15357


Mus musculus (NCBI)
processregulationmetabolicactivitybiosyntheticcellmusclemembranebindingapoptoticproteinlipidsteroidcholesterolproliferationcoenzymecascadecellularerkendoplasmicreticulumhydroxymethylglutaryl-coareductasenadphoxidoreductasenadpubiquinoneisoprenoidvisuallearning

Features
Gene ID: 15357
  
Biological name :
  
Synonyms : 3-hydroxy-3-methylglutaryl-Coenzyme A reductase / HMG-CoAR|Red / Hmgcr
  
Possible biological names infered from orthology :
  
Species: Mus musculus (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1427229_at (Mouse Genome 430 2.0 Array)   1451766_at (Mouse Genome 430 2.0 Array)   
  
Cross references: RefSeq - 1335348621
RefSeq - 1335348689
RefSeq - 160358778
RefSeq - 568984222
RefSeq - 568984224
RefSeq - NC_000079.6
RefSeq - NP_001347094.1
RefSeq - NP_001347095.1
RefSeq - NP_032281.2
RefSeq - XP_006517593.1
RefSeq - XP_006517594.1
RefSeq - NM_001360165.1
RefSeq - NM_001360166.1
RefSeq - NM_008255.2
RefSeq - XM_006517531.1
RefSeq - XM_006517530.1
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSMUSG00000021670 to get all the annotations available for this gene.


