4089


Homo sapiens (NCBI)

Features
Gene ID: 4089
  
Biological name :
  
Synonyms : DPC4|JIP|MADH4|MYHRS / SMAD4 / SMAD family member 4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1565702_at (Human Genome U133 Plus 2.0 Array)   1565703_at (Human Genome U133 Plus 2.0 Array)   202526_at (Human Genome U133 Plus 2.0 Array)   202527_s_at (Human Genome U133 Plus 2.0 Array)   235725_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 4885457
RefSeq - NC_000018.10
RefSeq - NG_013013.2
RefSeq - NP_005350.1
RefSeq - NM_005359.5
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000141646 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II TAS
 biological_processGO:0001541 ovarian follicle development IEA
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IEA
 biological_processGO:0001666 response to hypoxia IMP
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001702 gastrulation with mouth forming second IEA
 biological_processGO:0003148 outflow tract septum morphogenesis ISS
 biological_processGO:0003190 atrioventricular valve formation IEA
 biological_processGO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation IEA
 biological_processGO:0003220 left ventricular cardiac muscle tissue morphogenesis ISS
 biological_processGO:0003251 positive regulation of cell proliferation involved in heart valve morphogenesis IEA
 biological_processGO:0003360 brainstem development IEA
 biological_processGO:0006879 cellular iron ion homeostasis ISS
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway TAS
 biological_processGO:0007183 SMAD protein complex assembly IDA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007338 single fertilization IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0007492 endoderm development IEA
 biological_processGO:0007498 mesoderm development IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010614 negative regulation of cardiac muscle hypertrophy ISS
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition ISS
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation ISS
 biological_processGO:0014033 neural crest cell differentiation IEA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0017015 regulation of transforming growth factor beta receptor signaling pathway IMP
 biological_processGO:0030308 negative regulation of cell growth IDA
 biological_processGO:0030509 BMP signaling pathway TAS
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0030513 positive regulation of BMP signaling pathway IMP
 biological_processGO:0032525 somite rostral/caudal axis specification IEA
 biological_processGO:0032909 regulation of transforming growth factor beta2 production IMP
 biological_processGO:0033686 positive regulation of luteinizing hormone secretion IEA
 biological_processGO:0035019 somatic stem cell population maintenance TAS
 biological_processGO:0035556 intracellular signal transduction IMP
 biological_processGO:0036302 atrioventricular canal development IEA
 biological_processGO:0042118 endothelial cell activation IEA
 biological_processGO:0042733 embryonic digit morphogenesis IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II TAS
 biological_processGO:0046881 positive regulation of follicle-stimulating hormone secretion IEA
 biological_processGO:0048589 developmental growth IEA
 biological_processGO:0048663 neuron fate commitment IEA
 biological_processGO:0048733 sebaceous gland development IEA
 biological_processGO:0048859 formation of anatomical boundary IEA
 biological_processGO:0051098 regulation of binding IEA
 biological_processGO:0051571 positive regulation of histone H3-K4 methylation ISS
 biological_processGO:0051797 regulation of hair follicle development IEA
 biological_processGO:0060065 uterus development IEA
 biological_processGO:0060391 positive regulation of SMAD protein signal transduction ISS
 biological_processGO:0060395 SMAD protein signal transduction IDA
 biological_processGO:0060412 ventricular septum morphogenesis ISS
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0060956 endocardial cell differentiation IEA
 biological_processGO:0061040 female gonad morphogenesis IEA
 biological_processGO:0061614 pri-miRNA transcription by RNA polymerase II IEA
 biological_processGO:0062009 secondary palate development ISS
 biological_processGO:0070102 interleukin-6-mediated signaling pathway ISS
 biological_processGO:0070207 protein homotrimerization IMP
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade ISS
 biological_processGO:0071559 response to transforming growth factor beta IDA
 biological_processGO:0071773 cellular response to BMP stimulus NAS
 biological_processGO:0072133 metanephric mesenchyme morphogenesis IEA
 biological_processGO:0072134 nephrogenic mesenchyme morphogenesis IEA
 biological_processGO:0072520 seminiferous tubule development IEA
 biological_processGO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus TAS
 biological_processGO:1905305 negative regulation of cardiac myofibril assembly ISS
 biological_processGO:2000617 positive regulation of histone H3-K9 acetylation ISS
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IPI
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0032444 activin responsive factor complex IDA
 cellular_componentGO:0071141 SMAD protein complex IMP
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000989 transcription factor activity, transcription factor binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005518 collagen binding IEA
 molecular_functionGO:0030616 transforming growth factor beta receptor, common-partner cytoplasmic mediator activity IDA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0043199 sulfate binding IMP
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0070411 I-SMAD binding IPI
 molecular_functionGO:0070412 R-SMAD binding IPI


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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