ENSMUSG00000018909


Mus musculus

Features
Gene ID: ENSMUSG00000018909
  
Biological name :Arrb1
  
Synonyms : Arrb1 / Beta-arrestin-1 / Q8BWG8
  
Possible biological names infered from orthology : arrestin beta 1 / P49407
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: E1
Gene start: 99535466
Gene end: 99606771
  
Corresponding Affymetrix probe sets: 10555235 (MoGene1.0st)   1460444_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125056
Ensembl peptide - ENSMUSP00000124483
Ensembl peptide - ENSMUSP00000136963
Ensembl peptide - ENSMUSP00000032995
Ensembl peptide - ENSMUSP00000095866
Ensembl peptide - ENSMUSP00000124351
NCBI entrez gene - 109689     See in Manteia.
MGI - MGI:99473
RefSeq - XM_011241644
RefSeq - NM_177231
RefSeq - NM_178220
RefSeq - XM_006507198
RefSeq - XM_006507199
RefSeq - XM_006507200
RefSeq Peptide - NP_796205
RefSeq Peptide - NP_835738
swissprot - F7DF62
swissprot - J3QNU6
swissprot - E0CYB1
swissprot - Q8BWG8
swissprot - E0CY53
Ensembl - ENSMUSG00000018909
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arrb1ENSDARG00000043241Danio rerio
 ARRB1ENSG00000137486Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Arrb2 / Q91YI4 / Beta-arrestin-2 / P32121* / arrestin beta 2*ENSMUSG0000006021674
Sag / P20443 / S-antigen, retina and pineal gland (arrestin) / P10523* / S-antigen visual arrestin*ENSMUSG0000005605554
Arr3 / Q9EQP6 / Arrestin-C / P36575* / arrestin 3*ENSMUSG0000006089053


Protein motifs (from Interpro)
Interpro ID Name
 IPR000698  Arrestin
 IPR011021  Arrestin-like, N-terminal
 IPR011022  Arrestin C-terminal-like domain
 IPR014753  Arrestin, N-terminal
 IPR014756  Immunoglobulin E-set
 IPR017864  Arrestin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation ISS
 biological_processGO:0002031 G-protein coupled receptor internalization ISO
 biological_processGO:0002092 positive regulation of receptor internalization ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II ISO
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007602 phototransduction IMP
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway IMP
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016567 protein ubiquitination ISO
 biological_processGO:0031397 negative regulation of protein ubiquitination ISO
 biological_processGO:0031398 positive regulation of protein ubiquitination IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity ISO
 biological_processGO:0032092 positive regulation of protein binding IMP
 biological_processGO:0032715 negative regulation of interleukin-6 production ISO
 biological_processGO:0032717 negative regulation of interleukin-8 production ISO
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IMP
 biological_processGO:0034260 negative regulation of GTPase activity IEA
 biological_processGO:0034393 positive regulation of smooth muscle cell apoptotic process IEA
 biological_processGO:0035025 positive regulation of Rho protein signal transduction ISO
 biological_processGO:0035066 positive regulation of histone acetylation ISO
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042699 follicle-stimulating hormone signaling pathway IEA
 biological_processGO:0042981 regulation of apoptotic process IMP
 biological_processGO:0043149 stress fiber assembly ISO
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process ISO
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045746 negative regulation of Notch signaling pathway ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0090240 positive regulation of histone H4 acetylation ISO
 cellular_componentGO:0000785 chromatin ISO
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016604 nuclear body ISO
 cellular_componentGO:0031143 pseudopodium IEA
 cellular_componentGO:0031410 cytoplasmic vesicle ISO
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0005096 GTPase activator activity ISO
 molecular_functionGO:0005159 insulin-like growth factor receptor binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0030331 estrogen receptor binding IEA
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IDA
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0031691 alpha-1A adrenergic receptor binding IEA
 molecular_functionGO:0031692 alpha-1B adrenergic receptor binding IEA
 molecular_functionGO:0031701 angiotensin receptor binding ISO
 molecular_functionGO:0031762 follicle-stimulating hormone receptor binding IEA
 molecular_functionGO:0031896 V2 vasopressin receptor binding IEA
 molecular_functionGO:0035612 AP-2 adaptor complex binding IEA
 molecular_functionGO:0035615 clathrin adaptor activity IEA
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISO
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0045309 protein phosphorylated amino acid binding IEA
 molecular_functionGO:0051219 phosphoprotein binding IEA
 molecular_functionGO:1990763 arrestin family protein binding ISO