Gene Ontology (GO)
primary metabolic processorganic substance metabolic processbiosynthetic processsmall molecule metabolic processcellular metabolic processsystem processresponse to abiotic stimuluscell deathnitrogen compound metabolic processresponse to stresscell communicationcellular response to stimulusregulation of molecular functionanatomical structure developmentmuscle cell proliferationcellular component organizationcellular component biogenesisoxidation-reduction processresponse to external stimulusmacromolecule localizationresponse to chemicalestablishment of localizationregulation of biological qualitycellular localizationprimary metabolic processorganic substance metabolic processbiosynthetic processsmall molecule metabolic processcellular metabolic processsystem processresponse to abiotic stimuluscell deathnitrogen compound metabolic processresponse to stresscell communicationcellular response to stimulusregulation of molecular functionanatomical structure developmentmuscle cell proliferationcellular component organizationcellular component biogenesisoxidation-reduction processresponse to external stimulusmacromolecule localizationresponse to chemicalestablishment of localizationregulation of biological qualitycellular localizationprimary metabolic processorganic substance metabolic processbiosynthetic processsmall molecule metabolic processcellular metabolic processsystem processresponse to abiotic stimuluscell deathnitrogen compound metabolic processresponse to stresscell communicationcellular response to stimulusregulation of molecular functionanatomical structure developmentmuscle cell proliferationcellular component organizationcellular component biogenesisoxidation-reduction processresponse to external stimulusmacromolecule localizationresponse to chemicalestablishment of localizationregulation of biological qualitycellular localizationprimary metabolic processorganic substance metabolic processbiosynthetic processsmall molecule metabolic processcellular metabolic processsystem processresponse to abiotic stimuluscell deathnitrogen compound metabolic processresponse to stresscell communicationcellular response to stimulusregulation of molecular functionanatomical structure developmentmuscle cell proliferationcellular component organizationcellular component biogenesisoxidation-reduction processresponse to external stimulusmacromolecule localizationresponse to chemicalestablishment of localizationregulation of biological qualitycellular localizationprimary metabolic processorganic substance metabolic processbiosynthetic processsmall molecule metabolic processcellular metabolic processsystem processresponse to abiotic stimuluscell deathnitrogen compound metabolic processresponse to stresscell communicationcellular response to stimulusregulation of molecular functionanatomical structure developmentmuscle cell proliferationcellular component organizationcellular component biogenesisoxidation-reduction processresponse to external stimulusmacromolecule localizationresponse to chemicalestablishment of localizationregulation of biological qualitycellular localizationprimary metabolic processorganic substance metabolic processbiosynthetic processsmall molecule metabolic processcellular metabolic processsystem processresponse to abiotic stimuluscell deathnitrogen compound metabolic processresponse to stresscell communicationcellular response to stimulusregulation of molecular functionanatomical structure developmentmuscle cell proliferationcellular component organizationcellular component biogenesisoxidation-reduction processresponse to external stimulusmacromolecule localizationresponse to chemicalestablishment of localizationregulation of biological qualitycellular localizationprimary metabolic processorganic substance metabolic processbiosynthetic processsmall molecule metabolic processcellular metabolic processsystem processresponse to abiotic stimuluscell deathnitrogen compound metabolic processresponse to stresscell communicationcellular response to stimulusregulation of molecular functionanatomical structure developmentmuscle cell proliferationcellular component organizationcellular component biogenesisoxidation-reduction processresponse to external stimulusmacromolecule localizationresponse to chemicalestablishment of localizationregulation of biological qualitycellular localizationprimary metabolic processorganic substance metabolic processbiosynthetic processsmall molecule metabolic processcellular metabolic processsystem processresponse to abiotic stimuluscell deathnitrogen compound metabolic processresponse to stresscell communicationcellular response to stimulusregulation of molecular functionanatomical structure developmentmuscle cell proliferationcellular component organizationcellular component biogenesisoxidation-reduction processresponse to external stimulusmacromolecule localizationresponse to chemicalestablishment of localizationregulation of biological qualitycellular localizationprimary metabolic processorganic substance metabolic processbiosynthetic processsmall molecule metabolic processcellular metabolic processsystem processresponse to abiotic stimuluscell deathnitrogen compound metabolic processresponse to stresscell communicationcellular response to stimulusregulation of molecular functionanatomical structure developmentmuscle cell proliferationcellular component organizationcellular component biogenesisoxidation-reduction processresponse to external stimulusmacromolecule localizationresponse to chemicalestablishment of localizationregulation of biological qualitycellular localizationprimary metabolic processorganic substance metabolic processbiosynthetic processsmall molecule metabolic processcellular metabolic processsystem processresponse to abiotic stimuluscell deathnitrogen compound metabolic processresponse to stresscell communicationcellular response to stimulusregulation of molecular functionanatomical structure developmentmuscle cell proliferationcellular component organizationcellular component biogenesisoxidation-reduction processresponse to external stimulusmacromolecule localizationresponse to chemicalestablishment of localizationregulation of biological qualitycellular localizationprimaprimary metabolic processorganorganic substance metabolic processbiosybiosynthetic processsmallsmall molecule metabolic processcellucellular metabolic processsystesystem processresporesponse to abiotic stimuluscell cell deathnitronitrogen compound metabolic processresporesponse to stresscell cell communicationcellucellular response to stimulusregulregulation of molecular functionanatoanatomical structure developmentmusclmuscle cell proliferationcellucellular component organizationcellucellular component biogenesisoxidaoxidation-reduction processresporesponse to external stimulusmacromacromolecule localizationresporesponse to chemicalestabestablishment of localizationregulregulation of biological qualitycellucellular localization
oxidoreductase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingion bindingoxidoreductase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingion bindingoxidoreductase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingion bindingoxidoreductase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingion bindingoxidoreductase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingion bindingoxidoreductase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingion bindingoxidoreductase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingion bindingoxidoreductase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingion bindingoxidoreductase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingion bindingoxidoreductase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingion bindingoxidoreductase activoxidoreductase activityprotein bindingprotein bindingorganic cyclic compoorganic cyclic compound bindingheterocyclic compounheterocyclic compound bindingcofactor bindingcofactor bindingsmall molecule bindismall molecule bindingion bindingion binding
cellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellcellmembranemembraneorganelleorganelle
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0006695 cholesterol biosynthetic process ISO
 biological_processGO:0006743 ubiquinone metabolic process ISO
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0008299 isoprenoid biosynthetic process ISO
 biological_processGO:0008542 visual learning IGI
 biological_processGO:0010664 negative regulation of striated muscle cell apoptotic process ISO
 biological_processGO:0010666 positive regulation of cardiac muscle cell apoptotic process ISO
 biological_processGO:0015936 coenzyme A metabolic process IEA
 biological_processGO:0016126 sterol biosynthetic process IEA
 biological_processGO:0032874 positive regulation of stress-activated MAPK cascade ISO
 biological_processGO:0043066 negative regulation of apoptotic process ISO
 biological_processGO:0043407 negative regulation of MAP kinase activity IGI
 biological_processGO:0044255 cellular lipid metabolic process IBA
 biological_processGO:0048643 positive regulation of skeletal muscle tissue development ISO
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation ISO
 biological_processGO:0051262 protein tetramerization ISO
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0061045 negative regulation of wound healing ISO
 biological_processGO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus ISO
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISO
 biological_processGO:0097756 negative regulation of blood vessel diameter ISO
 cellular_componentGO:0005778 peroxisomal membrane ISO
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0042282 hydroxymethylglutaryl-CoA reductase activity ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0050661 NADP binding IEA
 molecular_functionGO:0050662 coenzyme binding ISO
 molecular_functionGO:0051721 protein phosphatase 2A binding ISO
 molecular_functionGO:0070402 NADPH binding ISO


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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