6464


Homo sapiens (NCBI)
receptorbindingsignalingpathwayregulationgrowthproteinfactoractivitykinaseepidermalmapkcascadetyrosine-mediatedresponsetransmembranerasinsulinprocessinterleukin-transcriptiondna-templatederkactivationangiogenesisfactor-activatedsignaltransductionaxon

Features
Gene ID: 6464
  
Biological name :
  
Synonyms : SHC1 / SHC adaptor protein 1 / SHC|SHCA
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 201469_s_at (Human Genome U133 Plus 2.0 Array)   214853_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 767910197
RefSeq - 1034561053
RefSeq - 1034561056
RefSeq - 1370454200
RefSeq - 1370454202
RefSeq - 194239662
RefSeq - 194239664
RefSeq - 194239668
RefSeq - 322302755
RefSeq - 32261324
RefSeq - 530365298
RefSeq - 530365302
RefSeq - 1034561051
RefSeq - 767910199
RefSeq - 767910201
RefSeq - 767910208
RefSeq - 767910210
RefSeq - NC_000001.11
RefSeq - NG_029028.1
RefSeq - NP_001123512.1
RefSeq - NP_001123513.1
RefSeq - NP_001189788.1
RefSeq - NP_003020.2
RefSeq - NP_892113.4
RefSeq - XP_005245506.1
RefSeq - XP_005245508.1
RefSeq - XP_011508194.1
RefSeq - XP_011508195.1
RefSeq - XP_011508196.1
RefSeq - XP_011508199.1
RefSeq - XP_011508200.1
RefSeq - XP_016857570.1
RefSeq - XP_016857571.1
RefSeq - XP_016857572.1
RefSeq - XP_024304851.1
RefSeq - XP_024304852.1
RefSeq - NM_001130040.1
RefSeq - NM_001130041.1
RefSeq - NM_001202859.1
RefSeq - NM_003029.4
RefSeq - NM_183001.4
RefSeq - XM_017002081.2
RefSeq - XM_017002082.2
RefSeq - XM_017002083.1
RefSeq - XM_024449083.1
RefSeq - XM_024449084.1
RefSeq - XM_005245449.5
RefSeq - XM_005245451.4
RefSeq - XM_011509892.3
RefSeq - XM_011509893.3
RefSeq - XM_011509894.3
RefSeq - XM_011509897.1
RefSeq - XM_011509898.2
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000160691 to get all the annotations available for this gene.


