64321


Homo sapiens (NCBI)
regulationtranscriptioncelldevelopmentbindingrnapolymeraseiimorphogenesisheartfatefactorproteinactivityembryonicinvolvedspecificationsequence-specificdnaformationtubewntsignalingpathwayendodermaldifferentiationstemcellulartractdna-templated

Features
Gene ID: 64321
  
Biological name :
  
Synonyms : SOX17 / SRY-box 17 / VUR3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 219993_at (Human Genome U133 Plus 2.0 Array)   230943_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 11967991
RefSeq - NC_000008.11
RefSeq - NG_028171.1
RefSeq - NP_071899.1
RefSeq - NM_022454.3
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000164736 to get all the annotations available for this gene.


Gene Ontology (GO)
nitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processcellular component organizationcell communicationcellular response to stimulusmulticellular organism reproductioncell growthregulation of biological qualitylocalization of cellmovement of cell or subcellular componentcatabolic processstem cell proliferationresponse to chemicalcell divisionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processcellular component organizationcell communicationcellular response to stimulusmulticellular organism reproductioncell growthregulation of biological qualitylocalization of cellmovement of cell or subcellular componentcatabolic processstem cell proliferationresponse to chemicalcell divisionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processcellular component organizationcell communicationcellular response to stimulusmulticellular organism reproductioncell growthregulation of biological qualitylocalization of cellmovement of cell or subcellular componentcatabolic processstem cell proliferationresponse to chemicalcell divisionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processcellular component organizationcell communicationcellular response to stimulusmulticellular organism reproductioncell growthregulation of biological qualitylocalization of cellmovement of cell or subcellular componentcatabolic processstem cell proliferationresponse to chemicalcell divisionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processcellular component organizationcell communicationcellular response to stimulusmulticellular organism reproductioncell growthregulation of biological qualitylocalization of cellmovement of cell or subcellular componentcatabolic processstem cell proliferationresponse to chemicalcell divisionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processcellular component organizationcell communicationcellular response to stimulusmulticellular organism reproductioncell growthregulation of biological qualitylocalization of cellmovement of cell or subcellular componentcatabolic processstem cell proliferationresponse to chemicalcell divisionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processcellular component organizationcell communicationcellular response to stimulusmulticellular organism reproductioncell growthregulation of biological qualitylocalization of cellmovement of cell or subcellular componentcatabolic processstem cell proliferationresponse to chemicalcell divisionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processcellular component organizationcell communicationcellular response to stimulusmulticellular organism reproductioncell growthregulation of biological qualitylocalization of cellmovement of cell or subcellular componentcatabolic processstem cell proliferationresponse to chemicalcell divisionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processcellular component organizationcell communicationcellular response to stimulusmulticellular organism reproductioncell growthregulation of biological qualitylocalization of cellmovement of cell or subcellular componentcatabolic processstem cell proliferationresponse to chemicalcell divisionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processcellular component organizationcell communicationcellular response to stimulusmulticellular organism reproductioncell growthregulation of biological qualitylocalization of cellmovement of cell or subcellular componentcatabolic processstem cell proliferationresponse to chemicalcell divisionnitrogenitrogen compound metabolic processbiosyntbiosynthetic processcellulacellular metabolic processprimaryprimary metabolic processorganicorganic substance metabolic processanatomianatomical structure developmentcellulacellular developmental processcellulacellular component organizationcell cocell communicationcellulacellular response to stimulusmulticemulticellular organism reproductioncell grcell growthregulatregulation of biological qualitylocalizlocalization of cellmovemenmovement of cell or subcellular componentcatabolcatabolic processstem cestem cell proliferationresponsresponse to chemicalcell dicell division
DNA-binding transcription factor activitytranscription coregulator activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription faDNA-binding transcription factor activitytranscription coregulator actranscription coregulator activityprotein bindingprotein bindingorganic cyclic compound bindorganic cyclic compound bindingheterocyclic compound bindinheterocyclic compound binding
cellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001525 angiogenesis ISS
 biological_processGO:0001568 blood vessel development IBA
 biological_processGO:0001570 vasculogenesis ISS
 biological_processGO:0001706 endoderm formation IDA
 biological_processGO:0001828 inner cell mass cellular morphogenesis IEA
 biological_processGO:0001947 heart looping ISS
 biological_processGO:0003142 cardiogenic plate morphogenesis ISS
 biological_processGO:0003143 embryonic heart tube morphogenesis ISS
 biological_processGO:0003151 outflow tract morphogenesis ISS
 biological_processGO:0003308 negative regulation of Wnt signaling pathway involved in heart development IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISS
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007493 endodermal cell fate determination IEA
 biological_processGO:0007507 heart development IBA
 biological_processGO:0009653 anatomical structure morphogenesis IBA
 biological_processGO:0021903 rostrocaudal neural tube patterning IEA
 biological_processGO:0023019 signal transduction involved in regulation of gene expression IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0030308 negative regulation of cell growth IMP
 biological_processGO:0031648 protein destabilization IMP
 biological_processGO:0035050 embryonic heart tube development ISS
 biological_processGO:0042074 cell migration involved in gastrulation IEA
 biological_processGO:0042662 negative regulation of mesodermal cell fate specification IEA
 biological_processGO:0042789 mRNA transcription by RNA polymerase II IDA
 biological_processGO:0045597 positive regulation of cell differentiation IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0045995 regulation of embryonic development ISS
 biological_processGO:0048617 embryonic foregut morphogenesis ISS
 biological_processGO:0048643 positive regulation of skeletal muscle tissue development IEA
 biological_processGO:0048866 stem cell fate specification IEA
 biological_processGO:0050821 protein stabilization IMP
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060214 endocardium formation ISS
 biological_processGO:0060807 regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification ISS
 biological_processGO:0060913 cardiac cell fate determination IMP
 biological_processGO:0060914 heart formation TAS
 biological_processGO:0060956 endocardial cell differentiation ISS
 biological_processGO:0061009 common bile duct development IEA
 biological_processGO:0061010 gall bladder development IEA
 biological_processGO:0061031 endodermal digestive tract morphogenesis ISS
 biological_processGO:0072001 renal system development IMP
 biological_processGO:0072091 regulation of stem cell proliferation IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IMP
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 biological_processGO:2000035 regulation of stem cell division IEA
 biological_processGO:2000043 regulation of cardiac cell fate specification IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0044798 nuclear transcription factor complex IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding ISS
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISS
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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