2065


Homo sapiens (NCBI)

Features
Gene ID: 2065
  
Biological name :
  
Synonyms : erb-b2 receptor tyrosine kinase 3 / ERBB3 / ErbB-3|HER3|LCCS2|MDA-BF-1|c-erbB-3|c-erbB3|erbB3-S|p180-ErbB3|p45-sErbB3|p85-sErbB3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1563252_at (Human Genome U133 Plus 2.0 Array)   1563253_s_at (Human Genome U133 Plus 2.0 Array)   202454_s_at (Human Genome U133 Plus 2.0 Array)   215638_at (Human Genome U133 Plus 2.0 Array)   226213_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 54792100
RefSeq - 54792102
RefSeq - NC_000012.12
RefSeq - NG_011529.1
RefSeq - NP_001005915.1
RefSeq - NP_001973.2
RefSeq - NM_001005915.1
RefSeq - NM_001982.3
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000065361 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0003197 endocardial cushion development IEA
 biological_processGO:0007162 negative regulation of cell adhesion IDA
 biological_processGO:0007165 signal transduction IDA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway ISS
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0007422 peripheral nervous system development ISS
 biological_processGO:0007507 heart development ISS
 biological_processGO:0009968 negative regulation of signal transduction IDA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0014037 Schwann cell differentiation ISS
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IDA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling TAS
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0021545 cranial nerve development ISS
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0033674 positive regulation of kinase activity IBA
 biological_processGO:0038128 ERBB2 signaling pathway TAS
 biological_processGO:0042060 wound healing NAS
 biological_processGO:0042127 regulation of cell proliferation IDA
 biological_processGO:0043066 negative regulation of apoptotic process IBA
 biological_processGO:0043410 positive regulation of MAPK cascade IBA
 biological_processGO:0043524 negative regulation of neuron apoptotic process ISS
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0051048 negative regulation of secretion IDA
 biological_processGO:0051402 neuron apoptotic process IMP
 biological_processGO:0051897 positive regulation of protein kinase B signaling TAS
 biological_processGO:0055025 positive regulation of cardiac muscle tissue development IEA
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 biological_processGO:0070886 positive regulation of calcineurin-NFAT signaling cascade IEA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IMP
 biological_processGO:2000145 regulation of cell motility TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009925 basal plasma membrane IBA
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0043235 receptor complex ISS
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IBA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IBA
 molecular_functionGO:0004888 transmembrane signaling receptor activity ISS
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019838 growth factor binding ISS
 molecular_functionGO:0030296 protein tyrosine kinase activator activity IDA
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IBA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0038131 neuregulin receptor activity IBA
 molecular_functionGO:0038132 neuregulin binding IDA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity NAS
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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