ENSDARG00000077815


Danio rerio

Features
Gene ID: ENSDARG00000077815
  
Biological name :cdc26
  
Synonyms : cdc26 / cell division cycle 26 homolog / Q68EK9
  
Possible biological names infered from orthology : Anaphase-promoting complex subunit CDC26 / cell division cycle 26 / Q8NHZ8 / Q99JP4
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 57359542
Gene end: 57361594
  
Corresponding Affymetrix probe sets: Dr.15299.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000100739
NCBI entrez gene - 445501     See in Manteia.
RefSeq - NM_001004005
RefSeq Peptide - NP_001004005
swissprot - Q68EK9
ZFIN ID - ZDB-GENE-040822-18
Ensembl - ENSDARG00000077815
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CDC26ENSGALG00000026095Gallus gallus
 CDC26ENSG00000176386Homo sapiens
 Cdc26ENSMUSG00000066149Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR018860  Anaphase-promoting complex, subunit CDC26


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030071 regulation of mitotic metaphase/anaphase transition IEA
 biological_processGO:0031145 anaphase-promoting complex-dependent catabolic process IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0070979 protein K11-linked ubiquitination ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005680 anaphase-promoting complex ISS
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000208 gall bladder gall bladder morphology , abnormal
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 ZFA:0001094 whole organism whole organism apoptotic , abnormal
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 ZFA:0001249 exocrine pancreas exocrine pancreas decreased length , abnormal
exocrine pancreas degenerate , abnormal
exocrine pancreas retracted , abnormal
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 ZFA:0001289 ciliary marginal zone ciliary marginal zone decreased size , abnormal
ciliary marginal zone spindle orientation retinal pigmented epithelium , abnormal
ciliary marginal zone spindle structure , abnormal
ciliary marginal zone spindle increased amount , abnormal
ciliary marginal zone spindle apical-basal polarity , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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