6622


Homo sapiens (NCBI)

Features
Gene ID: 6622
  
Biological name :
  
Synonyms : NACP|PARK1|PARK4|PD1 / SNCA / synuclein alpha
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 204466_s_at (Human Genome U133 Plus 2.0 Array)   204467_s_at (Human Genome U133 Plus 2.0 Array)   207827_x_at (Human Genome U133 Plus 2.0 Array)   211546_x_at (Human Genome U133 Plus 2.0 Array)   236081_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - XP_016864052.1
RefSeq - 1034640995
RefSeq - 225690602
RefSeq - 225690604
RefSeq - 4507109
RefSeq - 6806898
RefSeq - 767932529
RefSeq - 767932531
RefSeq - 767932533
RefSeq - 767932535
RefSeq - 767932537
RefSeq - 767932539
RefSeq - NC_000004.12
RefSeq - NG_011851.1
RefSeq - NP_000336.1
RefSeq - NP_001139526.1
RefSeq - NP_001139527.1
RefSeq - NP_009292.1
RefSeq - XP_011530505.1
RefSeq - XP_011530506.1
RefSeq - XP_011530507.1
RefSeq - XP_011530508.1
RefSeq - XP_011530509.1
RefSeq - XP_011530510.1
RefSeq - XP_016864051.1
RefSeq - 1034640993
RefSeq - NM_000345.3
RefSeq - NM_001146054.1
RefSeq - NM_001146055.1
RefSeq - NM_007308.2
RefSeq - XM_011532207.1
RefSeq - XM_011532208.2
RefSeq - XM_017008562.1
RefSeq - XM_017008563.1
RefSeq - XM_011532203.1
RefSeq - XM_011532204.3
RefSeq - XM_011532205.2
RefSeq - XM_011532206.1
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000145335 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II TAS
 biological_processGO:0001774 microglial cell activation TAS
 biological_processGO:0001921 positive regulation of receptor recycling IDA
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0001956 positive regulation of neurotransmitter secretion IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006638 neutral lipid metabolic process IEA
 biological_processGO:0006644 phospholipid metabolic process IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0007006 mitochondrial membrane organization IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008344 adult locomotory behavior IEA
 biological_processGO:0010040 response to iron(II) ion IDA
 biological_processGO:0010517 regulation of phospholipase activity IDA
 biological_processGO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway IDA
 biological_processGO:0014048 regulation of glutamate secretion IEA
 biological_processGO:0014059 regulation of dopamine secretion TAS
 biological_processGO:0022898 regulation of transmembrane transporter activity IGI
 biological_processGO:0031115 negative regulation of microtubule polymerization IDA
 biological_processGO:0031623 receptor internalization IDA
 biological_processGO:0031648 protein destabilization IDA
 biological_processGO:0032026 response to magnesium ion IDA
 biological_processGO:0032410 negative regulation of transporter activity IDA
 biological_processGO:0032496 response to lipopolysaccharide IDA
 biological_processGO:0032769 negative regulation of monooxygenase activity IDA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation ISS
 biological_processGO:0034341 response to interferon-gamma IDA
 biological_processGO:0034599 cellular response to oxidative stress IC
 biological_processGO:0035067 negative regulation of histone acetylation IDA
 biological_processGO:0040012 regulation of locomotion IEA
 biological_processGO:0042416 dopamine biosynthetic process TAS
 biological_processGO:0042775 mitochondrial ATP synthesis coupled electron transport IEA
 biological_processGO:0043030 regulation of macrophage activation IEA
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus IEA
 biological_processGO:0045807 positive regulation of endocytosis IDA
 biological_processGO:0045920 negative regulation of exocytosis IMP
 biological_processGO:0045963 negative regulation of dopamine metabolic process IEA
 biological_processGO:0048148 behavioral response to cocaine IEA
 biological_processGO:0048169 regulation of long-term neuronal synaptic plasticity IEA
 biological_processGO:0048488 synaptic vesicle endocytosis ISS
 biological_processGO:0048489 synaptic vesicle transport IEA
 biological_processGO:0050729 positive regulation of inflammatory response IDA
 biological_processGO:0050808 synapse organization IEA
 biological_processGO:0050812 regulation of acyl-CoA biosynthetic process IEA
 biological_processGO:0051281 positive regulation of release of sequestered calcium ion into cytosol IDA
