9451


Homo sapiens (NCBI)

Features
Gene ID: 9451
  
Biological name :
  
Synonyms : EIF2AK3 / eukaryotic translation initiation factor 2 alpha kinase 3 / PEK|PERK|WRS
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 218696_at (Human Genome U133 Plus 2.0 Array)   241463_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 1034617993
RefSeq - 134304838
RefSeq - 927028872
RefSeq - NC_000002.12
RefSeq - NG_016424.1
RefSeq - NP_001300844.1
RefSeq - NP_004827.4
RefSeq - XP_016860865.1
RefSeq - NM_001313915.1
RefSeq - NM_004836.6
RefSeq - XM_017005376.2
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000172071 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development ISS
 biological_processGO:0001503 ossification IMP
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0002063 chondrocyte development ISS
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process ISS
 biological_processGO:0006983 ER overload response IDA
 biological_processGO:0007029 endoplasmic reticulum organization ISS
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation ISS
 biological_processGO:0017148 negative regulation of translation TAS
 biological_processGO:0018105 peptidyl-serine phosphorylation ISS
 biological_processGO:0019722 calcium-mediated signaling ISS
 biological_processGO:0030282 bone mineralization ISS
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response TAS
 biological_processGO:0031018 endocrine pancreas development IMP
 biological_processGO:0031642 negative regulation of myelination ISS
 biological_processGO:0032057 negative regulation of translational initiation in response to stress TAS
 biological_processGO:0034198 cellular response to amino acid starvation IMP
 biological_processGO:0034976 response to endoplasmic reticulum stress IMP
 biological_processGO:0036492 eiF2alpha phosphorylation in response to endoplasmic reticulum stress TAS
 biological_processGO:0036499 PERK-mediated unfolded protein response TAS
 biological_processGO:0042149 cellular response to glucose starvation IMP
 biological_processGO:0045943 positive regulation of transcription by RNA polymerase I IMP
 biological_processGO:0046777 protein autophosphorylation IMP
 biological_processGO:0048009 insulin-like growth factor receptor signaling pathway ISS
 biological_processGO:0051260 protein homooligomerization IMP
 biological_processGO:0060734 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation ISS
 biological_processGO:0070417 cellular response to cold IMP
 biological_processGO:1900182 positive regulation of protein localization to nucleus ISS
 biological_processGO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
 biological_processGO:1990737 response to manganese-induced endoplasmic reticulum stress IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005783 endoplasmic reticulum TAS
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0022626 cytosolic ribosome IBA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane NAS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004672 protein kinase activity TAS
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004694 eukaryotic translation initiation factor 2alpha kinase activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019903 protein phosphatase binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity TAS
 molecular_functionGO:0051879 Hsp90 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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