207


Homo sapiens (NCBI)

Features
Gene ID: 207
  
Biological name :
  
Synonyms : AKT1 / AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA / AKT serine/threonine kinase 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 207163_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - NP_001014431.1
RefSeq - NP_001014432.1
RefSeq - NP_005154.2
RefSeq - 62241011
RefSeq - NG_012188.1
RefSeq - 62241013
RefSeq - 62241015
RefSeq - NC_000014.9
RefSeq - XR_002957536.1
RefSeq - NM_001014431.1
RefSeq - NM_001014432.1
RefSeq - NM_005163.2
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000142208 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000060 protein import into nucleus, translocation IMP
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001893 maternal placenta development IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IMP
 biological_processGO:0005978 glycogen biosynthetic process IEA
 biological_processGO:0005979 regulation of glycogen biosynthetic process IMP
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0006412 translation IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006464 cellular protein modification process TAS
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006469 negative regulation of protein kinase activity ISS
 biological_processGO:0006809 nitric oxide biosynthetic process TAS
 biological_processGO:0006924 activation-induced cell death of T cells IMP
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0006979 response to oxidative stress ISS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IDA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0007281 germ cell development IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0008286 insulin receptor signaling pathway IMP
 biological_processGO:0008637 apoptotic mitochondrial changes IEA
 biological_processGO:0008643 carbohydrate transport IEA
 biological_processGO:0009408 response to heat TAS
 biological_processGO:0010507 negative regulation of autophagy IMP
 biological_processGO:0010628 positive regulation of gene expression ISS
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010748 negative regulation of plasma membrane long-chain fatty acid transport IMP
 biological_processGO:0010763 positive regulation of fibroblast migration IEA
 biological_processGO:0010765 positive regulation of sodium ion transport IEA
 biological_processGO:0010907 positive regulation of glucose metabolic process IMP
 biological_processGO:0010918 positive regulation of mitochondrial membrane potential IMP
 biological_processGO:0010951 negative regulation of endopeptidase activity IMP
 biological_processGO:0010975 regulation of neuron projection development ISS
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IMP
 biological_processGO:0016242 negative regulation of macroautophagy NAS
 biological_processGO:0016310 phosphorylation IDA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation TAS
 biological_processGO:0018107 peptidyl-threonine phosphorylation IDA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0021510 spinal cord development IEA
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0030154 cell differentiation TAS
 biological_processGO:0030163 protein catabolic process IEA
 biological_processGO:0030212 hyaluronan metabolic process IEA
 biological_processGO:0030307 positive regulation of cell growth IDA
 biological_processGO:0030334 regulation of cell migration TAS
 biological_processGO:0031018 endocrine pancreas development TAS
 biological_processGO:0031295 T cell costimulation TAS
 biological_processGO:0031397 negative regulation of protein ubiquitination IMP
 biological_processGO:0031641 regulation of myelination IEA
 biological_processGO:0031659 positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle IDA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0031929 TOR signaling NAS
 biological_processGO:0031999 negative regulation of fatty acid beta-oxidation IMP
 biological_processGO:0032079 positive regulation of endodeoxyribonuclease activity IDA
 biological_processGO:0032091 negative regulation of protein binding IMP
 biological_processGO:0032094 response to food IEA
 biological_processGO:0032148 activation of protein kinase B activity TAS
 biological_processGO:0032270 positive regulation of cellular protein metabolic process ISS
 biological_processGO:0032287 peripheral nervous system myelin maintenance IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0032869 cellular response to insulin stimulus ISS
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IDA
 biological_processGO:0034405 response to fluid shear stress IMP
 biological_processGO:0034614 cellular response to reactive oxygen species IMP
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0035655 interleukin-18-mediated signaling pathway IDA
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IEA
 biological_processGO:0038061 NIK/NF-kappaB signaling IMP
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0042981 regulation of apoptotic process ISS
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISS
 biological_processGO:0043276 anoikis NAS
 biological_processGO:0043488 regulation of mRNA stability TAS
 biological_processGO:0043491 protein kinase B signaling TAS
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IDA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IMP
 biological_processGO:0045600 positive regulation of fat cell differentiation IMP
 biological_processGO:0045725 positive regulation of glycogen biosynthetic process NAS
 biological_processGO:0045742 positive regulation of epidermal growth factor receptor signaling pathway TAS
 biological_processGO:0045792 negative regulation of cell size IEA
 biological_processGO:0045861 negative regulation of proteolysis IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045907 positive regulation of vasoconstriction IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046326 positive regulation of glucose import IMP
 biological_processGO:0046329 negative regulation of JNK cascade IEA
 biological_processGO:0046622 positive regulation of organ growth IEA
 biological_processGO:0046777 protein autophosphorylation TAS
 biological_processGO:0046889 positive regulation of lipid biosynthetic process IMP
 biological_processGO:0048009 insulin-like growth factor receptor signaling pathway IMP
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IDA
 biological_processGO:0050999 regulation of nitric-oxide synthase activity TAS
 biological_processGO:0051000 positive regulation of nitric-oxide synthase activity IMP
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0051146 striated muscle cell differentiation IEA
 biological_processGO:0051186 cofactor metabolic process TAS
 biological_processGO:0051898 negative regulation of protein kinase B signaling TAS
 biological_processGO:0060079 excitatory postsynaptic potential NAS
 biological_processGO:0060416 response to growth hormone ISS
 biological_processGO:0060644 mammary gland epithelial cell differentiation TAS
 biological_processGO:0060709 glycogen cell differentiation involved in embryonic placenta development IEA
 biological_processGO:0060716 labyrinthine layer blood vessel development IEA
 biological_processGO:0070141 response to UV-A IDA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071276 cellular response to cadmium ion IMP
 biological_processGO:0071356 cellular response to tumor necrosis factor IMP
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IEA
 biological_processGO:0071380 cellular response to prostaglandin E stimulus IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071901 negative regulation of protein serine/threonine kinase activity TAS
 biological_processGO:0072655 establishment of protein localization to mitochondrion IMP
 biological_processGO:0072656 maintenance of protein location in mitochondrion IMP
 biological_processGO:0090201 negative regulation of release of cytochrome c from mitochondria ISS
 biological_processGO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus IEA
 biological_processGO:0097194 execution phase of apoptosis IEA
 biological_processGO:0100002 negative regulation of protein kinase activity by protein phosphorylation TAS
 biological_processGO:1900182 positive regulation of protein localization to nucleus IMP
 biological_processGO:1901215 negative regulation of neuron death NAS
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 biological_processGO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway NAS
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IMP
 biological_processGO:1903721 positive regulation of I-kappaB phosphorylation IMP
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IMP
 biological_processGO:1990418 response to insulin-like growth factor stimulus ISS
 biological_processGO:2000010 positive regulation of protein localization to cell surface IEA
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand TAS
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 cellular_componentGO:0031982 vesicle IDA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0036064 ciliary basal body IEA
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0004672 protein kinase activity TAS
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity IDA
 molecular_functionGO:0005080 protein kinase C binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA
 molecular_functionGO:0016301 kinase activity IDA
 molecular_functionGO:0019899 enzyme binding ISS
 molecular_functionGO:0030235 nitric-oxide synthase regulator activity IMP
 molecular_functionGO:0032794 GTPase activating protein binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0043325 phosphatidylinositol-3,4-bisphosphate binding IDA
 molecular_functionGO:0051721 protein phosphatase 2A binding IEA
 molecular_functionGO:0071889 14-3-3 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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