 biological_processGO:0051583 dopamine uptake involved in synaptic transmission TAS
 biological_processGO:0051585 negative regulation of dopamine uptake involved in synaptic transmission IDA
 biological_processGO:0051612 negative regulation of serotonin uptake IDA
 biological_processGO:0051621 regulation of norepinephrine uptake IGI
 biological_processGO:0051622 negative regulation of norepinephrine uptake IDA
 biological_processGO:0055074 calcium ion homeostasis IDA
 biological_processGO:0055114 oxidation-reduction process IDA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0060291 long-term synaptic potentiation IEA
 biological_processGO:0060732 positive regulation of inositol phosphate biosynthetic process IDA
 biological_processGO:0070495 negative regulation of thrombin-activated receptor signaling pathway IDA
 biological_processGO:0070555 response to interleukin-1 IDA
 biological_processGO:0071280 cellular response to copper ion IDA
 biological_processGO:0071872 cellular response to epinephrine stimulus TAS
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IDA
 biological_processGO:0097435 supramolecular fiber organization TAS
 biological_processGO:1901215 negative regulation of neuron death IDA
 biological_processGO:1901216 positive regulation of neuron death IDA
 biological_processGO:1902957 negative regulation of mitochondrial electron transport, NADH to ubiquinone TAS
 biological_processGO:1903284 positive regulation of glutathione peroxidase activity IDA
 biological_processGO:1903285 positive regulation of hydrogen peroxide catabolic process IDA
 biological_processGO:1903421 regulation of synaptic vesicle recycling TAS
 biological_processGO:1903426 regulation of reactive oxygen species biosynthetic process TAS
 biological_processGO:1904307 response to desipramine IEA
 biological_processGO:1904715 negative regulation of chaperone-mediated autophagy IMP
 biological_processGO:1905606 regulation of presynapse assembly IGI
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005640 nuclear outer membrane IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion TAS
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005747 mitochondrial respiratory chain complex I TAS
 cellular_componentGO:0005758 mitochondrial intermembrane space IEA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0005764 lysosome TAS
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005840 ribosome IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005938 cell cortex IDA
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016234 inclusion body IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0030426 growth cone IDA
 cellular_componentGO:0031092 platelet alpha granule membrane IDA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0098794 postsynapse IEA
 cellular_componentGO:0099512 supramolecular fiber IDA
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0003779 actin binding IPI
 molecular_functionGO:0005504 fatty acid binding IDA
 molecular_functionGO:0005507 copper ion binding IDA
 molecular_functionGO:0005509 calcium ion binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005543 phospholipid binding IDA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0008198 ferrous iron binding IDA
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0016491 oxidoreductase activity IDA
 molecular_functionGO:0019894 kinesin binding IPI
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030544 Hsp70 protein binding IPI
 molecular_functionGO:0042393 histone binding IDA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0043014 alpha-tubulin binding IPI
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA
 molecular_functionGO:0043274 phospholipase binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding TAS
 molecular_functionGO:0047485 protein N-terminus binding IEA
 molecular_functionGO:0048156 tau protein binding IDA
 molecular_functionGO:0048487 beta-tubulin binding IEA
 molecular_functionGO:0051219 phosphoprotein binding IDA
 molecular_functionGO:0060961 phospholipase D inhibitor activity IDA
 molecular_functionGO:0070840 dynein complex binding IPI
 molecular_functionGO:1903136 cuprous ion binding IMP


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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