ENSDARG00000003399


Danio rerio

Features
Gene ID: ENSDARG00000003399
  
Biological name :fgf8a
  
Synonyms : fgf8a / fibroblast growth factor 8a / O57341
  
Possible biological names infered from orthology :
  
Species: Danio rerio
  
Chr. number: 13
Strand: 1
Band:
Gene start: 28495419
Gene end: 28501985
  
Corresponding Affymetrix probe sets: Dr.478.1.S1_at (Zebrafish Array)   NM_131281_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000119341
Ensembl peptide - ENSDARP00000018653
NCBI entrez gene - 30538     See in Manteia.
RefSeq - NM_131281
RefSeq Peptide - NP_571356
swissprot - A2CF52
swissprot - O57341
ZFIN ID - ZDB-GENE-990415-72
Ensembl - ENSDARG00000003399
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
fgf8b / Q805B2 / fibroblast growth factor 8 bENSDARG0000003961570
fgf17 / Q6SJP8 / fibroblast growth factor 17 / O60258* / P63075*ENSDARG0000010277854
fgf24 / fibroblast growth factor 24ENSDARG0000003767745
fgf18b / fibroblast growth factor 18b / FGF18* / O89101* / O76093* / fibroblast growth factor 18*ENSDARG0000004396243
fgf18a / fibroblast growth factor 18a / FGF18* / O89101* / O76093* / fibroblast growth factor 18*ENSDARG0000008804843


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF
 IPR028249  Fibroblast growth factor 8


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001708 cell fate specification IMP
 biological_processGO:0001756 somitogenesis IGI
 biological_processGO:0003007 heart morphogenesis IMP
 biological_processGO:0003208 cardiac ventricle morphogenesis IMP
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0007420 brain development IMP
 biological_processGO:0007422 peripheral nervous system development IGI
 biological_processGO:0007492 endoderm development IMP
 biological_processGO:0007498 mesoderm development IGI
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0009880 embryonic pattern specification IGI
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0010002 cardioblast differentiation IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0014709 positive regulation of somitomeric trunk muscle development IMP
 biological_processGO:0021549 cerebellum development IMP
 biological_processGO:0021555 midbrain-hindbrain boundary morphogenesis IGI
 biological_processGO:0021571 rhombomere 5 development IGI
 biological_processGO:0021572 rhombomere 6 development IGI
 biological_processGO:0021588 cerebellum formation IMP
 biological_processGO:0021703 locus ceruleus development IMP
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IGI
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0030335 positive regulation of cell migration IGI
 biological_processGO:0030878 thyroid gland development IMP
 biological_processGO:0030901 midbrain development IMP
 biological_processGO:0030902 hindbrain development IMP
 biological_processGO:0030903 notochord development IGI
 biological_processGO:0030916 otic vesicle formation IMP
 biological_processGO:0030917 midbrain-hindbrain boundary development IMP
 biological_processGO:0031076 embryonic camera-type eye development IMP
 biological_processGO:0035050 embryonic heart tube development IGI
 biological_processGO:0042664 negative regulation of endodermal cell fate specification IGI
 biological_processGO:0043049 otic placode formation IMP
 biological_processGO:0046850 regulation of bone remodeling IMP
 biological_processGO:0048263 determination of dorsal identity IDA
 biological_processGO:0048339 paraxial mesoderm development IGI
 biological_processGO:0048665 neuron fate specification IGI
 biological_processGO:0048702 embryonic neurocranium morphogenesis IGI
 biological_processGO:0048705 skeletal system morphogenesis IMP
 biological_processGO:0048709 oligodendrocyte differentiation IGI
 biological_processGO:0048839 inner ear development IMP
 biological_processGO:0051146 striated muscle cell differentiation IMP
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0055012 ventricular cardiac muscle cell differentiation IMP
 biological_processGO:0060037 pharyngeal system development IGI
 biological_processGO:0060041 retina development in camera-type eye IGI
 biological_processGO:0060059 embryonic retina morphogenesis in camera-type eye IGI
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:0060788 ectodermal placode formation IMP
 biological_processGO:0061053 somite development IMP
 biological_processGO:0061195 taste bud formation IMP
 biological_processGO:0070121 Kupffer"s vesicle development IMP
 biological_processGO:0071599 otic vesicle development IGI
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005764 lysosome IDA
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle cilium decreased length , abnormal
Kupffers vesicle motile cilium shortened , abnormal
Kupffers vesicle cilium decreased amount , abnormal
Show

 ZFA:0000008 brain brain apoptotic , abnormal
brain quality , abnormal
Show

 ZFA:0000009 cardiac ventricle cardiac ventricle decreased length , abnormal
cardiac ventricle hypotrophic , abnormal
cardiac ventricle cardiac muscle cell decreased amount , abnormal
Show

