1026


Homo sapiens (NCBI)

Features
Gene ID: 1026
  
Biological name :
  
Synonyms : CAP20|CDKN1|CIP1|MDA-6|P21|SDI1|WAF1|p21CIP1 / CDKN1A / cyclin dependent kinase inhibitor 1A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 202284_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 11386203
RefSeq - 17978495
RefSeq - 334085240
RefSeq - 334085242
RefSeq - 614458211
RefSeq - NC_000006.12
RefSeq - NG_009364.1
RefSeq - NP_000380.1
RefSeq - NP_001207706.1
RefSeq - NP_001207707.1
RefSeq - NP_001278478.1
RefSeq - NP_510867.1
RefSeq - NM_000389.4
RefSeq - NM_001220777.1
RefSeq - NM_001220778.1
RefSeq - NM_001291549.1
RefSeq - NM_078467.2
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000124762 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS
 biological_processGO:0000082 G1/S transition of mitotic cell cycle TAS
 biological_processGO:0000086 G2/M transition of mitotic cell cycle IMP
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
 biological_processGO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IEA
 biological_processGO:0007050 cell cycle arrest IMP
 biological_processGO:0007265 Ras protein signal transduction IEP
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010165 response to X-ray IEA
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030308 negative regulation of cell growth IDA
 biological_processGO:0030890 positive regulation of B cell proliferation IEA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0031668 cellular response to extracellular stimulus IMP
 biological_processGO:0033158 regulation of protein import into nucleus, translocation IEA
 biological_processGO:0034198 cellular response to amino acid starvation IMP
 biological_processGO:0034605 cellular response to heat IEA
 biological_processGO:0042326 negative regulation of phosphorylation IDA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043068 positive regulation of programmed cell death IEA
 biological_processGO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IDA
 biological_processGO:0046685 response to arsenic-containing substance IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IMP
 biological_processGO:0050821 protein stabilization TAS
 biological_processGO:0051412 response to corticosterone IEA
 biological_processGO:0055093 response to hyperoxia IEA
 biological_processGO:0060574 intestinal epithelial cell maturation IEA
 biological_processGO:0071479 cellular response to ionizing radiation IMP
 biological_processGO:0071480 cellular response to gamma radiation IEA
 biological_processGO:0071493 cellular response to UV-B ISS
 biological_processGO:0071850 mitotic cell cycle arrest IEA
 biological_processGO:0090398 cellular senescence IMP
 biological_processGO:0090399 replicative senescence IEA
 biological_processGO:0090400 stress-induced premature senescence TAS
 biological_processGO:0097193 intrinsic apoptotic signaling pathway TAS
 biological_processGO:1904030 negative regulation of cyclin-dependent protein kinase activity IMP
 biological_processGO:1904031 positive regulation of cyclin-dependent protein kinase activity IEA
 biological_processGO:1904706 negative regulation of vascular smooth muscle cell proliferation IMP
 biological_processGO:2000134 negative regulation of G1/S transition of mitotic cell cycle IGI
 biological_processGO:2000278 regulation of DNA biosynthetic process IEA
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IMP
 cellular_componentGO:0000307 cyclin-dependent protein kinase holoenzyme complex IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070557 PCNA-p21 complex IDA
 molecular_functionGO:0004693 cyclin-dependent protein serine/threonine kinase activity EXP
 molecular_functionGO:0004860 protein kinase inhibitor activity IMP
 molecular_functionGO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0019912 cyclin-dependent protein kinase activating kinase activity IDA
 molecular_functionGO:0030332 cyclin binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0044877 protein-containing complex binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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