5663


Homo sapiens (NCBI)

Features
Gene ID: 5663
  
Biological name :
  
Synonyms : ACNINV3|AD3|FAD|PS-1|PS1|S182 / presenilin 1 / PSEN1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1559206_at (Human Genome U133 Plus 2.0 Array)   1567440_at (Human Genome U133 Plus 2.0 Array)   1567443_x_at (Human Genome U133 Plus 2.0 Array)   203460_s_at (Human Genome U133 Plus 2.0 Array)   207782_s_at (Human Genome U133 Plus 2.0 Array)   226577_at (Human Genome U133 Plus 2.0 Array)   238816_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - XP_011535276.1
RefSeq - 4506163
RefSeq - 530404202
RefSeq - 530404206
RefSeq - 767981053
RefSeq - 767981055
RefSeq - 767981057
RefSeq - NC_000014.9
RefSeq - NG_007386.2
RefSeq - NP_000012.1
RefSeq - NP_015557.2
RefSeq - XP_005267921.1
RefSeq - XP_005267923.1
RefSeq - XP_011535274.1
RefSeq - XP_011535275.1
RefSeq - 195947397
RefSeq - XM_011536972.2
RefSeq - NM_000021.3
RefSeq - NM_007318.2
RefSeq - NM_007319.1
RefSeq - XM_011536973.2
RefSeq - XM_011536974.2
RefSeq - XM_005267864.3
RefSeq - XM_005267866.2
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000080815 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000045 autophagosome assembly IEA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0001568 blood vessel development IEA
 biological_processGO:0001708 cell fate specification IEA
 biological_processGO:0001756 somitogenesis IEA
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0001921 positive regulation of receptor recycling IEA
 biological_processGO:0001947 heart looping IEA
 biological_processGO:0002038 positive regulation of L-glutamate import across plasma membrane IEA
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IEA
 biological_processGO:0002265 astrocyte activation involved in immune response IGI
 biological_processGO:0002286 T cell activation involved in immune response IEA
 biological_processGO:0003407 neural retina development IEA
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0006509 membrane protein ectodomain proteolysis IDA
 biological_processGO:0006839 mitochondrial transport IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007175 negative regulation of epidermal growth factor-activated receptor activity IEA
 biological_processGO:0007219 Notch signaling pathway TAS
 biological_processGO:0007220 Notch receptor processing TAS
 biological_processGO:0007611 learning or memory TAS
 biological_processGO:0007613 memory IGI
 biological_processGO:0009791 post-embryonic development IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0015871 choline transport IEA
 biological_processGO:0016080 synaptic vesicle targeting IEA
 biological_processGO:0016485 protein processing IDA
 biological_processGO:0021795 cerebral cortex cell migration IEA
 biological_processGO:0021870 Cajal-Retzius cell differentiation IEA
 biological_processGO:0021904 dorsal/ventral neural tube patterning IEA
 biological_processGO:0030326 embryonic limb morphogenesis IEA
 biological_processGO:0032092 positive regulation of protein binding IGI
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0032469 endoplasmic reticulum calcium ion homeostasis IGI
 biological_processGO:0033160 positive regulation of protein import into nucleus, translocation IMP
 biological_processGO:0034205 amyloid-beta formation IMP
 biological_processGO:0035333 Notch receptor processing, ligand-dependent TAS
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042325 regulation of phosphorylation IDA
 biological_processGO:0042327 positive regulation of phosphorylation IGI
 biological_processGO:0042982 amyloid precursor protein metabolic process IDA
 biological_processGO:0042987 amyloid precursor protein catabolic process TAS
 biological_processGO:0043011 myeloid dendritic cell differentiation IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043085 positive regulation of catalytic activity IDA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0043589 skin morphogenesis IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0048143 astrocyte activation IGI
 biological_processGO:0048167 regulation of synaptic plasticity IEA
 biological_processGO:0048538 thymus development IEA
 biological_processGO:0048666 neuron development IEA
 biological_processGO:0048705 skeletal system morphogenesis IEA
 biological_processGO:0048854 brain morphogenesis IEA
 biological_processGO:0050673 epithelial cell proliferation IEA
 biological_processGO:0050771 negative regulation of axonogenesis IEA
 biological_processGO:0050808 synapse organization IGI
 biological_processGO:0050820 positive regulation of coagulation IEA
 biological_processGO:0050852 T cell receptor signaling pathway IEA
 biological_processGO:0051402 neuron apoptotic process IEA
 biological_processGO:0051444 negative regulation of ubiquitin-protein transferase activity IEA
 biological_processGO:0051563 smooth endoplasmic reticulum calcium ion homeostasis IBA
 biological_processGO:0051966 regulation of synaptic transmission, glutamatergic IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IBA
 biological_processGO:0060075 regulation of resting membrane potential IEA
 biological_processGO:0060828 regulation of canonical Wnt signaling pathway ISS
 biological_processGO:0060999 positive regulation of dendritic spine development IMP
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0090647 modulation of age-related behavioral decline TAS
 biological_processGO:0098609 cell-cell adhesion IMP
 biological_processGO:1904646 cellular response to amyloid-beta IGI
 biological_processGO:1904797 negative regulation of core promoter binding IMP
 biological_processGO:1905598 negative regulation of low-density lipoprotein receptor activity IGI
 biological_processGO:1905908 positive regulation of amyloid fibril formation IGI
 biological_processGO:1990535 neuron projection maintenance IGI
 biological_processGO:2000059 negative regulation of ubiquitin-dependent protein catabolic process IEA
 biological_processGO:2001234 negative regulation of apoptotic signaling pathway IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0000776 kinetochore IDA
 cellular_componentGO:0005634 nucleus IMP
 cellular_componentGO:0005640 nuclear outer membrane IDA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005790 smooth endoplasmic reticulum IDA
 cellular_componentGO:0005791 rough endoplasmic reticulum IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane TAS
 cellular_componentGO:0016235 aggresome IDA
 cellular_componentGO:0030054 cell junction IDA
 cellular_componentGO:0031965 nuclear membrane IDA
 cellular_componentGO:0032991 protein-containing complex IMP
 cellular_componentGO:0035577 azurophil granule membrane TAS
 cellular_componentGO:0045121 membrane raft IDA
 cellular_componentGO:0070765 gamma-secretase complex IDA
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0004175 endopeptidase activity IDA
 molecular_functionGO:0004190 aspartic-type endopeptidase activity TAS
 molecular_functionGO:0005262 calcium channel activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IPI
 molecular_functionGO:0030165 PDZ domain binding IPI
 molecular_functionGO:0042500 aspartic endopeptidase activity, intramembrane cleaving IDA
 molecular_functionGO:0045296 cadherin binding IBA


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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