ENSMUSG00000074657


Mus musculus

Features
Gene ID: ENSMUSG00000074657
  
Biological name :Kif5a
  
Synonyms : Kif5a / Kinesin heavy chain isoform 5A / P33175
  
Possible biological names infered from orthology : kinesin family member 5A / Q12840
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D3
Gene start: 127225696
Gene end: 127263348
  
Corresponding Affymetrix probe sets: 10373113 (MoGene1.0st)   1427635_at (Mouse Genome 430 2.0 Array)   1434670_at (Mouse Genome 430 2.0 Array)   1450249_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151969
Ensembl peptide - ENSMUSP00000096775
Ensembl peptide - ENSMUSP00000151402
NCBI entrez gene - 16572     See in Manteia.
MGI - MGI:109564
RefSeq - NM_001039000
RefSeq - NM_008447
RefSeq Peptide - NP_001034089
RefSeq Peptide - NP_032473
swissprot - A0A1W2P859
swissprot - P33175
Ensembl - ENSMUSG00000074657
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kif5aaENSDARG00000098936Danio rerio
 kif5abENSDARG00000059818Danio rerio
 KIF5AENSG00000155980Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kif5c / P28738 / Kinesin heavy chain isoform 5C / O60282* / kinesin family member 5C*ENSMUSG0000002676469
Kif5b / Q61768 / Kinesin-1 heavy chain / P33176* / kinesin family member 5B*ENSMUSG0000000674065
Kif21b / kinesin family member 21B / O75037*ENSMUSG0000004164225
Cenpe / centromere protein E / Q02224*ENSMUSG0000004532825
Kif21a / Q9QXL2 / Kinesin-like protein KIF21A / Q7Z4S6* / kinesin family member 21A*ENSMUSG0000002262924
Kif17 / Q99PW8 / Kinesin-like protein KIF17 / Q9P2E2* / kinesin family member 17*ENSMUSG0000002875823
Kif27 / Q7M6Z4 / Kinesin-like protein KIF27 / Q86VH2* / kinesin family member 27*ENSMUSG0000006017623
Kif4 / P33174 / Chromosome-associated kinesin KIF4 / KIF4A* / KIF4B* / Q2VIQ3* / O95239* / kinesin family member 4B* / kinesin family member 4A*ENSMUSG0000003431123
Kif7 / kinesin family member 7 / Q2M1P5*ENSMUSG0000005038223
Kif15 / Q6P9L6 / Kinesin-like protein KIF15 / Q9NS87* / kinesin family member 15*ENSMUSG0000003676822
Kif11 / Q6P9P6 / Kinesin-like protein KIF11 / P52732* / kinesin family member 11*ENSMUSG0000001244322
Kif3b / Q61771 / Kinesin-like protein KIF3B Kinesin-like protein KIF3B, N-terminally processed / O15066* / kinesin family member 3B*ENSMUSG0000002747521
Kif3c / O35066 / Kinesin-like protein KIF3C / O14782* / kinesin family member 3C*ENSMUSG0000002066820
Kif3a / P28741 / Kinesin-like protein KIF3A / Q9Y496* / kinesin family member 3A*ENSMUSG0000001839520


Protein motifs (from Interpro)
Interpro ID Name
 IPR001752  Kinesin motor domain
 IPR019821  Kinesin motor domain, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027640  Kinesin-like protein
 IPR036961  Kinesin motor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0007411 axon guidance IBA
 biological_processGO:0008104 protein localization IBA
 biological_processGO:0016192 vesicle-mediated transport IDA
 biological_processGO:0098971 anterograde dendritic transport of neurotransmitter receptor complex IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005871 kinesin complex TAS
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0032839 dendrite cytoplasm IEA
 cellular_componentGO:0035253 ciliary rootlet IDA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003777 microtubule motor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IDA
 molecular_functionGO:0008574 ATP-dependent microtubule motor activity, plus-end-directed IBA
 molecular_functionGO:0019894 kinesin binding IPI