Gene Ontology (GO)
nitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusregulation of molecular functionanatomical structure developmentresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentcellular developmental processresponse to endogenous stimulusinterspecies interaction between organismsactin filament-based processresponse to stressimmune responseresponse to biotic stimuluscell deathbiosynthetic processlocalization of cellcell adhesionnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusregulation of molecular functionanatomical structure developmentresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentcellular developmental processresponse to endogenous stimulusinterspecies interaction between organismsactin filament-based processresponse to stressimmune responseresponse to biotic stimuluscell deathbiosynthetic processlocalization of cellcell adhesionnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusregulation of molecular functionanatomical structure developmentresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentcellular developmental processresponse to endogenous stimulusinterspecies interaction between organismsactin filament-based processresponse to stressimmune responseresponse to biotic stimuluscell deathbiosynthetic processlocalization of cellcell adhesionnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusregulation of molecular functionanatomical structure developmentresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentcellular developmental processresponse to endogenous stimulusinterspecies interaction between organismsactin filament-based processresponse to stressimmune responseresponse to biotic stimuluscell deathbiosynthetic processlocalization of cellcell adhesionnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusregulation of molecular functionanatomical structure developmentresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentcellular developmental processresponse to endogenous stimulusinterspecies interaction between organismsactin filament-based processresponse to stressimmune responseresponse to biotic stimuluscell deathbiosynthetic processlocalization of cellcell adhesionnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusregulation of molecular functionanatomical structure developmentresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentcellular developmental processresponse to endogenous stimulusinterspecies interaction between organismsactin filament-based processresponse to stressimmune responseresponse to biotic stimuluscell deathbiosynthetic processlocalization of cellcell adhesionnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusregulation of molecular functionanatomical structure developmentresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentcellular developmental processresponse to endogenous stimulusinterspecies interaction between organismsactin filament-based processresponse to stressimmune responseresponse to biotic stimuluscell deathbiosynthetic processlocalization of cellcell adhesionnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusregulation of molecular functionanatomical structure developmentresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentcellular developmental processresponse to endogenous stimulusinterspecies interaction between organismsactin filament-based processresponse to stressimmune responseresponse to biotic stimuluscell deathbiosynthetic processlocalization of cellcell adhesionnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusregulation of molecular functionanatomical structure developmentresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentcellular developmental processresponse to endogenous stimulusinterspecies interaction between organismsactin filament-based processresponse to stressimmune responseresponse to biotic stimuluscell deathbiosynthetic processlocalization of cellcell adhesionnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusregulation of molecular functionanatomical structure developmentresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentcellular developmental processresponse to endogenous stimulusinterspecies interaction between organismsactin filament-based processresponse to stressimmune responseresponse to biotic stimuluscell deathbiosynthetic processlocalization of cellcell adhesionnitrognitrogen compound metabolic processcell ccell communicationcellulcellular metabolic processprimarprimary metabolic processorganiorganic substance metabolic processcellulcellular response to stimulusregularegulation of molecular functionanatomanatomical structure developmentresponresponse to external stimuluscellulcellular component organizationresponresponse to chemicalmovememovement of cell or subcellular componentcellulcellular developmental processresponresponse to endogenous stimulusintersinterspecies interaction between organismsactin actin filament-based processresponresponse to stressimmuneimmune responseresponresponse to biotic stimuluscell dcell deathbiosynbiosynthetic processlocalilocalization of cellcell acell adhesion
protein bindingmolecular adaptor activityprotein-containing complex bindinglipid bindingion bindinghormone bindingprotein bindingmolecular adaptor activityprotein-containing complex bindinglipid bindingion bindinghormone bindingprotein bindingmolecular adaptor activityprotein-containing complex bindinglipid bindingion bindinghormone bindingprotein bindingmolecular adaptor activityprotein-containing complex bindinglipid bindingion bindinghormone bindingprotein bindingmolecular adaptor activityprotein-containing complex bindinglipid bindingion bindinghormone bindingprotein bindingmolecular adaptor activityprotein-containing complex bindinglipid bindingion bindinghormone bindingprotein bindingmolecular adaptor activityprotein-containing complex bindinglipid bindingion bindinghormone bindingprotein bindingmolecular adaptor activityprotein-containing complex bindinglipid bindingion bindinghormone bindingprotein bindingmolecular adaptor activityprotein-containing complex bindinglipid bindingion bindinghormone bindingprotein bindingmolecular adaptor activityprotein-containing complex bindinglipid bindingion bindinghormone bindingprotein bindingprotein bindingmolecular adaptor activmolecular adaptor activityprotein-containing compprotein-containing complex bindinglipid bindinglipid bindingion bindingion bindinghormone bindinghormone binding
cellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenmembranemembraneprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0000187 activation of MAPK activity IMP
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway TAS
 biological_processGO:0007176 regulation of epidermal growth factor-activated receptor activity TAS
 biological_processGO:0007265 Ras protein signal transduction TAS
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008284 positive regulation of cell proliferation NAS
 biological_processGO:0008286 insulin receptor signaling pathway TAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0031532 actin cytoskeleton reorganization IEA
 biological_processGO:0035723 interleukin-15-mediated signaling pathway TAS
 biological_processGO:0036498 IRE1-mediated unfolded protein response TAS
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0038110 interleukin-2-mediated signaling pathway TAS
 biological_processGO:0038128 ERBB2 signaling pathway TAS
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043410 positive regulation of MAPK cascade IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0071363 cellular response to growth factor stimulus IDA
 biological_processGO:0098609 cell-cell adhesion IEA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0070435 Shc-EGFR complex ISS
 molecular_functionGO:0001784 phosphotyrosine residue binding IPI
 molecular_functionGO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity TAS
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005154 epidermal growth factor receptor binding ISS
 molecular_functionGO:0005158 insulin receptor binding IPI
 molecular_functionGO:0005159 insulin-like growth factor receptor binding IPI
 molecular_functionGO:0005168 neurotrophin TRKA receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005543 phospholipid binding TAS
 molecular_functionGO:0019901 protein kinase binding IBA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IBA
 molecular_functionGO:0046875 ephrin receptor binding IPI
 molecular_functionGO:0048408 epidermal growth factor binding IEA


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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