5071


Homo sapiens (NCBI)

Features
Gene ID: 5071
  
Biological name :
  
Synonyms : AR-JP|LPRS2|PARK2|PDJ / parkin RBR E3 ubiquitin protein ligase / PRKN
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1554855_at (Human Genome U133 Plus 2.0 Array)   1555668_a_at (Human Genome U133 Plus 2.0 Array)   207058_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 1034650406
RefSeq - 1034650408
RefSeq - 1370508127
RefSeq - 169790969
RefSeq - 169790971
RefSeq - 169790973
RefSeq - 767942939
RefSeq - NC_000006.12
RefSeq - NG_008289.2
RefSeq - NP_004553.2
RefSeq - NP_054642.2
RefSeq - NP_054643.2
RefSeq - XP_011534165.1
RefSeq - XP_016866397.1
RefSeq - XP_016866398.1
RefSeq - XP_024302217.1
RefSeq - XM_017010908.1
RefSeq - NM_004562.2
RefSeq - NM_013987.2
RefSeq - NM_013988.2
RefSeq - XM_017010909.2
RefSeq - XM_024446449.1
RefSeq - XR_001743443.2
RefSeq - XM_011535863.1
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000185345 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0000209 protein polyubiquitination IDA
 biological_processGO:0000266 mitochondrial fission ISS
 biological_processGO:0000422 autophagy of mitochondrion IMP
 biological_processGO:0000423 mitophagy IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IDA
 biological_processGO:0001964 startle response IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0006513 protein monoubiquitination IMP
 biological_processGO:0006979 response to oxidative stress ISS
 biological_processGO:0007005 mitochondrion organization ISS
 biological_processGO:0007417 central nervous system development TAS
 biological_processGO:0007612 learning IEA
 biological_processGO:0008344 adult locomotory behavior ISS
 biological_processGO:0010498 proteasomal protein catabolic process IMP
 biological_processGO:0010506 regulation of autophagy IDA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0010636 positive regulation of mitochondrial fusion IMP
 biological_processGO:0010637 negative regulation of mitochondrial fusion ISS
 biological_processGO:0010821 regulation of mitochondrion organization NAS
 biological_processGO:0010906 regulation of glucose metabolic process TAS
 biological_processGO:0010994 free ubiquitin chain polymerization IMP
 biological_processGO:0014059 regulation of dopamine secretion TAS
 biological_processGO:0016236 macroautophagy TAS
 biological_processGO:0016567 protein ubiquitination IMP
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0031396 regulation of protein ubiquitination IMP
 biological_processGO:0031647 regulation of protein stability IMP
 biological_processGO:0031648 protein destabilization IDA
 biological_processGO:0032092 positive regulation of protein binding IMP
 biological_processGO:0032232 negative regulation of actin filament bundle assembly IDA
 biological_processGO:0032368 regulation of lipid transport TAS
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0033132 negative regulation of glucokinase activity IDA
 biological_processGO:0034620 cellular response to unfolded protein TAS
 biological_processGO:0034976 response to endoplasmic reticulum stress IMP
 biological_processGO:0035249 synaptic transmission, glutamatergic IEA
 biological_processGO:0035519 protein K29-linked ubiquitination TAS
 biological_processGO:0036503 ERAD pathway NAS
 biological_processGO:0042053 regulation of dopamine metabolic process IMP
 biological_processGO:0042415 norepinephrine metabolic process IEA
 biological_processGO:0042417 dopamine metabolic process TAS
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0043388 positive regulation of DNA binding IDA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IDA
 biological_processGO:0044257 cellular protein catabolic process IMP
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0044314 protein K27-linked ubiquitination TAS
 biological_processGO:0044828 negative regulation by host of viral genome replication IDA
 biological_processGO:0045732 positive regulation of protein catabolic process TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046329 negative regulation of JNK cascade ISS
 biological_processGO:0046676 negative regulation of insulin secretion IDA
 biological_processGO:0050821 protein stabilization IMP
 biological_processGO:0051582 positive regulation of neurotransmitter uptake IMP
 biological_processGO:0051583 dopamine uptake involved in synaptic transmission IEA
 biological_processGO:0051865 protein autoubiquitination IDA
 biological_processGO:0051881 regulation of mitochondrial membrane potential IEA
 biological_processGO:0055069 zinc ion homeostasis ISS
 biological_processGO:0060548 negative regulation of cell death IDA
 biological_processGO:0060828 regulation of canonical Wnt signaling pathway TAS
 biological_processGO:0061734 parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization IDA
