652


Homo sapiens (NCBI)

Features
Gene ID: 652
  
Biological name :
  
Synonyms : BMP2B|BMP2B1|MCOPS6|OFC11|ZYME / BMP4 / bone morphogenetic protein 4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 211518_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 1122780682
RefSeq - 1122780734
RefSeq - 1122781077
RefSeq - 1122781519
RefSeq - 1122781552
RefSeq - 1122781626
RefSeq - 157276593
RefSeq - 157276595
RefSeq - 157276597
RefSeq - NC_000014.9
RefSeq - NG_009215.1
RefSeq - NP_001193.2
RefSeq - NP_001334841.1
RefSeq - NP_001334842.1
RefSeq - NP_001334843.1
RefSeq - NP_001334844.1
RefSeq - NP_001334845.1
RefSeq - NP_001334846.1
RefSeq - NP_570911.2
RefSeq - NP_570912.2
RefSeq - NM_001202.5
RefSeq - NM_001347912.1
RefSeq - NM_001347913.1
RefSeq - NM_001347914.1
RefSeq - NM_001347915.1
RefSeq - NM_001347916.1
RefSeq - NM_001347917.1
RefSeq - NM_130850.4
RefSeq - NM_130851.3
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000125378 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0000186 activation of MAPKK activity IDA
 biological_processGO:0001649 osteoblast differentiation IDA
 biological_processGO:0001657 ureteric bud development IDA
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IDA
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0001823 mesonephros development IEP
 biological_processGO:0001843 neural tube closure IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IDA
 biological_processGO:0001958 endochondral ossification ISS
 biological_processGO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis IDA
 biological_processGO:0002062 chondrocyte differentiation ISS
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IDA
 biological_processGO:0002320 lymphoid progenitor cell differentiation IMP
 biological_processGO:0003014 renal system process IEA
 biological_processGO:0003130 BMP signaling pathway involved in heart induction IMP
 biological_processGO:0003139 secondary heart field specification IMP
 biological_processGO:0003148 outflow tract septum morphogenesis ISS
 biological_processGO:0003149 membranous septum morphogenesis ISS
 biological_processGO:0003150 muscular septum morphogenesis ISS
 biological_processGO:0003180 aortic valve morphogenesis ISS
 biological_processGO:0003184 pulmonary valve morphogenesis ISS
 biological_processGO:0003197 endocardial cushion development ISS
 biological_processGO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation ISS
 biological_processGO:0003215 cardiac right ventricle morphogenesis ISS
 biological_processGO:0003277 apoptotic process involved in endocardial cushion morphogenesis ISS
 biological_processGO:0003279 cardiac septum development TAS
 biological_processGO:0003323 type B pancreatic cell development IDA
 biological_processGO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis IDA
 biological_processGO:0007182 common-partner SMAD protein phosphorylation IDA
 biological_processGO:0007224 smoothened signaling pathway IEP
 biological_processGO:0007281 germ cell development IEA
 biological_processGO:0007492 endoderm development IEA
 biological_processGO:0007500 mesodermal cell fate determination IEA
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0009791 post-embryonic development IDA
 biological_processGO:0009948 anterior/posterior axis specification IEA
 biological_processGO:0010159 specification of animal organ position IEA
 biological_processGO:0010453 regulation of cell fate commitment IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IDA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010629 negative regulation of gene expression IDA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IMP
 biological_processGO:0010942 positive regulation of cell death IDA
 biological_processGO:0021537 telencephalon development IDA
 biological_processGO:0021904 dorsal/ventral neural tube patterning IEA
 biological_processGO:0021978 telencephalon regionalization IEA
 biological_processGO:0021983 pituitary gland development IEA
 biological_processGO:0030218 erythrocyte differentiation IEA
 biological_processGO:0030224 monocyte differentiation IDA
 biological_processGO:0030225 macrophage differentiation IDA
 biological_processGO:0030501 positive regulation of bone mineralization IDA
 biological_processGO:0030509 BMP signaling pathway IMP
 biological_processGO:0030513 positive regulation of BMP signaling pathway ISS
 biological_processGO:0032092 positive regulation of protein binding IDA
 biological_processGO:0032331 negative regulation of chondrocyte differentiation IEA
 biological_processGO:0032967 positive regulation of collagen biosynthetic process IDA
 biological_processGO:0033085 negative regulation of T cell differentiation in thymus IMP
 biological_processGO:0033088 negative regulation of immature T cell proliferation in thymus IMP
 biological_processGO:0034504 protein localization to nucleus IDA
 biological_processGO:0035116 embryonic hindlimb morphogenesis IEA
 biological_processGO:0035990 tendon cell differentiation ISS
 biological_processGO:0035993 deltoid tuberosity development ISS
 biological_processGO:0042306 regulation of protein import into nucleus IDA
 biological_processGO:0042326 negative regulation of phosphorylation IDA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0042476 odontogenesis IGI
 biological_processGO:0042487 regulation of odontogenesis of dentin-containing tooth IEA
 biological_processGO:0042733 embryonic digit morphogenesis IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IMP
 biological_processGO:0043407 negative regulation of MAP kinase activity IDA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0045603 positive regulation of endothelial cell differentiation IEA
 biological_processGO:0045606 positive regulation of epidermal cell differentiation IDA
 biological_processGO:0045662 negative regulation of myoblast differentiation IDA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IDA
 biological_processGO:0045778 positive regulation of ossification IDA
 biological_processGO:0045786 negative regulation of cell cycle IDA
 biological_processGO:0045839 negative regulation of mitotic nuclear division IDA
