3952


Homo sapiens (NCBI)

Features
Gene ID: 3952
  
Biological name :
  
Synonyms : LEP / LEPD|OB|OBS / leptin
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 207092_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 4557715
RefSeq - 530385892
RefSeq - NC_000007.14
RefSeq - NG_007450.1
RefSeq - NP_000221.1
RefSeq - XP_005250397.1
RefSeq - NM_000230.2
RefSeq - XM_005250340.5
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000174697 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001525 angiogenesis IDA
 biological_processGO:0001542 ovulation from ovarian follicle IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001890 placenta development IDA
 biological_processGO:0001936 regulation of endothelial cell proliferation IDA
 biological_processGO:0002021 response to dietary excess IEA
 biological_processGO:0003300 cardiac muscle hypertrophy IEA
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0006111 regulation of gluconeogenesis IEA
 biological_processGO:0006112 energy reserve metabolic process IBA
 biological_processGO:0006114 glycerol biosynthetic process IEA
 biological_processGO:0006629 lipid metabolic process IBA
 biological_processGO:0006635 fatty acid beta-oxidation IEA
 biological_processGO:0006909 phagocytosis IEA
 biological_processGO:0007260 tyrosine phosphorylation of STAT protein IBA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0008206 bile acid metabolic process IEA
 biological_processGO:0008217 regulation of blood pressure IEA
 biological_processGO:0008343 adult feeding behavior ISS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010507 negative regulation of autophagy IDA
 biological_processGO:0010888 negative regulation of lipid storage IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling ISS
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0019953 sexual reproduction IMP
 biological_processGO:0021954 central nervous system neuron development IEA
 biological_processGO:0030073 insulin secretion IEA
 biological_processGO:0030217 T cell differentiation ISS
 biological_processGO:0030300 regulation of intestinal cholesterol absorption IEA
 biological_processGO:0032008 positive regulation of TOR signaling IDA
 biological_processGO:0032099 negative regulation of appetite ISS
 biological_processGO:0032310 prostaglandin secretion IDA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032615 interleukin-12 production IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0032814 regulation of natural killer cell activation IDA
 biological_processGO:0032817 regulation of natural killer cell proliferation IDA
 biological_processGO:0032868 response to insulin IBA
 biological_processGO:0033197 response to vitamin E IEA
 biological_processGO:0033210 leptin-mediated signaling pathway ISS
 biological_processGO:0033686 positive regulation of luteinizing hormone secretion IEA
 biological_processGO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway IEA
 biological_processGO:0035630 bone mineralization involved in bone maturation IEA
 biological_processGO:0038108 negative regulation of appetite by leptin-mediated signaling pathway ISS
 biological_processGO:0042102 positive regulation of T cell proliferation IDA
 biological_processGO:0042269 regulation of natural killer cell mediated cytotoxicity IDA
 biological_processGO:0042307 positive regulation of protein import into nucleus IEA
 biological_processGO:0042445 hormone metabolic process IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0042755 eating behavior IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043270 positive regulation of ion transport IEA
 biological_processGO:0043410 positive regulation of MAPK cascade ISS
 biological_processGO:0044320 cellular response to leptin stimulus IDA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045765 regulation of angiogenesis IDA
 biological_processGO:0045906 negative regulation of vasoconstriction IEA
 biological_processGO:0046325 negative regulation of glucose import IDA
 biological_processGO:0046427 positive regulation of JAK-STAT cascade IDA
 biological_processGO:0046628 positive regulation of insulin receptor signaling pathway IEA
 biological_processGO:0046850 regulation of bone remodeling ISS
 biological_processGO:0046881 positive regulation of follicle-stimulating hormone secretion IEA
 biological_processGO:0048639 positive regulation of developmental growth IDA
 biological_processGO:0050796 regulation of insulin secretion IEA
 biological_processGO:0050810 regulation of steroid biosynthetic process IEA
 biological_processGO:0050892 intestinal absorption IDA
 biological_processGO:0050901 leukocyte tethering or rolling IEA
 biological_processGO:0050999 regulation of nitric-oxide synthase activity IDA
 biological_processGO:0051726 regulation of cell cycle IDA
 biological_processGO:0051897 positive regulation of protein kinase B signaling ISS
 biological_processGO:0060587 regulation of lipoprotein lipid oxidation IEA
 biological_processGO:0060612 adipose tissue development IEA
 biological_processGO:0061037 negative regulation of cartilage development IEA
 biological_processGO:0070093 negative regulation of glucagon secretion IEA
 biological_processGO:0071298 cellular response to L-ascorbic acid IEA
 biological_processGO:0071300 cellular response to retinoic acid IEA
 biological_processGO:0072604 interleukin-6 secretion IDA
 biological_processGO:0072606 interleukin-8 secretion IDA
 biological_processGO:0090335 regulation of brown fat cell differentiation ISS
 biological_processGO:0098868 bone growth ISS
 biological_processGO:1900015 regulation of cytokine production involved in inflammatory response IDA
 biological_processGO:1900745 positive regulation of p38MAPK cascade IDA
 biological_processGO:1904651 positive regulation of fat cell apoptotic process IEA
 biological_processGO:1990051 activation of protein kinase C activity IDA
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IEA
 biological_processGO:2000486 negative regulation of glutamine transport IEA
 biological_processGO:2000491 positive regulation of hepatic stellate cell activation IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005179 hormone activity IBA
 molecular_functionGO:0051428 peptide hormone receptor binding IBA


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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