Pathways (from Reactome)
Pathway description
MHC class II antigen presentation
RHO GTPases activate KTN1
COPI-dependent Golgi-to-ER retrograde traffic
Kinesins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gli3Pdn/Gli3+
Genetic Background: involves: Jcl:ICR

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gli3Pdn/Gli3+
Genetic Background: involves: Jcl:ICR

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Gli3Pdn/Gli3+
Genetic Background: involves: Jcl:ICR

 MP:0000951 sporadic seizures "occasional seizures occuring at irregular intervals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gli3Pdn/Gli3+
Genetic Background: involves: Jcl:ICR

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gli3Pdn/Gli3+
Genetic Background: involves: Jcl:ICR

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Gli3Pdn/Gli3+
Genetic Background: involves: Jcl:ICR

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Gli3Pdn/Gli3+
Genetic Background: involves: Jcl:ICR

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gli3Pdn/Gli3+
Genetic Background: involves: Jcl:ICR

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: Gli3Pdn/Gli3+
Genetic Background: involves: Jcl:ICR

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Gli3Pdn/Gli3+
Genetic Background: involves: Jcl:ICR

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kif5atm1.1Noh/Kif5atm1.1Noh
Genetic Background: B6.129S6-Kif5atm1.1Noh

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
Show

Allelic Composition: Gli3Pdn/Gli3+
Genetic Background: involves: Jcl:ICR

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kif5atm1.1Noh/Kif5atm1.1Noh
Genetic Background: B6.129S6-Kif5atm1.1Noh

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gli3Pdn/Gli3+
Genetic Background: involves: Jcl:ICR

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kif5atm1.1Noh/Kif5atm1.1Noh
Genetic Background: B6.129S6-Kif5atm1.1Noh

 MP:0004008 abnormal GABA receptor currents "change in the measured amplitude or duration of response to stimulation of GABA receptors" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Kif5atm1.1Noh/Kif5atm1.1Noh
Genetic Background: B6.129S6-Kif5atm1.1Noh

 MP:0004768 abnormal axonal transport "any functional anomaly of the directed movement of organelles or vesicles along microtubules in nerve cell axons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gli3Pdn/Gli3+
Genetic Background: involves: Jcl:ICR

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gli3Pdn/Gli3+
Genetic Background: involves: Jcl:ICR

 MP:0008469 abnormal protein level "anomaly in the amount of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gli3Pdn/Gli3+
Genetic Background: involves: Jcl:ICR

 MP:0008546 abnormal vesicle-mediated transport "anomaly in the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell" [GO:0016192]
Show

Allelic Composition: Foxo3mommeR1/Foxo3tm1.1Rdp,Tg(HBA1-Gfp)1Ew/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ

 MP:0009435 abnormal miniature inhibitory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an inhibitory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kif5atm1.1Noh/Kif5atm1.1Noh
Genetic Background: B6.129S6-Kif5atm1.1Noh

 MP:0011084 partial lethality at weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms at weaning age" [MGI:csmith]
Show

Allelic Composition: Gli3Pdn/Gli3+
Genetic Background: involves: Jcl:ICR

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Kif5atm1.1Noh/Kif5atm1.1Noh
Genetic Background: B6.129S6-Kif5atm1.1Noh

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Gli3Pdn/Gli3+
Genetic Background: involves: Jcl:ICR

Allelic Composition: Kif5atm1.1Noh/Kif5atm1.1Noh
Genetic Background: B6.129S6-Kif5atm1.1Noh

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / reaction / complex
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction / complex
 ENSMUSG00000073982 Rhog / P84096 / ras homolog family member G / P84095*  / complex / reaction
 ENSMUSG00000074657 Kif5a / P33175 / Kinesin heavy chain isoform 5A / Q12840* / kinesin family member 5A*  / reaction / complex
 ENSMUSG00000024862 Klc2 / kinesin light chain 2 / Q9H0B6*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   


© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr