ENSDARG00000018124


Danio rerio

Features
Gene ID: ENSDARG00000018124
  
Biological name :psmd3
  
Synonyms : proteasome 26S subunit, non-ATPase 3 / psmd3
  
Possible biological names infered from orthology : 26S proteasome non-ATPase regulatory subunit 3 / O43242 / P14685
  
Species: Danio rerio
  
Chr. number: 19
Strand: 1
Band:
Gene start: 48049202
Gene end: 48059334
  
Corresponding Affymetrix probe sets: Dr.13797.1.S1_at (Zebrafish Array)   NM_200572_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000025779
NCBI entrez gene - 393544     See in Manteia.
RefSeq - NM_200572
RefSeq Peptide - NP_956866
swissprot - Q6NYV1
ZFIN ID - ZDB-GENE-040426-1444
Ensembl - ENSDARG00000018124
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PSMD3ENSGALG00000033162Gallus gallus
 PSMD3ENSG00000108344Homo sapiens
 Psmd3ENSMUSG00000017221Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000717  Proteasome component (PCI) domain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR011991  ArsR-like helix-turn-helix domain
 IPR013586  26S proteasome regulatory subunit, C-terminal
 IPR035267  26S proteasome non-ATPase regulatory subunit 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0007417 central nervous system development IMP
 biological_processGO:0007420 brain development IMP
 biological_processGO:0008345 larval locomotory behavior IMP
 biological_processGO:0042176 regulation of protein catabolic process IEA
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:0071599 otic vesicle development IMP
 cellular_componentGO:0000502 proteasome complex IEA
 cellular_componentGO:0008541 proteasome regulatory particle, lid subcomplex IBA
 molecular_functionGO:0030234 enzyme regulator activity IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Hedgehog on state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Neutrophil degranulation
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain morphology , abnormal
brain decreased size , abnormal
brain edematous , abnormal
Show

 ZFA:0000012 central nervous system central nervous system neuron irregular spatial pattern , abnormal
Show

 ZFA:0000022 floor plate floor plate absent , abnormal
Show

 ZFA:0000051 otic vesicle otic vesicle decreased size , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000217 inner ear inner ear decreased size , abnormal
Show

 ZFA:0001114 head head morphology , abnormal
head decreased size , abnormal
Show

 ZFA:0001115 trunk trunk curved ventral , abnormal
Show

 ZFA:0001617 otolith otolith decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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