ENSDARG00000001803


Danio rerio

Features
Gene ID: ENSDARG00000001803
  
Biological name :kcnh6a
  
Synonyms : kcnh6a / potassium voltage-gated channel, subfamily H (eag-related), member 6a
  
Possible biological names infered from orthology : KCNH6 / KCNH7 / potassium voltage-gated channel, subfamily H (eag-related), member 6 / potassium voltage-gated channel subfamily H member 6 / potassium voltage-gated channel subfamily H member 7 / Q9ER47 / Q9H252 / Q9NS40
  
Species: Danio rerio
  
Chr. number: 3
Strand: -1
Band:
Gene start: 31728871
Gene end: 31784082
  
Corresponding Affymetrix probe sets: DrAffx.1.5.S1_at (Zebrafish Array)   NM_212837_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000085242
Ensembl peptide - ENSDARP00000122913
NCBI entrez gene - 405763     See in Manteia.
RefSeq - NM_212837
RefSeq - XM_005164007
RefSeq Peptide - NP_998002
swissprot - F6NT38
swissprot - B3DJX4
swissprot - E9QJ94
ZFIN ID - ZDB-GENE-040702-5
Ensembl - ENSDARG00000001803
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000035938Gallus gallus
 ENSGALG00000038543Gallus gallus
 KCNH6ENSGALG00000000505Gallus gallus
 KCNH6ENSG00000173826Homo sapiens
 KCNH7ENSG00000184611Homo sapiens
 Kcnh6ENSMUSG00000001901Mus musculus
 Kcnh7ENSMUSG00000059742Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
kcnh2a / potassium voltage-gated channel, subfamily H (eag-related), member 2a / KCNH2* / Q12809* / potassium voltage-gated channel subfamily H member 2*ENSDARG0000002988155
kcnh7 / potassium channel, voltage gated eag related subfamily H, member 7ENSDARG0000006268754
CABZ01076968.1 / KCNH2* / Q12809* / potassium voltage-gated channel subfamily H member 2*ENSDARG0000010647337
kcnh6b / potassium voltage-gated channel, subfamily H (eag-related), member 6b / KCNH6* / KCNH7* / Q9NS40* / Q9ER47* / Q9H252* / potassium voltage-gated channel subfamily H member 6* / pota...ENSDARG0000001029637
kcnh8 / potassium voltage-gated channel, subfamily H (eag-related), member 8 / Q96L42* / potassium voltage-gated channel subfamily H member 8*ENSDARG0000006264028
kcnh3 / potassium voltage-gated channel, subfamily H (eag-related), member 3 / Q9ULD8* / Q9WVJ0* / potassium voltage-gated channel subfamily H member 3*ENSDARG0000006956027
kcnh5a / potassium voltage-gated channel, subfamily H (eag-related), member 5a / KCNH5* / Q8NCM2* / Q920E3* / potassium voltage-gated channel subfamily H member 5*ENSDARG0000004322027
kcnh4a / potassium voltage-gated channel, subfamily H (eag-related), member 4a / KCNH4* / Q9UQ05* / potassium voltage-gated channel subfamily H member 4*ENSDARG0000006256527
kcnh4b / potassium voltage-gated channel, subfamily H (eag-related), member 4b / KCNH4* / Q9UQ05* / potassium voltage-gated channel subfamily H member 4*ENSDARG0000006199027
kcnh5b / potassium voltage-gated channel, subfamily H (eag-related), member 5bENSDARG0000006911726
kcnh1a / potassium voltage-gated channel, subfamily H (eag-related), member 1a / KCNH1* / O95259* / AC092017.3* / AL590132.1* / potassium voltage-gated channel subfamily H member 1*ENSDARG0000002416726
kcnh1a / kcnh1b / potassium voltage-gated channel, subfamily H (eag-related), member 1a / KCNH1* / O95259* / AC092017.3* / AL590132.1* / potassium voltage-gated channel subfamily H member 1*ENSDARG0000002323626
cngk / cyclic nucleotide-gated potassium channelENSDARG0000009326716


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR000595  Cyclic nucleotide-binding domain
 IPR003938  Potassium channel, voltage-dependent, EAG/ELK/ERG
 IPR003967  Potassium channel, voltage-dependent, ERG
 IPR005821  Ion transport domain
 IPR014710  RmlC-like jelly roll fold
 IPR018490  Cyclic nucleotide-binding-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0008016 regulation of heart contraction IMP
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060047 heart contraction IMP
 biological_processGO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization IMP
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 biological_processGO:0086013 membrane repolarization during cardiac muscle cell action potential IMP
 biological_processGO:0086091 regulation of heart rate by cardiac conduction IBA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISS
 molecular_functionGO:0005216 ion channel activity IMP
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005249 voltage-gated potassium channel activity IDA
 molecular_functionGO:0005267 potassium channel activity ISS


Pathways (from Reactome)
Pathway description
Voltage gated Potassium channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood nucleate erythrocyte increased amount , abnormal
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 ZFA:0000009 cardiac ventricle cardiac ventricle action potential , abnormal
cardiac ventricle non-functional , abnormal
cardiac ventricle non-contractile , abnormal
cardiac ventricle conductivity , abnormal
cardiac ventricle functionality , abnormal
cardiac ventricle contractility , abnormal
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 ZFA:0000014 dorsal aorta dorsal aorta decreased diameter , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000114 heart heart quality , abnormal
heart contractility , abnormal
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 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
whole organism decreased length , abnormal
whole organism semi-viable , abnormal
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 ZFA:0001315 atrioventricular canal atrioventricular canal functionality , abnormal
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 ZFA:0001439 anatomical system anatomical system quality , abnormal
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 ZFA:0005033 vertebral artery vertebral artery present , abnormal
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 ZFA:0005034 parachordal vessel parachordal vessel present , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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