3949


Homo sapiens (NCBI)

Features
Gene ID: 3949
  
Biological name :
  
Synonyms : FH|FHC|LDLCQ2 / LDLR / low density lipoprotein receptor
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 202067_s_at (Human Genome U133 Plus 2.0 Array)   202068_s_at (Human Genome U133 Plus 2.0 Array)   217005_at (Human Genome U133 Plus 2.0 Array)   217103_at (Human Genome U133 Plus 2.0 Array)   217173_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - NP_000518.1
RefSeq - NP_001182727.1
RefSeq - NP_001182728.1
RefSeq - NP_001182729.1
RefSeq - NP_001182732.1
RefSeq - NG_009060.1
RefSeq - XP_011526312.1
RefSeq - 307775414
RefSeq - 307775412
RefSeq - 307775416
RefSeq - 307775422
RefSeq - 4504975
RefSeq - 768002424
RefSeq - NC_000019.10
RefSeq - XR_001753686.2
RefSeq - NM_000527.4
RefSeq - NM_001195798.1
RefSeq - NM_001195799.1
RefSeq - NM_001195800.1
RefSeq - NM_001195802.1
RefSeq - NM_001195803.1
RefSeq - XM_011528010.2
RefSeq - XR_001753685.2
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000130164 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process TAS
 biological_processGO:0006897 endocytosis TAS
 biological_processGO:0006898 receptor-mediated endocytosis ISS
 biological_processGO:0007616 long-term memory IGI
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010867 positive regulation of triglyceride biosynthetic process ISS
 biological_processGO:0010899 regulation of phosphatidylcholine catabolic process ISS
 biological_processGO:0010986 positive regulation of lipoprotein particle clearance ISS
 biological_processGO:0015914 phospholipid transport ISS
 biological_processGO:0030299 intestinal cholesterol absorption IMP
 biological_processGO:0030301 cholesterol transport TAS
 biological_processGO:0034381 plasma lipoprotein particle clearance TAS
 biological_processGO:0034382 chylomicron remnant clearance TAS
 biological_processGO:0034383 low-density lipoprotein particle clearance TAS
 biological_processGO:0042159 lipoprotein catabolic process IEA
 biological_processGO:0042632 cholesterol homeostasis TAS
 biological_processGO:0045807 positive regulation of endocytosis ISS
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0050729 positive regulation of inflammatory response IEA
 biological_processGO:0051246 regulation of protein metabolic process IGI
 biological_processGO:0051248 negative regulation of protein metabolic process ISS
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0061771 response to caloric restriction IGI
 biological_processGO:0061889 negative regulation of astrocyte activation ISS
 biological_processGO:0070508 cholesterol import ISS
 biological_processGO:0071398 cellular response to fatty acid IEA
 biological_processGO:0071404 cellular response to low-density lipoprotein particle stimulus IMP
 biological_processGO:0090118 receptor-mediated endocytosis involved in cholesterol transport IMP
 biological_processGO:0090181 regulation of cholesterol metabolic process IEA
 biological_processGO:0097242 amyloid-beta clearance ISS
 biological_processGO:1900223 positive regulation of amyloid-beta clearance ISS
 biological_processGO:1903979 negative regulation of microglial cell activation ISS
 biological_processGO:1905167 positive regulation of lysosomal protein catabolic process ISS
 biological_processGO:1905907 negative regulation of amyloid fibril formation ISS
 cellular_componentGO:0005622 intracellular ISS
 cellular_componentGO:0005764 lysosome IDA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005770 late endosome IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0005905 clathrin-coated pit IDA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface ISS
 cellular_componentGO:0010008 endosome membrane TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0016323 basolateral plasma membrane ISS
 cellular_componentGO:0030669 clathrin-coated endocytic vesicle membrane TAS
 cellular_componentGO:0034362 low-density lipoprotein particle IEA
 cellular_componentGO:0036020 endolysosome membrane TAS
 cellular_componentGO:0036477 somatodendritic compartment IEA
 cellular_componentGO:0043235 receptor complex IDA
 cellular_componentGO:0045177 apical part of cell ISS
 cellular_componentGO:0097443 sorting endosome IEA
 cellular_componentGO:1990666 PCSK9-LDLR complex IDA
 molecular_functionGO:0001540 amyloid-beta binding IEA
 molecular_functionGO:0001618 virus receptor activity IEA
 molecular_functionGO:0002020 protease binding IPI
 molecular_functionGO:0005041 low-density lipoprotein particle receptor activity TAS
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030169 low-density lipoprotein particle binding IMP
 molecular_functionGO:0030229 very-low-density lipoprotein particle receptor activity IDA
 molecular_functionGO:0032050 clathrin heavy chain binding TAS
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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