6774


Homo sapiens (NCBI)

Features
Gene ID: 6774
  
Biological name :
  
Synonyms : ADMIO|ADMIO1|APRF|HIES / signal transducer and activator of transcription 3 / STAT3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 208991_at (Human Genome U133 Plus 2.0 Array)   208992_s_at (Human Genome U133 Plus 2.0 Array)   225289_at (Human Genome U133 Plus 2.0 Array)   243213_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 767995662
RefSeq - 1034600939
RefSeq - 1034600941
RefSeq - 1034600943
RefSeq - 1034600945
RefSeq - 1370471998
RefSeq - 21618338
RefSeq - 21618340
RefSeq - 47458820
RefSeq - 767995660
RefSeq - 1034600937
RefSeq - 767995664
RefSeq - 767995666
RefSeq - NC_000017.11
RefSeq - NG_007370.1
RefSeq - NP_003141.2
RefSeq - NP_644805.1
RefSeq - NP_998827.1
RefSeq - XP_005257673.2
RefSeq - XP_005257674.2
RefSeq - XP_011523447.1
RefSeq - XP_011523448.1
RefSeq - XP_016880461.1
RefSeq - XP_016880462.1
RefSeq - XP_016880463.1
RefSeq - XP_016880464.1
RefSeq - XP_016880465.1
RefSeq - XP_024306664.1
RefSeq - NM_003150.3
RefSeq - NM_139276.2
RefSeq - NM_213662.1
RefSeq - XM_017024975.1
RefSeq - XM_017024976.1
RefSeq - XM_024450896.1
RefSeq - XM_005257616.4
RefSeq - XM_005257617.3
RefSeq - XM_011525145.3
RefSeq - XM_011525146.3
RefSeq - XM_017024972.1
RefSeq - XM_017024973.2
RefSeq - XM_017024974.1
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000168610 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II TAS
 biological_processGO:0001659 temperature homeostasis ISS
 biological_processGO:0001754 eye photoreceptor cell differentiation ISS
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II ISS
 biological_processGO:0006606 protein import into nucleus IDA
 biological_processGO:0006953 acute-phase response IEA
 biological_processGO:0006954 inflammatory response ISS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007259 JAK-STAT cascade TAS
 biological_processGO:0007399 nervous system development TAS
 biological_processGO:0007568 aging IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010730 negative regulation of hydrogen peroxide biosynthetic process IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016310 phosphorylation ISS
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0019953 sexual reproduction ISS
 biological_processGO:0030522 intracellular receptor signaling pathway IDA
 biological_processGO:0032355 response to estradiol IDA
 biological_processGO:0032870 cellular response to hormone stimulus IDA
 biological_processGO:0033210 leptin-mediated signaling pathway IDA
 biological_processGO:0035019 somatic stem cell population maintenance TAS
 biological_processGO:0035278 miRNA mediated inhibition of translation IDA
 biological_processGO:0035723 interleukin-15-mediated signaling pathway TAS
 biological_processGO:0038111 interleukin-7-mediated signaling pathway TAS
 biological_processGO:0038114 interleukin-21-mediated signaling pathway TAS
 biological_processGO:0038155 interleukin-23-mediated signaling pathway TAS
 biological_processGO:0040014 regulation of multicellular organism growth IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein TAS
 biological_processGO:0042593 glucose homeostasis ISS
 biological_processGO:0042755 eating behavior ISS
 biological_processGO:0042789 mRNA transcription by RNA polymerase II IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0044320 cellular response to leptin stimulus IDA
 biological_processGO:0044321 response to leptin IDA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IMP
 biological_processGO:0045747 positive regulation of Notch signaling pathway ISS
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045820 negative regulation of glycolytic process IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0046902 regulation of mitochondrial membrane permeability IEA
 biological_processGO:0048708 astrocyte differentiation ISS
 biological_processGO:0051726 regulation of cell cycle IDA
 biological_processGO:0060019 radial glial cell differentiation ISS
 biological_processGO:0060259 regulation of feeding behavior ISS
 biological_processGO:0060396 growth hormone receptor signaling pathway IDA
 biological_processGO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway ISS
 biological_processGO:0070102 interleukin-6-mediated signaling pathway TAS
 biological_processGO:0070106 interleukin-27-mediated signaling pathway TAS
 biological_processGO:0070757 interleukin-35-mediated signaling pathway TAS
 biological_processGO:0071345 cellular response to cytokine stimulus TAS
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0072540 T-helper 17 cell lineage commitment ISS
 biological_processGO:0097009 energy homeostasis ISS
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1902728 positive regulation of growth factor dependent skeletal muscle satellite cell proliferation IEA
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IDA
 biological_processGO:1904685 positive regulation of metalloendopeptidase activity IGI
 biological_processGO:1905564 positive regulation of vascular endothelial cell proliferation IEA
 biological_processGO:2000637 positive regulation of gene silencing by miRNA IDA
 biological_processGO:2000737 negative regulation of stem cell differentiation IEA
 biological_processGO:2001171 positive regulation of ATP biosynthetic process IEA
 biological_processGO:2001223 negative regulation of neuron migration IEA
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IMP
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0001103 RNA polymerase II repressing transcription factor binding IPI
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding ISS
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0004879 nuclear receptor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0019901 protein kinase binding ISS
 molecular_functionGO:0019903 protein phosphatase binding IPI
 molecular_functionGO:0031490 chromatin DNA binding IDA
 molecular_functionGO:0031730 CCR5 chemokine receptor binding IEA
 molecular_functionGO:0035259 glucocorticoid receptor binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046983 protein dimerization activity ISS


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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