2022


Homo sapiens (NCBI)

Features
Gene ID: 2022
  
Biological name :
  
Synonyms : END|HHT1|ORW1 / endoglin / ENG
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 201808_s_at (Human Genome U133 Plus 2.0 Array)   201809_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 168693647
RefSeq - 4557555
RefSeq - 497240517
RefSeq - NC_000009.12
RefSeq - NG_009551.1
RefSeq - NP_000109.1
RefSeq - NP_001108225.1
RefSeq - NP_001265067.1
RefSeq - NM_000118.3
RefSeq - NM_001114753.2
RefSeq - NM_001278138.1
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000106991 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001300 chronological cell aging IEA
 biological_processGO:0001569 branching involved in blood vessel morphogenesis ISS
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0001947 heart looping ISS
 biological_processGO:0002040 sprouting angiogenesis ISS
 biological_processGO:0003148 outflow tract septum morphogenesis ISS
 biological_processGO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation ISS
 biological_processGO:0003203 endocardial cushion morphogenesis ISS
 biological_processGO:0003208 cardiac ventricle morphogenesis ISS
 biological_processGO:0003209 cardiac atrium morphogenesis ISS
 biological_processGO:0003222 ventricular trabecula myocardium morphogenesis ISS
 biological_processGO:0003273 cell migration involved in endocardial cushion formation IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0010629 negative regulation of gene expression ISS
 biological_processGO:0010665 regulation of cardiac muscle cell apoptotic process ISS
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IDA
 biological_processGO:0017015 regulation of transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0022009 central nervous system vasculogenesis IMP
 biological_processGO:0030336 negative regulation of cell migration IDA
 biological_processGO:0030509 BMP signaling pathway TAS
 biological_processGO:0030513 positive regulation of BMP signaling pathway IDA
 biological_processGO:0031953 negative regulation of protein autophosphorylation IDA
 biological_processGO:0031960 response to corticosteroid IEA
 biological_processGO:0032967 positive regulation of collagen biosynthetic process IEA
 biological_processGO:0035912 dorsal aorta morphogenesis ISS
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0048745 smooth muscle tissue development ISS
 biological_processGO:0048844 artery morphogenesis ISS
 biological_processGO:0048845 venous blood vessel morphogenesis ISS
 biological_processGO:0051897 positive regulation of protein kinase B signaling IGI
 biological_processGO:0055009 atrial cardiac muscle tissue morphogenesis ISS
 biological_processGO:0060348 bone development IEA
 biological_processGO:0070278 extracellular matrix constituent secretion IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071559 response to transforming growth factor beta IEA
 biological_processGO:0090500 endocardial cushion to mesenchymal transition ISS
 biological_processGO:0097084 vascular smooth muscle cell development ISS
 biological_processGO:1905007 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation ISS
 biological_processGO:1905065 positive regulation of vascular smooth muscle cell differentiation ISS
 biological_processGO:1905222 atrioventricular canal morphogenesis ISS
 biological_processGO:1905310 regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis ISS
 biological_processGO:2000136 regulation of cell proliferation involved in heart morphogenesis ISS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0043235 receptor complex IPI
 cellular_componentGO:0070022 transforming growth factor beta receptor complex IC
 cellular_componentGO:0072563 endothelial microparticle IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity NAS
 molecular_functionGO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity IDA
 molecular_functionGO:0005114 type II transforming growth factor beta receptor binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005534 galactose binding IDA
 molecular_functionGO:0005539 glycosaminoglycan binding ISS
 molecular_functionGO:0034713 type I transforming growth factor beta receptor binding ISS
 molecular_functionGO:0036122 BMP binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0048185 activin binding TAS
 molecular_functionGO:0050431 transforming growth factor beta binding IPI


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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