328


Homo sapiens (NCBI)

Features
Gene ID: 328
  
Biological name :
  
Synonyms : APE|APE1|APEN|APEX|APX|HAP1|REF1 / APEX1 / apurinic/apyrimidinic endodeoxyribonuclease 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 210027_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 18375501
RefSeq - 18375503
RefSeq - 18375505
RefSeq - 346644849
RefSeq - NC_000014.9
RefSeq - NG_008718.1
RefSeq - NP_001231178.1
RefSeq - NP_001632.2
RefSeq - NP_542379.1
RefSeq - NP_542380.1
RefSeq - NM_001244249.1
RefSeq - NM_001641.3
RefSeq - NM_080648.2
RefSeq - NM_080649.2
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000100823 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000723 telomere maintenance IDA
 biological_processGO:0006281 DNA repair IDA
 biological_processGO:0006284 base-excision repair TAS
 biological_processGO:0006286 base-excision repair, base-free sugar-phosphate removal TAS
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0014912 negative regulation of smooth muscle cell migration IEA
 biological_processGO:0042981 regulation of apoptotic process IDA
 biological_processGO:0043488 regulation of mRNA stability IMP
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0071375 cellular response to peptide hormone stimulus IEA
 biological_processGO:0080111 DNA demethylation IDA
 biological_processGO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA
 biological_processGO:0097698 telomere maintenance via base-excision repair IDA
 biological_processGO:1900087 positive regulation of G1/S transition of mitotic cell cycle IEA
 biological_processGO:1903507 negative regulation of nucleic acid-templated transcription IEA
 biological_processGO:1903508 positive regulation of nucleic acid-templated transcription IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IC
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005783 endoplasmic reticulum TAS
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005840 ribosome TAS
 cellular_componentGO:0016607 nuclear speck IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003684 damaged DNA binding IDA
 molecular_functionGO:0003691 double-stranded telomeric DNA binding IDA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0003714 transcription corepressor activity TAS
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity TAS
 molecular_functionGO:0004519 endonuclease activity IDA
 molecular_functionGO:0004520 endodeoxyribonuclease activity TAS
 molecular_functionGO:0004523 RNA-DNA hybrid ribonuclease activity TAS
 molecular_functionGO:0004528 phosphodiesterase I activity TAS
 molecular_functionGO:0004844 uracil DNA N-glycosylase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IDA
 molecular_functionGO:0008309 double-stranded DNA exodeoxyribonuclease activity IDA
 molecular_functionGO:0008311 double-stranded DNA 3"-5" exodeoxyribonuclease activity IBA
 molecular_functionGO:0008408 3"-5" exonuclease activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IDA
 molecular_functionGO:0016890 site-specific endodeoxyribonuclease activity, specific for altered base IDA
 molecular_functionGO:0031490 chromatin DNA binding IDA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0046872 metal ion binding IDA
 molecular_functionGO:0051059 NF-kappaB binding IEA
 molecular_functionGO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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