 ZFA:0000016 ectoderm ectoderm morphology , abnormal
Show

 ZFA:0000023 forerunner cell group forerunner cell group distributed , abnormal
Show

 ZFA:0000029 hindbrain hindbrain blood vessel absent , abnormal
hindbrain apoptotic , abnormal
hindbrain decreased amount , abnormal
Show

 ZFA:0000035 lens lens apoptotic , abnormal
lens morphology , abnormal
Show

 ZFA:0000041 mesoderm mesoderm anterior region absent , abnormal
Show

 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary absent , abnormal
midbrain hindbrain boundary blood vessel absent , abnormal
midbrain hindbrain boundary quality , abnormal
midbrain hindbrain boundary morphology , abnormal
midbrain hindbrain boundary aplastic , abnormal
midbrain hindbrain boundary physical object quality , abnormal
midbrain hindbrain boundary decreased size , abnormal
Show

 ZFA:0000050 optic vesicle optic vesicle malformed , abnormal
Show

 ZFA:0000051 otic vesicle otic vesicle lacks all parts of type otolith , abnormal
otic vesicle lacks all parts of type hair cell , abnormal
otic vesicle decreased size , abnormal
otic vesicle has fewer parts of type otolith , abnormal
otic vesicle malformed , abnormal
otic vesicle agenesis , abnormal
otic vesicle morphology , abnormal
otic vesicle aplastic , abnormal
otic vesicle increased size , abnormal
otic vesicle mislocalised medially , abnormal
otic vesicle decreased amount , abnormal
Show

 ZFA:0000095 pharyngeal arch 3-7 skeleton pharyngeal arch 3-7 skeleton quality , abnormal
pharyngeal arch 3-7 skeleton disorganized , abnormal
pharyngeal arch 3-7 skeleton aplastic , abnormal
Show

 ZFA:0000099 brain vasculature brain vasculature dorsal region absent , abnormal
Show

 ZFA:0000100 cerebellum cerebellum morphology , abnormal
cerebellum aplastic , abnormal
cerebellum absent , abnormal
Show

 ZFA:0000101 diencephalon diencephalon dopaminergic neuron decreased amount , abnormal
Show

 ZFA:0000107 eye eye decreased amount , abnormal
Show

 ZFA:0000109 forebrain forebrain decreased amount , abnormal
Show

 ZFA:0000114 heart heart morphology , abnormal
heart decreased length , abnormal
heart dysplastic , abnormal
heart decreased size , abnormal
heart shape , abnormal
Show

 ZFA:0000115 heart rudiment heart rudiment decreased size , abnormal
Show

 ZFA:0000123 liver liver mislocalised , abnormal
Show

 ZFA:0000128 midbrain midbrain quality , abnormal
midbrain morphology , abnormal
midbrain mislocalised , abnormal
midbrain posterior side increased distribution , abnormal
midbrain posterior region absent , abnormal
midbrain posterior region mislocalised , abnormal
Show

 ZFA:0000138 otic placode otic placode physical object quality , abnormal
otic placode decreased size , abnormal
otic placode malformed , abnormal
otic placode mislocalised medially , abnormal
otic placode decreased amount , abnormal
Show

 ZFA:0000140 pancreas pancreas mislocalised , abnormal
Show

 ZFA:0000152 retina retina apoptotic , abnormal
retina morphology , abnormal
Show

 ZFA:0000155 somite somite poorly differentiated , abnormal
somite anterior-posterior axis condensed , abnormal
somite medial-lateral axis increased width , abnormal
Show

 ZFA:0000160 tegmentum tegmentum morphology , abnormal
Show

 ZFA:0000197 dorsal habenular nucleus dorsal habenular nucleus poorly differentiated , abnormal
Show

 ZFA:0000217 inner ear inner ear quality , abnormal
inner ear decreased size , abnormal
inner ear has fewer parts of type otolith , abnormal
Show

 ZFA:0000250 opercle opercle malformed , abnormal
opercle bilateral symmetry , abnormal
Show

 ZFA:0000255 paraxial mesoderm paraxial mesoderm mislocalised medially , abnormal
Show

 ZFA:0000279 segmental plate segmental plate decreased size , abnormal
Show

 ZFA:0000282 sensory system sensory system quality , abnormal
Show

 ZFA:0000396 nervous system nervous system quality , abnormal
Show

 ZFA:0000423 anterior cardinal vein anterior cardinal vein absent , abnormal
Show

 ZFA:0000431 semicircular canal semicircular canal truncated , abnormal
Show

 ZFA:0000445 optic tectum optic tectum blood vessel absent , abnormal
optic tectum increased size , abnormal
optic tectum apoptotic , abnormal
optic tectum physical object quality , abnormal
Show

