3091


Homo sapiens (NCBI)

Features
Gene ID: 3091
  
Biological name :
  
Synonyms : HIF1A / HIF-1-alpha|HIF-1A|HIF-1alpha|HIF1|HIF1-ALPHA|MOP1|PASD8|bHLHe78 / hypoxia inducible factor 1 subunit alpha
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 200989_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 31077211
RefSeq - 340545531
RefSeq - 4504385
RefSeq - NC_000014.9
RefSeq - NG_029606.1
RefSeq - NP_001230013.1
RefSeq - NP_001521.1
RefSeq - NP_851397.1
RefSeq - NM_001243084.1
RefSeq - NM_001530.3
RefSeq - NM_181054.2
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000100644 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001666 response to hypoxia IMP
 biological_processGO:0001755 neural crest cell migration IEA
 biological_processGO:0001837 epithelial to mesenchymal transition ISS
 biological_processGO:0001892 embryonic placenta development IEA
 biological_processGO:0001922 B-1 B cell homeostasis IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IC
 biological_processGO:0001947 heart looping IEA
 biological_processGO:0002052 positive regulation of neuroblast proliferation IEA
 biological_processGO:0002248 connective tissue replacement involved in inflammatory response wound healing ISS
 biological_processGO:0003151 outflow tract morphogenesis IEA
 biological_processGO:0003208 cardiac ventricle morphogenesis IEA
 biological_processGO:0006089 lactate metabolic process IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006366 transcription by RNA polymerase II IMP
 biological_processGO:0006879 cellular iron ion homeostasis IEA
 biological_processGO:0007165 signal transduction IMP
 biological_processGO:0007595 lactation IEA
 biological_processGO:0008542 visual learning IEA
 biological_processGO:0010039 response to iron ion IEP
 biological_processGO:0010468 regulation of gene expression IDA
 biological_processGO:0010573 vascular endothelial growth factor production IDA
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0010634 positive regulation of epithelial cell migration ISS
 biological_processGO:0010870 positive regulation of receptor biosynthetic process IMP
 biological_processGO:0014850 response to muscle activity IEA
 biological_processGO:0016239 positive regulation of macroautophagy IEA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0019896 axonal transport of mitochondrion IMP
 biological_processGO:0021502 neural fold elevation formation IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0030502 negative regulation of bone mineralization IEA
 biological_processGO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway IC
 biological_processGO:0032007 negative regulation of TOR signaling IEA
 biological_processGO:0032364 oxygen homeostasis IDA
 biological_processGO:0032722 positive regulation of chemokine production TAS
 biological_processGO:0032909 regulation of transforming growth factor beta2 production IMP
 biological_processGO:0032963 collagen metabolic process ISS
 biological_processGO:0035162 embryonic hemopoiesis IEA
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
 biological_processGO:0042541 hemoglobin biosynthetic process IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0042789 mRNA transcription by RNA polymerase II IC
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IMP
 biological_processGO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress IDA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IC
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0045821 positive regulation of glycolytic process IC
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045926 negative regulation of growth IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0046716 muscle cell cellular homeostasis IEA
 biological_processGO:0046886 positive regulation of hormone biosynthetic process IDA
 biological_processGO:0048546 digestive tract morphogenesis IEA
 biological_processGO:0051000 positive regulation of nitric-oxide synthase activity TAS
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0051541 elastin metabolic process ISS
 biological_processGO:0060574 intestinal epithelial cell maturation IEA
 biological_processGO:0061030 epithelial cell differentiation involved in mammary gland alveolus development IEA
 biological_processGO:0061072 iris morphogenesis IEA
 biological_processGO:0061298 retina vasculature development in camera-type eye IEA
 biological_processGO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS
 biological_processGO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia IMP
 biological_processGO:0070101 positive regulation of chemokine-mediated signaling pathway IC
 biological_processGO:0070244 negative regulation of thymocyte apoptotic process IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEP
 biological_processGO:0071456 cellular response to hypoxia IEP
 biological_processGO:0071542 dopaminergic neuron differentiation IEA
 biological_processGO:0097411 hypoxia-inducible factor-1alpha signaling pathway IEA
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IMP
 biological_processGO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IDA
 biological_processGO:1903599 positive regulation of autophagy of mitochondrion IEA
 biological_processGO:1903715 regulation of aerobic respiration IEA
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IEA
 biological_processGO:2001054 negative regulation of mesenchymal cell apoptotic process IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IPI
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0016607 nuclear speck ISS
 cellular_componentGO:0031514 motile cilium IEA
 cellular_componentGO:0032991 protein-containing complex IMP
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IDA
 cellular_componentGO:1904115 axon cytoplasm IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001076 transcription factor activity, RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
 molecular_functionGO:0002039 p53 binding IPI
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0035035 histone acetyltransferase binding IPI
 molecular_functionGO:0035257 nuclear hormone receptor binding IPI
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity TAS
 molecular_functionGO:0051879 Hsp90 protein binding IDA
 molecular_functionGO:0070888 E-box binding IEA


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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