65018


Homo sapiens (NCBI)

Features
Gene ID: 65018
  
Biological name :
  
Synonyms : BRPK|PARK6 / PINK1 / PTEN induced putative kinase 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 209018_s_at (Human Genome U133 Plus 2.0 Array)   209019_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 14165272
RefSeq - NC_000001.11
RefSeq - NG_008164.1
RefSeq - NP_115785.1
RefSeq - NM_032409.2
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000158828 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000422 autophagy of mitochondrion IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0002082 regulation of oxidative phosphorylation IDA
 biological_processGO:0002931 response to ischemia IEA
 biological_processGO:0006468 protein phosphorylation TAS
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0006979 response to oxidative stress IGI
 biological_processGO:0007005 mitochondrion organization IMP
 biological_processGO:0010310 regulation of hydrogen peroxide metabolic process IEA
 biological_processGO:0010629 negative regulation of gene expression ISS
 biological_processGO:0010821 regulation of mitochondrion organization IMP
 biological_processGO:0010952 positive regulation of peptidase activity TAS
 biological_processGO:0016236 macroautophagy TAS
 biological_processGO:0016239 positive regulation of macroautophagy IMP
 biological_processGO:0016242 negative regulation of macroautophagy IMP
 biological_processGO:0016567 protein ubiquitination IMP
 biological_processGO:0018105 peptidyl-serine phosphorylation TAS
 biological_processGO:0022904 respiratory electron transport chain IEA
 biological_processGO:0031396 regulation of protein ubiquitination IMP
 biological_processGO:0031398 positive regulation of protein ubiquitination ISS
 biological_processGO:0032148 activation of protein kinase B activity IC
 biological_processGO:0032226 positive regulation of synaptic transmission, dopaminergic IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation TAS
 biological_processGO:0033603 positive regulation of dopamine secretion IEA
 biological_processGO:0034599 cellular response to oxidative stress IMP
 biological_processGO:0035307 positive regulation of protein dephosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0036289 peptidyl-serine autophosphorylation TAS
 biological_processGO:0038203 TORC2 signaling IC
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0043254 regulation of protein complex assembly IDA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0046329 negative regulation of JNK cascade TAS
 biological_processGO:0050821 protein stabilization IMP
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051443 positive regulation of ubiquitin-protein transferase activity TAS
 biological_processGO:0051881 regulation of mitochondrial membrane potential IMP
 biological_processGO:0051897 positive regulation of protein kinase B signaling IC
 biological_processGO:0061136 regulation of proteasomal protein catabolic process NAS
 biological_processGO:0071456 cellular response to hypoxia IMP
 biological_processGO:0072655 establishment of protein localization to mitochondrion IMP
 biological_processGO:0072656 maintenance of protein location in mitochondrion IMP
 biological_processGO:0090141 positive regulation of mitochondrial fission IBA
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria IMP
 biological_processGO:0090258 negative regulation of mitochondrial fission IMP
 biological_processGO:0097237 cellular response to toxic substance TAS
 biological_processGO:0098779 positive regulation of mitophagy in response to mitochondrial depolarization IMP
 biological_processGO:0099074 mitochondrion to lysosome transport IMP
 biological_processGO:1900407 regulation of cellular response to oxidative stress IMP
 biological_processGO:1901727 positive regulation of histone deacetylase activity IEA
 biological_processGO:1902803 regulation of synaptic vesicle transport TAS
 biological_processGO:1902902 negative regulation of autophagosome assembly IMP
 biological_processGO:1902958 positive regulation of mitochondrial electron transport, NADH to ubiquinone TAS
 biological_processGO:1903146 regulation of autophagy of mitochondrion TAS
 biological_processGO:1903147 negative regulation of autophagy of mitochondrion IMP
 biological_processGO:1903202 negative regulation of oxidative stress-induced cell death IDA
 biological_processGO:1903204 negative regulation of oxidative stress-induced neuron death TAS
 biological_processGO:1903214 regulation of protein targeting to mitochondrion IMP
 biological_processGO:1903298 negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway IEA
 biological_processGO:1903384 negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway IMP
 biological_processGO:1903751 negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide IDA
 biological_processGO:1903852 positive regulation of cristae formation IMP
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion HMP
 biological_processGO:1904544 positive regulation of free ubiquitin chain polymerization ISS
 biological_processGO:1904783 positive regulation of NMDA glutamate receptor activity IEA
 biological_processGO:1904881 cellular response to hydrogen sulfide IEA
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IMP
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IMP
 biological_processGO:2001171 positive regulation of ATP biosynthetic process TAS
 biological_processGO:2001243 negative regulation of intrinsic apoptotic signaling pathway IDA
 cellular_componentGO:0000151 ubiquitin ligase complex ISS
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion IMP
 cellular_componentGO:0005741 mitochondrial outer membrane TAS
 cellular_componentGO:0005742 mitochondrial outer membrane translocase complex IMP
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0005758 mitochondrial intermembrane space TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0031307 integral component of mitochondrial outer membrane IDA
 cellular_componentGO:0031932 TORC2 complex IPI
 cellular_componentGO:0044297 cell body IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0097413 Lewy body TAS
 cellular_componentGO:0097449 astrocyte projection IDA
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0002020 protease binding TAS
 molecular_functionGO:0004672 protein kinase activity IMP
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0010857 calcium-dependent protein kinase activity IDA
 molecular_functionGO:0016301 kinase activity NAS
 molecular_functionGO:0016504 peptidase activator activity TAS
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0043422 protein kinase B binding IDA
 molecular_functionGO:0055131 C3HC4-type RING finger domain binding IPI


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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