100102


Mus musculus (NCBI)

Features
Gene ID: 100102
  
Biological name :
  
Synonyms : AI415265|AI747682|FH3|HCHOLA3|Narc1|PC9 / Pcsk9 / proprotein convertase subtilisin/kexin type 9
  
Possible biological names infered from orthology :
  
Species: Mus musculus (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1437453_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: RefSeq - 23956352
RefSeq - NC_000070.6
RefSeq - NP_705793.1
RefSeq - NM_153565.2
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSMUSG00000044254 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IEP
 biological_processGO:0001889 liver development IEP
 biological_processGO:0001920 negative regulation of receptor recycling ISO
 biological_processGO:0002092 positive regulation of receptor internalization ISO
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006641 triglyceride metabolic process IDA
 biological_processGO:0006644 phospholipid metabolic process IDA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007041 lysosomal transport ISO
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IDA
 biological_processGO:0009267 cellular response to starvation ISO
 biological_processGO:0010469 regulation of signaling receptor activity ISO
 biological_processGO:0010989 negative regulation of low-density lipoprotein particle clearance ISO
 biological_processGO:0016485 protein processing ISO
 biological_processGO:0016540 protein autoprocessing ISS
 biological_processGO:0022008 neurogenesis IEP
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0032799 low-density lipoprotein receptor particle metabolic process IDA
 biological_processGO:0032802 low-density lipoprotein particle receptor catabolic process ISS
 biological_processGO:0032803 regulation of low-density lipoprotein particle receptor catabolic process IMP
 biological_processGO:0032805 positive regulation of low-density lipoprotein particle receptor catabolic process ISO
 biological_processGO:0032869 cellular response to insulin stimulus ISO
 biological_processGO:0042157 lipoprotein metabolic process IDA
 biological_processGO:0042632 cholesterol homeostasis ISS
 biological_processGO:0043523 regulation of neuron apoptotic process IMP
 biological_processGO:0043525 positive regulation of neuron apoptotic process ISS
 biological_processGO:1905596 negative regulation of low-density lipoprotein particle receptor binding ISO
 biological_processGO:1905598 negative regulation of low-density lipoprotein receptor activity ISO
 biological_processGO:1905601 negative regulation of receptor-mediated endocytosis involved in cholesterol transport ISO
 biological_processGO:2000650 negative regulation of sodium ion transmembrane transporter activity ISO
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome ISO
 cellular_componentGO:0005770 late endosome ISO
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005791 rough endoplasmic reticulum ISO
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0030134 COPII-coated ER to Golgi transport vesicle IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 cellular_componentGO:1990666 PCSK9-LDLR complex ISO
 cellular_componentGO:1990667 PCSK9-AnxA2 complex ISO
 molecular_functionGO:0004252 serine-type endopeptidase activity ISS
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019871 sodium channel inhibitor activity ISO
 molecular_functionGO:0030169 low-density lipoprotein particle binding IDA
 molecular_functionGO:0030547 receptor inhibitor activity ISO
 molecular_functionGO:0034185 apolipoprotein binding IDA
 molecular_functionGO:0034189 very-low-density lipoprotein particle binding IDA
 molecular_functionGO:0034190 apolipoprotein receptor binding ISO
 molecular_functionGO:0043621 protein self-association ISO
 molecular_functionGO:0050750 low-density lipoprotein particle receptor binding ISO
 molecular_functionGO:0070326 very-low-density lipoprotein particle receptor binding ISO


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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