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Apptm1b(KOMP)Wtsi/App+ Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics
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MP:0005600 | increased ventricle muscle contractility | "greater thant the normal ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
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Allelic Composition: G6pdxtm1Luz/G6pdx+ Genetic Background: involves: 129S1/Sv * C57BL/6J
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MP:0005631 | decreased lung weight | "less than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission] |
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc Genetic Background: involves: 129P2/OlaHsd * 129/Sv
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MP:0009142 | decreased prepulse inhibition | "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apptm1b(KOMP)Wtsi/App+ Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics
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MP:0009431 | decreased fetal weight | "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc Genetic Background: involves: 129P2/OlaHsd * 129/Sv
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MP:0009674 | decreased birth weight | "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"] |
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc Genetic Background: involves: 129P2/OlaHsd * 129/Sv
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MP:0009703 | decreased birth body size | "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc Genetic Background: involves: 129P2/OlaHsd * 129/Sv
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MP:0010025 | decreased total body fat amount | "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apptm1b(KOMP)Wtsi/App+ Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics
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MP:0010813 | abnormal alveolar lamellar body morphology | "any structural anomaly of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc Genetic Background: involves: 129P2/OlaHsd * 129/Sv
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MP:0010825 | abnormal lung saccule morphology | "any structural anomaly of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [GO:0060430, ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc Genetic Background: involves: 129P2/OlaHsd * 129/Sv
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MP:0010993 | decreased surfactant secretion | "decreased production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc Genetic Background: involves: 129P2/OlaHsd * 129/Sv
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MP:0011087 | complete neonatal lethality | "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc Genetic Background: involves: 129P2/OlaHsd * 129/Sv
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MP:0011143 | thick lung-associated mesenchyme | "increased thickness of the mesenchymal cell layer due to delay or failure of the mesenchymal compartment to thin down during the late stages of embryonic lung development" [MGI:anna] |
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc Genetic Background: involves: 129P2/OlaHsd * 129/Sv
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MP:0011148 | decreased mesenchymal cell proliferation involved in lung development | "reduction in the expansion rate of a lung mesenchymal cell population by cell division" [MGI:anna] |
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc Genetic Background: involves: 129P2/OlaHsd * 129/Sv
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