1956


Homo sapiens (NCBI)

Features
Gene ID: 1956
  
Biological name :
  
Synonyms : EGFR / epidermal growth factor receptor / ERBB|ERBB1|HER1|NISBD2|PIG61|mENA
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1565483_at (Human Genome U133 Plus 2.0 Array)   1565484_x_at (Human Genome U133 Plus 2.0 Array)   201983_s_at (Human Genome U133 Plus 2.0 Array)   201984_s_at (Human Genome U133 Plus 2.0 Array)   210984_x_at (Human Genome U133 Plus 2.0 Array)   211550_at (Human Genome U133 Plus 2.0 Array)   211551_at (Human Genome U133 Plus 2.0 Array)   211607_x_at (Human Genome U133 Plus 2.0 Array)   224999_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 1100818972
RefSeq - 1100818974
RefSeq - 1100818978
RefSeq - 1100832916
RefSeq - 1101020101
RefSeq - 29725609
RefSeq - 41327732
RefSeq - 41327734
RefSeq - 41327736
RefSeq - NC_000007.14
RefSeq - NG_007726.3
RefSeq - NP_001333826.1
RefSeq - NP_001333827.1
RefSeq - NP_001333828.1
RefSeq - NP_001333829.1
RefSeq - NP_001333870.1
RefSeq - NP_005219.2
RefSeq - NP_958439.1
RefSeq - NP_958440.1
RefSeq - NP_958441.1
RefSeq - NM_001346897.1
RefSeq - NM_001346898.1
RefSeq - NM_001346899.1
RefSeq - NM_001346900.1
RefSeq - NM_001346941.1
RefSeq - NM_005228.4
RefSeq - NM_201282.1
RefSeq - NM_201283.1
RefSeq - NM_201284.1
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000146648 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0001503 ossification NAS
 biological_processGO:0001892 embryonic placenta development IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0001942 hair follicle development IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006412 translation IEA
 biological_processGO:0006970 response to osmotic stress IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007166 cell surface receptor signaling pathway IDA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway TAS
 biological_processGO:0007202 activation of phospholipase C activity TAS
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0007435 salivary gland morphogenesis IEA
 biological_processGO:0007494 midgut development IEA
 biological_processGO:0007611 learning or memory ISS
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0008283 cell proliferation IDA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0009968 negative regulation of signal transduction IBA
 biological_processGO:0010750 positive regulation of nitric oxide mediated signal transduction IDA
 biological_processGO:0010960 magnesium ion homeostasis IEA
 biological_processGO:0014066 regulation of phosphatidylinositol 3-kinase signaling IMP
 biological_processGO:0016101 diterpenoid metabolic process IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0021795 cerebral cortex cell migration IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0030307 positive regulation of cell growth IDA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0031659 positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle IDA
 biological_processGO:0032930 positive regulation of superoxide anion generation IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IMP
 biological_processGO:0033590 response to cobalamin IEA
 biological_processGO:0033594 response to hydroxyisoflavone IEA
 biological_processGO:0033674 positive regulation of kinase activity IBA
 biological_processGO:0034614 cellular response to reactive oxygen species IMP
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation TAS
 biological_processGO:0038128 ERBB2 signaling pathway TAS
 biological_processGO:0042059 negative regulation of epidermal growth factor receptor signaling pathway TAS
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042177 negative regulation of protein catabolic process IDA
 biological_processGO:0042327 positive regulation of phosphorylation IDA
 biological_processGO:0042698 ovulation cycle IEA
 biological_processGO:0042743 hydrogen peroxide metabolic process IEA
 biological_processGO:0043006 activation of phospholipase A2 activity by calcium-mediated signaling TAS
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043406 positive regulation of MAP kinase activity IDA
 biological_processGO:0043410 positive regulation of MAPK cascade IBA
 biological_processGO:0043586 tongue development IEA
 biological_processGO:0045739 positive regulation of DNA repair IDA
 biological_processGO:0045740 positive regulation of DNA replication IDA
 biological_processGO:0045746 negative regulation of Notch signaling pathway TAS
 biological_processGO:0045780 positive regulation of bone resorption IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045907 positive regulation of vasoconstriction IEA
 biological_processGO:0045930 negative regulation of mitotic cell cycle IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046328 regulation of JNK cascade IMP
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0046777 protein autophosphorylation IMP
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0048143 astrocyte activation IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0048546 digestive tract morphogenesis IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0048812 neuron projection morphogenesis IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IDA
 biological_processGO:0050729 positive regulation of inflammatory response IEA
 biological_processGO:0050730 regulation of peptidyl-tyrosine phosphorylation IMP
 biological_processGO:0050999 regulation of nitric-oxide synthase activity IDA
 biological_processGO:0051205 protein insertion into membrane TAS
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling TAS
 biological_processGO:0051968 positive regulation of synaptic transmission, glutamatergic IEA
 biological_processGO:0060571 morphogenesis of an epithelial fold IEA
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0061029 eyelid development in camera-type eye IEA
 biological_processGO:0070141 response to UV-A IDA
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0071230 cellular response to amino acid stimulus IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071276 cellular response to cadmium ion IMP
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus ISS
 biological_processGO:0071392 cellular response to estradiol stimulus IDA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IMP
 biological_processGO:0097421 liver regeneration IEA
 biological_processGO:0097755 positive regulation of blood vessel diameter IEA
 biological_processGO:0098609 cell-cell adhesion IMP
 biological_processGO:1900020 positive regulation of protein kinase C activity IDA
 biological_processGO:1901185 negative regulation of ERBB signaling pathway TAS
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IMP
 biological_processGO:1902722 positive regulation of prolactin secretion IEA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IDA
 biological_processGO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA IMP
 biological_processGO:1905208 negative regulation of cardiocyte differentiation IMP
 biological_processGO:2000145 regulation of cell motility TAS
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005615 extracellular space NAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005768 endosome IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0009925 basal plasma membrane IBA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0010008 endosome membrane IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030122 AP-2 adaptor complex TAS
 cellular_componentGO:0030665 clathrin-coated vesicle membrane TAS
 cellular_componentGO:0031901 early endosome membrane IDA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0043235 receptor complex IDA
 cellular_componentGO:0045121 membrane raft IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070435 Shc-EGFR complex ISS
 cellular_componentGO:0097489 multivesicular body, internal vesicle lumen IDA
 molecular_functionGO:0001618 virus receptor activity IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003690 double-stranded DNA binding NAS
 molecular_functionGO:0004709 MAP kinase kinase kinase activity NAS
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity TAS
 molecular_functionGO:0004888 transmembrane signaling receptor activity IDA
 molecular_functionGO:0005006 epidermal growth factor-activated receptor activity NAS
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IPI
 molecular_functionGO:0030235 nitric-oxide synthase regulator activity IDA
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IBA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0045296 cadherin binding HDA
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS
 molecular_functionGO:0046982 protein heterodimerization activity IDA
 molecular_functionGO:0048408 epidermal growth factor binding IEA
 molecular_functionGO:0051015 actin filament binding IDA


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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