2064


Homo sapiens (NCBI)

Features
Gene ID: 2064
  
Biological name :
  
Synonyms : CD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1 / ERBB2 / erb-b2 receptor tyrosine kinase 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 210930_s_at (Human Genome U133 Plus 2.0 Array)   216836_s_at (Human Genome U133 Plus 2.0 Array)   234354_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 1370470416
RefSeq - 1370470418
RefSeq - 1370470420
RefSeq - 54792096
RefSeq - 54792098
RefSeq - 584277103
RefSeq - 584277106
RefSeq - 584277109
RefSeq - NC_000017.11
RefSeq - NG_007503.1
RefSeq - NP_001005862.1
RefSeq - NP_001276865.1
RefSeq - NP_001276866.1
RefSeq - NP_001276867.1
RefSeq - NP_004439.2
RefSeq - XP_024306409.1
RefSeq - XP_024306410.1
RefSeq - XP_024306411.1
RefSeq - XM_024450642.1
RefSeq - NM_001005862.2
RefSeq - NM_001289936.1
RefSeq - NM_001289937.1
RefSeq - NM_001289938.1
RefSeq - NM_004448.3
RefSeq - XM_024450643.1
RefSeq - NR_110535.1
RefSeq - XM_024450641.1
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000141736 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0001934 positive regulation of protein phosphorylation ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006468 protein phosphorylation TAS
 biological_processGO:0007165 signal transduction IDA
 biological_processGO:0007166 cell surface receptor signaling pathway IDA
 biological_processGO:0007167 enzyme linked receptor protein signaling pathway TAS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0007422 peripheral nervous system development IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007528 neuromuscular junction development IEA
 biological_processGO:0008045 motor neuron axon guidance IEA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0009968 negative regulation of signal transduction IBA
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IDA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0030307 positive regulation of cell growth IMP
 biological_processGO:0032886 regulation of microtubule-based process IDA
 biological_processGO:0033088 negative regulation of immature T cell proliferation in thymus IEA
 biological_processGO:0033674 positive regulation of kinase activity IBA
 biological_processGO:0038128 ERBB2 signaling pathway TAS
 biological_processGO:0042060 wound healing IDA
 biological_processGO:0042552 myelination IEA
 biological_processGO:0043066 negative regulation of apoptotic process IBA
 biological_processGO:0043406 positive regulation of MAP kinase activity IDA
 biological_processGO:0043410 positive regulation of MAPK cascade IBA
 biological_processGO:0043547 positive regulation of GTPase activity ISS
 biological_processGO:0045727 positive regulation of translation IMP
 biological_processGO:0045765 regulation of angiogenesis NAS
 biological_processGO:0045785 positive regulation of cell adhesion IDA
 biological_processGO:0045943 positive regulation of transcription by RNA polymerase I IMP
 biological_processGO:0045945 positive regulation of transcription by RNA polymerase III IDA
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0048709 oligodendrocyte differentiation IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IDA
 biological_processGO:0051897 positive regulation of protein kinase B signaling TAS
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 biological_processGO:0071363 cellular response to growth factor stimulus IDA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IMP
 biological_processGO:0090314 positive regulation of protein targeting to membrane IDA
 biological_processGO:1901185 negative regulation of ERBB signaling pathway TAS
 biological_processGO:2000145 regulation of cell motility TAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0009925 basal plasma membrane IBA
 cellular_componentGO:0010008 endosome membrane IDA
 cellular_componentGO:0016021 integral component of membrane NAS
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0043235 receptor complex TAS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0001042 RNA polymerase I core binding IDA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IBA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IDA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IDA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0019838 growth factor binding IDA
 molecular_functionGO:0019903 protein phosphatase binding IPI
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IBA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0043125 ErbB-3 class receptor binding TAS
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0046983 protein dimerization activity NAS


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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