 biological_processGO:0045843 negative regulation of striated muscle tissue development IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0048286 lung alveolus development IDA
 biological_processGO:0048392 intermediate mesodermal cell differentiation IDA
 biological_processGO:0048468 cell development IBA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IDA
 biological_processGO:0048663 neuron fate commitment IEA
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IEA
 biological_processGO:0048745 smooth muscle tissue development ISS
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IDA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IDA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0051150 regulation of smooth muscle cell differentiation IEA
 biological_processGO:0055007 cardiac muscle cell differentiation IEA
 biological_processGO:0055020 positive regulation of cardiac muscle fiber development IMP
 biological_processGO:0060113 inner ear receptor cell differentiation IEA
 biological_processGO:0060197 cloacal septation IEA
 biological_processGO:0060235 lens induction in camera-type eye IEA
 biological_processGO:0060272 embryonic skeletal joint morphogenesis IEA
 biological_processGO:0060363 cranial suture morphogenesis IEA
 biological_processGO:0060391 positive regulation of SMAD protein signal transduction IDA
 biological_processGO:0060393 regulation of pathway-restricted SMAD protein phosphorylation IDA
 biological_processGO:0060395 SMAD protein signal transduction IDA
 biological_processGO:0060425 lung morphogenesis IDA
 biological_processGO:0060433 bronchus development IDA
 biological_processGO:0060438 trachea development IDA
 biological_processGO:0060440 trachea formation IEA
 biological_processGO:0060441 epithelial tube branching involved in lung morphogenesis IDA
 biological_processGO:0060442 branching involved in prostate gland morphogenesis IEA
 biological_processGO:0060449 bud elongation involved in lung branching IEA
 biological_processGO:0060502 epithelial cell proliferation involved in lung morphogenesis IDA
 biological_processGO:0060503 bud dilation involved in lung branching IDA
 biological_processGO:0060548 negative regulation of cell death IDA
 biological_processGO:0060592 mammary gland formation IEA
 biological_processGO:0060684 epithelial-mesenchymal cell signaling IEA
 biological_processGO:0060686 negative regulation of prostatic bud formation IEA
 biological_processGO:0060687 regulation of branching involved in prostate gland morphogenesis IEA
 biological_processGO:0060976 coronary vasculature development ISS
 biological_processGO:0061036 positive regulation of cartilage development IDA
 biological_processGO:0061047 positive regulation of branching involved in lung morphogenesis ISS
 biological_processGO:0061149 BMP signaling pathway involved in ureter morphogenesis ISS
 biological_processGO:0061151 BMP signaling pathway involved in renal system segmentation ISS
 biological_processGO:0061155 pulmonary artery endothelial tube morphogenesis IDA
 biological_processGO:0061312 BMP signaling pathway involved in heart development ISS
 biological_processGO:0061626 pharyngeal arch artery morphogenesis ISS
 biological_processGO:0070244 negative regulation of thymocyte apoptotic process IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071773 cellular response to BMP stimulus IMP
 biological_processGO:0071893 BMP signaling pathway involved in nephric duct formation IDA
 biological_processGO:0072001 renal system development IEP
 biological_processGO:0072015 glomerular visceral epithelial cell development IEA
 biological_processGO:0072097 negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway IDA
 biological_processGO:0072101 specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway IDA
 biological_processGO:0072104 glomerular capillary formation ISS
 biological_processGO:0072125 negative regulation of glomerular mesangial cell proliferation IDA
 biological_processGO:0072138 mesenchymal cell proliferation involved in ureteric bud development IEA
 biological_processGO:0072161 mesenchymal cell differentiation involved in kidney development IEA
 biological_processGO:0072192 ureter epithelial cell differentiation ISS
 biological_processGO:0072193 ureter smooth muscle cell differentiation ISS
 biological_processGO:0072198 mesenchymal cell proliferation involved in ureter development IEA
 biological_processGO:0072200 negative regulation of mesenchymal cell proliferation involved in ureter development IDA
 biological_processGO:0072205 metanephric collecting duct development ISS
 biological_processGO:0090184 positive regulation of kidney development IDA
 biological_processGO:0090191 negative regulation of branching involved in ureteric bud morphogenesis IDA
 biological_processGO:0090194 negative regulation of glomerulus development IDA
 biological_processGO:1901964 positive regulation of cell proliferation involved in outflow tract morphogenesis ISS
 biological_processGO:1902893 regulation of pri-miRNA transcription by RNA polymerase II IMP
 biological_processGO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II IDA
 biological_processGO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA IDA
 biological_processGO:1905072 cardiac jelly development ISS
 biological_processGO:1905312 positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis IEA
 biological_processGO:2000005 negative regulation of metanephric S-shaped body morphogenesis IDA
 biological_processGO:2000007 negative regulation of metanephric comma-shaped body morphogenesis IDA
 biological_processGO:2000137 negative regulation of cell proliferation involved in heart morphogenesis IMP
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway ISS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 molecular_functionGO:0005125 cytokine activity IDA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0039706 co-receptor binding IPI
 molecular_functionGO:0042056 chemoattractant activity IDA
 molecular_functionGO:0070700 BMP receptor binding IDA


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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