14257


Mus musculus (NCBI)
regulationproteinkinaseactivityendothelialreceptorgrowthbindingcellsignalingvascularfactorphosphorylationdevelopmentmembranevesseltransmembranetyrosinepathwaycascadeangiogenesisproliferationrespiratoryprocessblooderkplasmaintegralcomponentvasculogenesis

Features
Gene ID: 14257
  
Biological name :
  
Synonyms : AI323512|Chy|Flt-4|VEGFR-3|VEGFR3 / Flt4 / FMS-like tyrosine kinase 4
  
Possible biological names infered from orthology :
  
Species: Mus musculus (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1421442_at (Mouse Genome 430 2.0 Array)   1444052_at (Mouse Genome 430 2.0 Array)   
  
Cross references: RefSeq - 6679813
RefSeq - NC_000077.6
RefSeq - NP_032055.1
RefSeq - NM_008029.3
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSMUSG00000020357 to get all the annotations available for this gene.


Gene Ontology (GO)
anatomical structure developmentcellular developmental processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processepithelial cell proliferationsystem processrespiratory gaseous exchangecell communicationcellular response to stimuluscytokine productionlocalization of cellmovement of cell or subcellular componenttissue migrationcellular component organizationcell growthregulation of molecular functionresponse to chemicalcell deathresponse to stresstissue remodelinganatomical structure developmentcellular developmental processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processepithelial cell proliferationsystem processrespiratory gaseous exchangecell communicationcellular response to stimuluscytokine productionlocalization of cellmovement of cell or subcellular componenttissue migrationcellular component organizationcell growthregulation of molecular functionresponse to chemicalcell deathresponse to stresstissue remodelinganatomical structure developmentcellular developmental processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processepithelial cell proliferationsystem processrespiratory gaseous exchangecell communicationcellular response to stimuluscytokine productionlocalization of cellmovement of cell or subcellular componenttissue migrationcellular component organizationcell growthregulation of molecular functionresponse to chemicalcell deathresponse to stresstissue remodelinganatomical structure developmentcellular developmental processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processepithelial cell proliferationsystem processrespiratory gaseous exchangecell communicationcellular response to stimuluscytokine productionlocalization of cellmovement of cell or subcellular componenttissue migrationcellular component organizationcell growthregulation of molecular functionresponse to chemicalcell deathresponse to stresstissue remodelinganatomical structure developmentcellular developmental processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processepithelial cell proliferationsystem processrespiratory gaseous exchangecell communicationcellular response to stimuluscytokine productionlocalization of cellmovement of cell or subcellular componenttissue migrationcellular component organizationcell growthregulation of molecular functionresponse to chemicalcell deathresponse to stresstissue remodelinganatomical structure developmentcellular developmental processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processepithelial cell proliferationsystem processrespiratory gaseous exchangecell communicationcellular response to stimuluscytokine productionlocalization of cellmovement of cell or subcellular componenttissue migrationcellular component organizationcell growthregulation of molecular functionresponse to chemicalcell deathresponse to stresstissue remodelinganatomical structure developmentcellular developmental processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processepithelial cell proliferationsystem processrespiratory gaseous exchangecell communicationcellular response to stimuluscytokine productionlocalization of cellmovement of cell or subcellular componenttissue migrationcellular component organizationcell growthregulation of molecular functionresponse to chemicalcell deathresponse to stresstissue remodelinganatomical structure developmentcellular developmental processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processepithelial cell proliferationsystem processrespiratory gaseous exchangecell communicationcellular response to stimuluscytokine productionlocalization of cellmovement of cell or subcellular componenttissue migrationcellular component organizationcell growthregulation of molecular functionresponse to chemicalcell deathresponse to stresstissue remodelinganatomical structure developmentcellular developmental processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processepithelial cell proliferationsystem processrespiratory gaseous exchangecell communicationcellular response to stimuluscytokine productionlocalization of cellmovement of cell or subcellular componenttissue migrationcellular component organizationcell growthregulation of molecular functionresponse to chemicalcell deathresponse to stresstissue remodelinganatomical structure developmentcellular developmental processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processepithelial cell proliferationsystem processrespiratory gaseous exchangecell communicationcellular response to stimuluscytokine productionlocalization of cellmovement of cell or subcellular componenttissue migrationcellular component organizationcell growthregulation of molecular functionresponse to chemicalcell deathresponse to stresstissue remodelinganatomanatomical structure developmentcellulcellular developmental processnitrognitrogen compound metabolic processcellulcellular metabolic processprimarprimary metabolic processorganiorganic substance metabolic processepitheepithelial cell proliferationsystemsystem processrespirrespiratory gaseous exchangecell ccell communicationcellulcellular response to stimuluscytokicytokine productionlocalilocalization of cellmovememovement of cell or subcellular componenttissuetissue migrationcellulcellular component organizationcell gcell growthregularegulation of molecular functionresponresponse to chemicalcell dcell deathresponresponse to stresstissuetissue remodeling
organic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingorganic cyclicorganic cyclic compound bindingheterocyclic cheterocyclic compound bindingsmall moleculesmall molecule bindingcatalytic acticatalytic activity, acting on a proteintransferase actransferase activitysignaling recesignaling receptor activityprotein bindinprotein bindingion bindingion bindingcarbohydrate dcarbohydrate derivative bindingdrug bindingdrug binding
cellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenmembranemembraneprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001570 vasculogenesis IBA
 biological_processGO:0001934 positive regulation of protein phosphorylation ISO
 biological_processGO:0001938 positive regulation of endothelial cell proliferation ISO
 biological_processGO:0001944 vasculature development IMP
 biological_processGO:0001945 lymph vessel development IMP
 biological_processGO:0001946 lymphangiogenesis ISO
 biological_processGO:0002040 sprouting angiogenesis IMP
 biological_processGO:0003016 respiratory system process IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0007585 respiratory gaseous exchange IMP
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0009968 negative regulation of signal transduction IBA
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production ISO
 biological_processGO:0010595 positive regulation of endothelial cell migration ISO
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation ISO
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0030307 positive regulation of cell growth ISO
 biological_processGO:0033674 positive regulation of kinase activity IBA
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus ISO
 biological_processGO:0038084 vascular endothelial growth factor signaling pathway ISO
 biological_processGO:0043066 negative regulation of apoptotic process ISO
 biological_processGO:0043410 positive regulation of MAPK cascade ISO
 biological_processGO:0046330 positive regulation of JNK cascade ISO
 biological_processGO:0046777 protein autophosphorylation ISO
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway ISO
 biological_processGO:0048286 lung alveolus development IMP
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0060312 regulation of blood vessel remodeling IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISO
 biological_processGO:0090037 positive regulation of protein kinase C signaling ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IBA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity ISO
 molecular_functionGO:0004888 transmembrane signaling receptor activity IBA
 molecular_functionGO:0005021 vascular endothelial growth factor-activated receptor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019838 growth factor binding ISO
 molecular_functionGO:0019903 protein phosphatase binding ISO
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IBA
 molecular_functionGO:0036328 VEGF-C-activated receptor activity ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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