7040


Homo sapiens (NCBI)

Features
Gene ID: 7040
  
Biological name :
  
Synonyms : CED|DPD1|LAP|TGFB|TGFbeta / TGFB1 / transforming growth factor beta 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 203084_at (Human Genome U133 Plus 2.0 Array)   203085_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 63025222
RefSeq - 768010712
RefSeq - NC_000019.10
RefSeq - NG_013364.1
RefSeq - NP_000651.3
RefSeq - XP_011525544.1
RefSeq - NM_000660.6
RefSeq - XM_011527242.2
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000105329 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000060 protein import into nucleus, translocation IDA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000165 MAPK cascade IMP
 biological_processGO:0001570 vasculogenesis ISS
 biological_processGO:0001657 ureteric bud development IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001837 epithelial to mesenchymal transition IDA
 biological_processGO:0001843 neural tube closure ISS
 biological_processGO:0001933 negative regulation of protein phosphorylation IDA
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0002028 regulation of sodium ion transport IEA
 biological_processGO:0002062 chondrocyte differentiation IDA
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IDA
 biological_processGO:0002248 connective tissue replacement involved in inflammatory response wound healing TAS
 biological_processGO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains IEA
 biological_processGO:0002513 tolerance induction to self antigen IEA
 biological_processGO:0002576 platelet degranulation TAS
 biological_processGO:0003179 heart valve morphogenesis ISS
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0006611 protein export from nucleus IDA
 biological_processGO:0006754 ATP biosynthetic process IDA
 biological_processGO:0006796 phosphate-containing compound metabolic process IDA
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0006954 inflammatory response IDA
 biological_processGO:0007050 cell cycle arrest IDA
 biological_processGO:0007093 mitotic cell cycle checkpoint IDA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IDA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway TAS
 biological_processGO:0007182 common-partner SMAD protein phosphorylation IDA
 biological_processGO:0007183 SMAD protein complex assembly IDA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007406 negative regulation of neuroblast proliferation IEA
 biological_processGO:0007435 salivary gland morphogenesis IEP
 biological_processGO:0007492 endoderm development IEA
 biological_processGO:0007507 heart development ISS
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0008354 germ cell migration IEA
 biological_processGO:0009611 response to wounding IEP
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0009817 defense response to fungus, incompatible interaction IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production TAS
 biological_processGO:0010628 positive regulation of gene expression ISS
 biological_processGO:0010629 negative regulation of gene expression ISS
 biological_processGO:0010716 negative regulation of extracellular matrix disassembly IC
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition NAS
 biological_processGO:0010742 macrophage derived foam cell differentiation IC
 biological_processGO:0010763 positive regulation of fibroblast migration IDA
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IDA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IDA
 biological_processGO:0010936 negative regulation of macrophage cytokine production IDA
 biological_processGO:0014003 oligodendrocyte development IEA
 biological_processGO:0016202 regulation of striated muscle tissue development ISS
 biological_processGO:0016477 cell migration IDA
 biological_processGO:0017015 regulation of transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0019049 evasion or tolerance of host defenses by virus IDA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0021915 neural tube development ISS
 biological_processGO:0022408 negative regulation of cell-cell adhesion IDA
 biological_processGO:0030214 hyaluronan catabolic process IDA
 biological_processGO:0030279 negative regulation of ossification IEA
 biological_processGO:0030308 negative regulation of cell growth IDA
 biological_processGO:0030316 osteoclast differentiation IEA
 biological_processGO:0030334 regulation of cell migration TAS
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0030501 positive regulation of bone mineralization IEP
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway TAS
 biological_processGO:0031065 positive regulation of histone deacetylation IEA
 biological_processGO:0031293 membrane protein intracellular domain proteolysis IDA
 biological_processGO:0031334 positive regulation of protein complex assembly IDA
 biological_processGO:0031536 positive regulation of exit from mitosis IEA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IDA
 biological_processGO:0032270 positive regulation of cellular protein metabolic process IDA
 biological_processGO:0032355 response to estradiol IDA
 biological_processGO:0032570 response to progesterone IDA
 biological_processGO:0032667 regulation of interleukin-23 production IEA
 biological_processGO:0032700 negative regulation of interleukin-17 production IEA
 biological_processGO:0032740 positive regulation of interleukin-17 production IDA
 biological_processGO:0032801 receptor catabolic process IDA
 biological_processGO:0032930 positive regulation of superoxide anion generation IDA
 biological_processGO:0032943 mononuclear cell proliferation IEA
 biological_processGO:0032967 positive regulation of collagen biosynthetic process IMP
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IDA
 biological_processGO:0033280 response to vitamin D IEA
 biological_processGO:0034616 response to laminar fluid shear stress IEA
 biological_processGO:0035066 positive regulation of histone acetylation IEA
 biological_processGO:0035307 positive regulation of protein dephosphorylation IDA
 biological_processGO:0035902 response to immobilization stress IEA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042130 negative regulation of T cell proliferation IEA
 biological_processGO:0042306 regulation of protein import into nucleus ISS
 biological_processGO:0042307 positive regulation of protein import into nucleus IDA
 biological_processGO:0042482 positive regulation of odontogenesis IEA
 biological_processGO:0042552 myelination IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043011 myeloid dendritic cell differentiation IEA
 biological_processGO:0043029 T cell homeostasis IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043117 positive regulation of vascular permeability IDA
