3717


Homo sapiens (NCBI)

Features
Gene ID: 3717
  
Biological name :
  
Synonyms : JAK2 / Janus kinase 2 / JTK10|THCYT3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1562031_at (Human Genome U133 Plus 2.0 Array)   205841_at (Human Genome U133 Plus 2.0 Array)   205842_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 1015809665
RefSeq - 1015809690
RefSeq - 1015809696
RefSeq - 1015809734
RefSeq - 1015809762
RefSeq - 1015809800
RefSeq - 4826776
RefSeq - NC_000009.12
RefSeq - NG_009904.1
RefSeq - NP_001309123.1
RefSeq - NP_001309124.1
RefSeq - NP_001309125.1
RefSeq - NP_001309127.1
RefSeq - NP_001309128.1
RefSeq - NP_001309133.1
RefSeq - NP_004963.1
RefSeq - NM_001322194.1
RefSeq - NM_001322195.1
RefSeq - NM_001322196.1
RefSeq - NM_001322198.1
RefSeq - NM_001322199.1
RefSeq - NM_001322204.1
RefSeq - NM_004972.3
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000096968 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0006468 protein phosphorylation TAS
 biological_processGO:0006915 apoptotic process ISS
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process ISS
 biological_processGO:0007165 signal transduction ISS
 biological_processGO:0007167 enzyme linked receptor protein signaling pathway ISS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007259 JAK-STAT cascade TAS
 biological_processGO:0007260 tyrosine phosphorylation of STAT protein ISS
 biological_processGO:0007498 mesoderm development TAS
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress IEA
 biological_processGO:0010667 negative regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0010811 positive regulation of cell-substrate adhesion IDA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling ISS
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation ISS
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0022408 negative regulation of cell-cell adhesion IEA
 biological_processGO:0030041 actin filament polymerization NAS
 biological_processGO:0030154 cell differentiation ISS
 biological_processGO:0030155 regulation of cell adhesion IBA
 biological_processGO:0030218 erythrocyte differentiation ISS
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031103 axon regeneration IEA
 biological_processGO:0031959 mineralocorticoid receptor signaling pathway IEA
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0032496 response to lipopolysaccharide ISS
 biological_processGO:0032516 positive regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0032731 positive regulation of interleukin-1 beta production IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production ISS
 biological_processGO:0033160 positive regulation of protein import into nucleus, translocation IEA
 biological_processGO:0033194 response to hydroperoxide IEA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IDA
 biological_processGO:0034612 response to tumor necrosis factor IDA
 biological_processGO:0035409 histone H3-Y41 phosphorylation IDA
 biological_processGO:0035556 intracellular signal transduction ISS
 biological_processGO:0035722 interleukin-12-mediated signaling pathway TAS
 biological_processGO:0038155 interleukin-23-mediated signaling pathway TAS
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein ISS
 biological_processGO:0042976 activation of Janus kinase activity ISS
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043388 positive regulation of DNA binding IEA
 biological_processGO:0043392 negative regulation of DNA binding ISS
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0045597 positive regulation of cell differentiation IEA
 biological_processGO:0045822 negative regulation of heart contraction IEA
 biological_processGO:0046425 regulation of JAK-STAT cascade ISS
 biological_processGO:0046677 response to antibiotic IDA
 biological_processGO:0046777 protein autophosphorylation ISS
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IEA
 biological_processGO:0050727 regulation of inflammatory response IDA
 biological_processGO:0050729 positive regulation of inflammatory response IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ISS
 biological_processGO:0050867 positive regulation of cell activation IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051770 positive regulation of nitric-oxide synthase biosynthetic process ISS
 biological_processGO:0060333 interferon-gamma-mediated signaling pathway TAS
 biological_processGO:0060334 regulation of interferon-gamma-mediated signaling pathway TAS
 biological_processGO:0060396 growth hormone receptor signaling pathway IDA
 biological_processGO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway TAS
 biological_processGO:0060399 positive regulation of growth hormone receptor signaling pathway ISS
 biological_processGO:0061180 mammary gland epithelium development ISS
 biological_processGO:0070102 interleukin-6-mediated signaling pathway TAS
 biological_processGO:0070106 interleukin-27-mediated signaling pathway TAS
 biological_processGO:0070671 response to interleukin-12 IDA
 biological_processGO:0070757 interleukin-35-mediated signaling pathway TAS
 biological_processGO:0097191 extrinsic apoptotic signaling pathway ISS
 biological_processGO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISS
 biological_processGO:1902728 positive regulation of growth factor dependent skeletal muscle satellite cell proliferation IEA
 biological_processGO:1904037 positive regulation of epithelial cell apoptotic process IEA
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005901 caveola ISS
 cellular_componentGO:0005925 focal adhesion IDA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0031904 endosome lumen TAS
 cellular_componentGO:0045121 membrane raft ISS
 molecular_functionGO:0004672 protein kinase activity TAS
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity TAS
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005131 growth hormone receptor binding ISS
 molecular_functionGO:0005143 interleukin-12 receptor binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0019901 protein kinase binding IDA
 molecular_functionGO:0020037 heme binding IDA
 molecular_functionGO:0031702 type 1 angiotensin receptor binding IEA
 molecular_functionGO:0033130 acetylcholine receptor binding IEA
 molecular_functionGO:0035401 histone kinase activity (H3-Y41 specific) IDA
 molecular_functionGO:0042169 SH2 domain binding IPI
 molecular_functionGO:0042393 histone binding IDA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding IEA
 molecular_functionGO:0043560 insulin receptor substrate binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051428 peptide hormone receptor binding IEA


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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