22427


Mus musculus (NCBI)

Features
Gene ID: 22427
  
Biological name :
  
Synonyms : AI846146 / Werner syndrome RecQ like helicase / Wrn
  
Possible biological names infered from orthology :
  
Species: Mus musculus (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1425074_at (Mouse Genome 430 2.0 Array)   1425982_a_at (Mouse Genome 430 2.0 Array)   1450163_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: RefSeq - XP_017168151.1
RefSeq - 170763502
RefSeq - 170763504
RefSeq - 568954036
RefSeq - 568954040
RefSeq - NC_000074.6
RefSeq - NP_001116294.1
RefSeq - NP_035851.3
RefSeq - XP_006509154.1
RefSeq - XP_006509156.1
RefSeq - 1039788543
RefSeq - NM_001122822.1
RefSeq - NM_011721.4
RefSeq - XM_006509093.3
RefSeq - XM_017312662.1
RefSeq - XM_006509091.3
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSMUSG00000031583 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000723 telomere maintenance ISO
 biological_processGO:0000724 double-strand break repair via homologous recombination IBA
 biological_processGO:0000731 DNA synthesis involved in DNA repair ISO
 biological_processGO:0001302 replicative cell aging IMP
 biological_processGO:0006139 nucleobase-containing compound metabolic process IEA
 biological_processGO:0006259 DNA metabolic process ISO
 biological_processGO:0006260 DNA replication ISO
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006284 base-excision repair ISO
 biological_processGO:0006302 double-strand break repair ISO
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0006979 response to oxidative stress ISO
 biological_processGO:0007569 cell aging ISO
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008340 determination of adult lifespan IBA
 biological_processGO:0009267 cellular response to starvation ISO
 biological_processGO:0010225 response to UV-C ISO
 biological_processGO:0010259 multicellular organism aging ISO
 biological_processGO:0031297 replication fork processing ISO
 biological_processGO:0032508 DNA duplex unwinding ISO
 biological_processGO:0040009 regulation of growth rate IMP
 biological_processGO:0042981 regulation of apoptotic process ISO
 biological_processGO:0044237 cellular metabolic process IEA
 biological_processGO:0044806 G-quadruplex DNA unwinding ISO
 biological_processGO:0051345 positive regulation of hydrolase activity ISO
 biological_processGO:0061820 telomeric D-loop disassembly ISO
 biological_processGO:0071480 cellular response to gamma radiation ISO
 biological_processGO:0098530 positive regulation of strand invasion ISO
 biological_processGO:1902570 protein localization to nucleolus ISO
 cellular_componentGO:0000781 chromosome, telomeric region ISO
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005657 replication fork IMP
 cellular_componentGO:0005662 DNA replication factor A complex IBA
 cellular_componentGO:0005694 chromosome IBA
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0016607 nuclear speck ISO
 cellular_componentGO:0032389 MutLalpha complex ISO
 cellular_componentGO:0035861 site of double-strand break IBA
 cellular_componentGO:0043005 neuron projection ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding ISO
 molecular_functionGO:0000400 four-way junction DNA binding ISO
 molecular_functionGO:0000403 Y-form DNA binding ISO
 molecular_functionGO:0000405 bubble DNA binding ISO
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003678 DNA helicase activity ISO
 molecular_functionGO:0003682 chromatin binding ISO
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004003 ATP-dependent DNA helicase activity ISO
 molecular_functionGO:0004386 helicase activity ISO
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008026 ATP-dependent helicase activity IEA
 molecular_functionGO:0008408 3"-5" exonuclease activity ISO
 molecular_functionGO:0009378 four-way junction helicase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity ISO
 molecular_functionGO:0030145 manganese ion binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0043138 3"-5" DNA helicase activity ISO
 molecular_functionGO:0043140 ATP-dependent 3"-5" DNA helicase activity IBA
 molecular_functionGO:0044877 protein-containing complex binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051880 G-quadruplex DNA binding ISO
 molecular_functionGO:0061749 forked DNA-dependent helicase activity ISO
 molecular_functionGO:0061821 telomeric D-loop binding ISO
 molecular_functionGO:0070337 3"-flap-structured DNA binding ISO
 molecular_functionGO:1905773 8-hydroxy-2"-deoxyguanosine DNA binding ISO


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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