 biological_processGO:0043406 positive regulation of MAP kinase activity IDA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0043491 protein kinase B signaling IMP
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IDA
 biological_processGO:0043537 negative regulation of blood vessel endothelial cell migration IDA
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IDA
 biological_processGO:0043932 ossification involved in bone remodeling IEP
 biological_processGO:0045066 regulatory T cell differentiation IEA
 biological_processGO:0045216 cell-cell junction organization IDA
 biological_processGO:0045591 positive regulation of regulatory T cell differentiation IEA
 biological_processGO:0045596 negative regulation of cell differentiation IEP
 biological_processGO:0045599 negative regulation of fat cell differentiation IDA
 biological_processGO:0045662 negative regulation of myoblast differentiation IDA
 biological_processGO:0045786 negative regulation of cell cycle IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045930 negative regulation of mitotic cell cycle IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0048298 positive regulation of isotype switching to IgA isotypes IDA
 biological_processGO:0048468 cell development IBA
 biological_processGO:0048535 lymph node development ISS
 biological_processGO:0048565 digestive tract development IEA
 biological_processGO:0048642 negative regulation of skeletal muscle tissue development IDA
 biological_processGO:0048839 inner ear development IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IMP
 biological_processGO:0050714 positive regulation of protein secretion IDA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050765 negative regulation of phagocytosis IEA
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0050921 positive regulation of chemotaxis IDA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051098 regulation of binding ISS
 biological_processGO:0051101 regulation of DNA binding ISS
 biological_processGO:0051152 positive regulation of smooth muscle cell differentiation IEA
 biological_processGO:0051280 negative regulation of release of sequestered calcium ion into cytosol IEA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IDA
 biological_processGO:0055010 ventricular cardiac muscle tissue morphogenesis ISS
 biological_processGO:0060312 regulation of blood vessel remodeling NAS
 biological_processGO:0060325 face morphogenesis IEA
 biological_processGO:0060364 frontal suture morphogenesis IEA
 biological_processGO:0060389 pathway-restricted SMAD protein phosphorylation IDA
 biological_processGO:0060390 regulation of SMAD protein signal transduction IDA
 biological_processGO:0060391 positive regulation of SMAD protein signal transduction IDA
 biological_processGO:0060395 SMAD protein signal transduction IBA
 biological_processGO:0060744 mammary gland branching involved in thelarche IEA
 biological_processGO:0060751 branch elongation involved in mammary gland duct branching IEA
 biological_processGO:0060762 regulation of branching involved in mammary gland duct morphogenesis IEA
 biological_processGO:0060965 negative regulation of gene silencing by miRNA IGI
 biological_processGO:0061035 regulation of cartilage development IEA
 biological_processGO:0070168 negative regulation of biomineral tissue development IDA
 biological_processGO:0070306 lens fiber cell differentiation IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0070723 response to cholesterol IDA
 biological_processGO:0071158 positive regulation of cell cycle arrest IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IDA
 biological_processGO:0071479 cellular response to ionizing radiation IEA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IGI
 biological_processGO:0071677 positive regulation of mononuclear cell migration IEA
 biological_processGO:0085029 extracellular matrix assembly IDA
 biological_processGO:0090190 positive regulation of branching involved in ureteric bud morphogenesis IEA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IDA
 biological_processGO:0097421 liver regeneration IEA
 biological_processGO:1900126 negative regulation of hyaluronan biosynthetic process IDA
 biological_processGO:1900182 positive regulation of protein localization to nucleus IDA
 biological_processGO:1901203 positive regulation of extracellular matrix assembly IC
 biological_processGO:1901666 positive regulation of NAD+ ADP-ribosyltransferase activity IDA
 biological_processGO:1902074 response to salt IEA
 biological_processGO:1902893 regulation of pri-miRNA transcription by RNA polymerase II IMP
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IDA
 biological_processGO:1903077 negative regulation of protein localization to plasma membrane IDA
 biological_processGO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA IGI
 biological_processGO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA IDA
 biological_processGO:1903911 positive regulation of receptor clustering IEA
 biological_processGO:1905005 regulation of epithelial to mesenchymal transition involved in endocardial cushion formation ISS
 biological_processGO:1905313 transforming growth factor beta receptor signaling pathway involved in heart development ISS
 biological_processGO:1990314 cellular response to insulin-like growth factor stimulus IEA
 biological_processGO:1990402 embryonic liver development ISS
 biological_processGO:2000249 regulation of actin cytoskeleton reorganization IEA
 biological_processGO:2000679 positive regulation of transcription regulatory region DNA binding IDA
 biological_processGO:2000727 positive regulation of cardiac muscle cell differentiation IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005902 microvillus IDA
 cellular_componentGO:0009986 cell surface IMP
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0031012 extracellular matrix ISS
 cellular_componentGO:0031093 platelet alpha granule lumen TAS
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0062023 collagen-containing extracellular matrix HDA
 cellular_componentGO:0072562 blood microparticle HDA
 molecular_functionGO:0003823 antigen binding IPI
 molecular_functionGO:0005114 type II transforming growth factor beta receptor binding IPI
 molecular_functionGO:0005125 cytokine activity TAS
 molecular_functionGO:0005160 transforming growth factor beta receptor binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0034713 type I transforming growth factor beta receptor binding IPI
 molecular_functionGO:0034714 type III transforming growth factor beta receptor binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043539 protein serine/threonine kinase activator activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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