3480


Homo sapiens (NCBI)

Features
Gene ID: 3480
  
Biological name :
  
Synonyms : CD221|IGFIR|IGFR|JTK13 / IGF1R / insulin like growth factor 1 receptor
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 203627_at (Human Genome U133 Plus 2.0 Array)   203628_at (Human Genome U133 Plus 2.0 Array)   208441_at (Human Genome U133 Plus 2.0 Array)   225330_at (Human Genome U133 Plus 2.0 Array)   243358_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - XP_024305681.1
RefSeq - 1034590455
RefSeq - 1034590457
RefSeq - 1034590459
RefSeq - 1370466555
RefSeq - 4557665
RefSeq - 629266062
RefSeq - 767984003
RefSeq - 767984005
RefSeq - NC_000015.10
RefSeq - NG_009492.1
RefSeq - NP_000866.1
RefSeq - NP_001278787.1
RefSeq - XP_011519818.1
RefSeq - XP_011519819.1
RefSeq - XP_016877625.1
RefSeq - XP_016877626.1
RefSeq - XP_016877627.1
RefSeq - XP_016877628.1
RefSeq - 1034590453
RefSeq - XM_017022138.1
RefSeq - NM_000875.4
RefSeq - NM_001291858.1
RefSeq - NM_152452.1
RefSeq - XM_017022139.1
RefSeq - XM_024449913.1
RefSeq - XM_011521516.2
RefSeq - XM_011521517.2
RefSeq - XM_017022136.1
RefSeq - XM_017022137.1
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000140443 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IBA
 biological_processGO:0006955 immune response IMP
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0008286 insulin receptor signaling pathway ISS
 biological_processGO:0009968 negative regulation of signal transduction IBA
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IC
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0033674 positive regulation of kinase activity IBA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IMP
 biological_processGO:0042593 glucose homeostasis IBA
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0043243 positive regulation of protein complex disassembly ISS
 biological_processGO:0046328 regulation of JNK cascade IDA
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0048009 insulin-like growth factor receptor signaling pathway IDA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IDA
 biological_processGO:0051262 protein tetramerization IDA
 biological_processGO:0051389 inactivation of MAPKK activity IDA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 biological_processGO:0097062 dendritic spine maintenance ISS
 biological_processGO:0097242 amyloid-beta clearance IMP
 biological_processGO:1904646 cellular response to amyloid-beta IGI
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IC
 cellular_componentGO:0005899 insulin receptor complex IBA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0030424 axon IBA
 cellular_componentGO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0043235 receptor complex IDA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IBA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IBA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IBA
 molecular_functionGO:0005009 insulin-activated receptor activity IBA
 molecular_functionGO:0005010 insulin-like growth factor-activated receptor activity IDA
 molecular_functionGO:0005158 insulin receptor binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005520 insulin-like growth factor binding IDA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IBA
 molecular_functionGO:0031994 insulin-like growth factor I binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding IPI
 molecular_functionGO:0043559 insulin binding IPI
 molecular_functionGO:0043560 insulin receptor substrate binding IPI


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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