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
Thrombin signalling through proteinase activated receptors (PARs)
Activation of SMO
MAP2K and MAPK activation
Ub-specific processing proteases
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0001178 pulmonary hypoplasia "reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
Show

Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0001404 no spontaneous movement "failure to make any change in position or posture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: G6pdxtm1Luz/G6pdx+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0002274 abnormal type I pneumocyte morphology "any structural anomaly of the epithelial cells lining the alveoli through which gas exchange occurs; these are thin cells with a large surface area" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0002275 abnormal type II pneumocyte morphology "any structural anomaly of the epithelial cells lining the alveoli that produce surfactant " [Pathology , 2nd edition:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apptm1b(KOMP)Wtsi/App+
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: G6pdxtm1Luz/G6pdx+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Apptm1b(KOMP)Wtsi/App+
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
Show

Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0005385 cardiovascular system phenotype 
Show

Allelic Composition: Apptm1b(KOMP)Wtsi/App+
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apptm1b(KOMP)Wtsi/App+
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0005600 increased ventricle muscle contractility "greater thant the normal ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: G6pdxtm1Luz/G6pdx+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0005631 decreased lung weight "less than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apptm1b(KOMP)Wtsi/App+
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apptm1b(KOMP)Wtsi/App+
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0010813 abnormal alveolar lamellar body morphology "any structural anomaly of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0010825 abnormal lung saccule morphology "any structural anomaly of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [GO:0060430, ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0010993 decreased surfactant secretion "decreased production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0011143 thick lung-associated mesenchyme "increased thickness of the mesenchymal cell layer due to delay or failure of the mesenchymal compartment to thin down during the late stages of embryonic lung development" [MGI:anna]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0011148 decreased mesenchymal cell proliferation involved in lung development "reduction in the expansion rate of a lung mesenchymal cell population by cell division" [MGI:anna]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001761 Smo / P56726 / smoothened, frizzled class receptor / Q99835*  / complex / reaction
 ENSMUSG00000020888 Dvl2 / Q60838 / Segment polarity DVL-2 / O14641* / dishevelled segment polarity protein 2*  / complex / reaction
 ENSMUSG00000031390 Avpr2 / O88721 / arginine vasopressin receptor 2 / P30518*  / complex / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000048376 F2r / P30558 / Proteinase-activated receptor 1 / P25116* / coagulation factor II thrombin receptor*  / complex / reaction
 ENSMUSG00000018395 Kif3a / P28741 / Kinesin-like protein KIF3A / Q9Y496* / kinesin family member 3A*  / complex / reaction
 ENSMUSG00000045730 Adrb2 / P18762 / Beta-2 adrenergic receptor / P07550* / adrenoceptor beta 2*  / complex / reaction
 ENSMUSG00000037727 Avp / P35455 / arginine vasopressin / P01185*  / reaction / complex
 ENSMUSG00000021994 Wnt5a / P22725 / wingless-type MMTV integration site family, member 5A / P41221* / Wnt family member 5A*  / reaction / complex
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / reaction / complex
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / reaction / complex
 ENSMUSG00000049791 Fzd4 / Q61088 / Frizzled-4 / Q9ULV1* / frizzled class receptor 4*  / complex / reaction
 ENSMUSG00000045613 Chrm2 / Q9ERZ4 / cholinergic receptor, muscarinic 2, cardiac / P08172* / cholinergic receptor muscarinic 2*  / complex / reaction






 

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