GO:0036317:   tyrosyl-RNA phosphodiesterase activity
Catalysis of the hydrolysis of a 5" tyrosyl-RNA phosphodiester bond between a protein and RNA. In picornaviruses, this covalent bond connects VPg, a viral-encoded protein essential for RNA replication, to the 5" end of all nascent picornavirus genomes; it is cleaved from viral RNA prior to its engaging in protein synthesis.