 ZFA:0000471 atrium atrium cardiac muscle cell decreased amount , abnormal
Show

 ZFA:0000539 locus coeruleus locus coeruleus morphology , abnormal
locus coeruleus neuron decreased amount , abnormal
locus coeruleus aplastic , abnormal
locus coeruleus absent , abnormal
Show

 ZFA:0000558 posterior macula posterior macula decreased size , abnormal
posterior macula has fewer parts of type hair cell , abnormal
Show

 ZFA:0000559 otolith organ otolith organ has fewer parts of type otolith , abnormal
Show

 ZFA:0000816 oral epithelium oral epithelium has fewer parts of type taste bud , abnormal
Show

 ZFA:0000823 rhombomere 5 rhombomere 5 decreased thickness , abnormal
Show

 ZFA:0000948 rhombomere 3 rhombomere 3 decreased thickness , abnormal
Show

 ZFA:0001031 rhombomere 1 rhombomere 1 morphology , abnormal
Show

 ZFA:0001081 thyroid primordium thyroid primordium decreased size , abnormal
Show

 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
whole organism lacks all parts of type midbrain hindbrain boundary , abnormal
whole organism lacks all parts of type cerebellum , abnormal
Show

 ZFA:0001106 pharyngeal pouch pharyngeal pouch decreased amount , abnormal
pharyngeal pouch epithelial cell migration process quality , abnormal
pharyngeal pouch pharyngeal system development process quality , abnormal
pharyngeal pouch malformed , abnormal
Show

 ZFA:0001117 post-vent region post-vent region mesoderm morphology , abnormal
post-vent region curved ventral , abnormal
post-vent region truncated , abnormal
post-vent region mesoderm aplastic , abnormal
post-vent region mesoderm decreased amount , abnormal
Show

 ZFA:0001202 optic cup optic cup physical object quality , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton decreased size , abnormal
mandibular arch skeleton malformed , abnormal
Show

 ZFA:0001261 ventricular system ventricular system morphology , abnormal
Show

 ZFA:0001273 ventral mandibular arch ventral mandibular arch malformed , abnormal
ventral mandibular arch bilateral symmetry , abnormal
Show

 ZFA:0001276 pharyngeal arch 2 skeleton pharyngeal arch 2 skeleton decreased size , abnormal
pharyngeal arch 2 skeleton malformed , abnormal
Show

 ZFA:0001285 intersegmental vessel intersegmental vessel absent , abnormal
Show

 ZFA:0001294 epibranchial placode epibranchial placode morphology , abnormal
Show

 ZFA:0001306 pharyngeal arch pharyngeal arch blood vessel absent , abnormal
pharyngeal arch morphology , abnormal
Show

 ZFA:0001357 alar plate midbrain region alar plate midbrain region morphology , abnormal
Show

 ZFA:0001359 pineal complex pineal complex has extra parts of type photoreceptor cell , abnormal
Show

 ZFA:0001360 parapineal organ parapineal organ has fewer parts of type cell , abnormal
parapineal organ malformed , abnormal
Show

 ZFA:0001423 parachordal cartilage parachordal cartilage absent , abnormal
Show

 ZFA:0001424 chondrocranium chondrocranium bilateral symmetry , abnormal
Show

 ZFA:0001439 anatomical system anatomical system quality , abnormal
Show

 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage morphology , abnormal
Show

 ZFA:0001486 epithelium epithelium disorganized , abnormal
Show

 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage decreased amount , abnormal
Show

 ZFA:0001580 neurocranium neurocranium posterior region absent , abnormal
neurocranium absent , abnormal
neurocranium posterior region morphology , abnormal
neurocranium posterior region hypoplastic , abnormal
Show

 ZFA:0001613 pharyngeal arch 3-7 pharyngeal arch 3-7 morphology , abnormal
Show

 ZFA:0005886 anterior basicapsular commissure anterior basicapsular commissure absent , abnormal
Show

 ZFA:0005887 posterior basicapsular commissure posterior basicapsular commissure absent , abnormal
Show

 ZFA:0005888 lateral basicapsular commissure lateral basicapsular commissure absent , abnormal
Show

 ZFA:0007032 midbrain neural rod midbrain neural rod morphology , abnormal
midbrain neural rod increased thickness , abnormal
midbrain neural rod prominent , abnormal
Show

 ZFA:0007046 midbrain hindbrain boundary neural rod midbrain hindbrain boundary neural rod morphology , abnormal
Show

 ZFA:0009027 chondroblast chondroblast absent , abnormal
Show

 ZFA:0009084 chondrocyte chondrocyte absent , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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