 biological_processGO:0070050 neuron cellular homeostasis ISS
 biological_processGO:0070534 protein K63-linked ubiquitination TAS
 biological_processGO:0070585 protein localization to mitochondrion IEA
 biological_processGO:0070842 aggresome assembly IMP
 biological_processGO:0070936 protein K48-linked ubiquitination IDA
 biological_processGO:0070979 protein K11-linked ubiquitination IDA
 biological_processGO:0071287 cellular response to manganese ion TAS
 biological_processGO:0085020 protein K6-linked ubiquitination TAS
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway TAS
 biological_processGO:0090141 positive regulation of mitochondrial fission ISS
 biological_processGO:0090201 negative regulation of release of cytochrome c from mitochondria IDA
 biological_processGO:0097237 cellular response to toxic substance IMP
 biological_processGO:0098779 positive regulation of mitophagy in response to mitochondrial depolarization IMP
 biological_processGO:0099074 mitochondrion to lysosome transport IDA
 biological_processGO:1900407 regulation of cellular response to oxidative stress ISS
 biological_processGO:1901215 negative regulation of neuron death IGI
 biological_processGO:1901800 positive regulation of proteasomal protein catabolic process IGI
 biological_processGO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
 biological_processGO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator IMP
 biological_processGO:1902283 negative regulation of primary amine oxidase activity IMP
 biological_processGO:1902530 positive regulation of protein linear polyubiquitination IGI
 biological_processGO:1902803 regulation of synaptic vesicle transport NAS
 biological_processGO:1903202 negative regulation of oxidative stress-induced cell death TAS
 biological_processGO:1903214 regulation of protein targeting to mitochondrion NAS
 biological_processGO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway IDA
 biological_processGO:1903351 cellular response to dopamine TAS
 biological_processGO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IDA
 biological_processGO:1903382 negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway IEA
 biological_processGO:1903542 negative regulation of exosomal secretion IMP
 biological_processGO:1903599 positive regulation of autophagy of mitochondrion IDA
 biological_processGO:1903861 positive regulation of dendrite extension IEA
 biological_processGO:1904049 negative regulation of spontaneous neurotransmitter secretion IMP
 biological_processGO:1905281 positive regulation of retrograde transport, endosome to Golgi NAS
 biological_processGO:1905366 negative regulation of intralumenal vesicle formation IMP
 biological_processGO:1905477 positive regulation of protein localization to membrane IMP
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IMP
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IGI
 cellular_componentGO:0000151 ubiquitin ligase complex IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion IMP
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016235 aggresome IDA
 cellular_componentGO:0016607 nuclear speck IDA
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IDA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0071797 LUBAC complex IPI
 cellular_componentGO:0097413 Lewy body TAS
 cellular_componentGO:0098793 presynapse IEA
 cellular_componentGO:0099073 mitochondrion-derived vesicle IDA
 cellular_componentGO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex IPI
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001664 G-protein coupled receptor binding IPI
 molecular_functionGO:0003700 DNA-binding transcription factor activity IC
 molecular_functionGO:0003779 actin binding IPI
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IDA
 molecular_functionGO:0008270 zinc ion binding TAS
 molecular_functionGO:0015631 tubulin binding IPI
 molecular_functionGO:0017124 SH3 domain binding TAS
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019900 kinase binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0030165 PDZ domain binding IPI
 molecular_functionGO:0030544 Hsp70 protein binding IPI
 molecular_functionGO:0031072 heat shock protein binding IPI
 molecular_functionGO:0031624 ubiquitin conjugating enzyme binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0043130 ubiquitin binding IDA
 molecular_functionGO:0043274 phospholipase binding IPI
 molecular_functionGO:0051087 chaperone binding IPI
 molecular_functionGO:0061630 ubiquitin protein ligase activity TAS
 molecular_functionGO:0097602 cullin family protein binding IDA
 molecular_functionGO:1990381 ubiquitin-specific protease binding IPI
 molecular_functionGO:1990444 F-box domain binding IPI


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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