ENSDARG00000091085


Danio rerio

Features
Gene ID: ENSDARG00000091085
  
Biological name :lepa
  
Synonyms : lepa / leptin a
  
Possible biological names infered from orthology :
  
Species: Danio rerio
  
Chr. number: 18
Strand: 1
Band:
Gene start: 10689772
Gene end: 10690365
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000111103
NCBI entrez gene - 100150233     See in Manteia.
RefSeq - NM_001128576
RefSeq Peptide - NP_001122048
swissprot - Q0D250
ZFIN ID - ZDB-GENE-081001-1
Ensembl - ENSDARG00000091085
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
lepb / leptin bENSDARG0000004554820


Protein motifs (from Interpro)
Interpro ID Name
 IPR000065  Leptin
 IPR009079  Four-helical cytokine-like, core


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006112 energy reserve metabolic process IBA
 biological_processGO:0006629 lipid metabolic process IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007260 tyrosine phosphorylation of STAT protein IBA
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IBA
 biological_processGO:0032008 positive regulation of TOR signaling IBA
 biological_processGO:0032868 response to insulin IBA
 biological_processGO:0038108 negative regulation of appetite by leptin-mediated signaling pathway IBA
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0048839 inner ear development IMP
 biological_processGO:1900745 positive regulation of p38MAPK cascade IBA
 biological_processGO:1990051 activation of protein kinase C activity IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005179 hormone activity IBA
 molecular_functionGO:0051428 peptide hormone receptor binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000006 ball ball increased circumference , abnormal
Show

 ZFA:0000008 brain brain dorsal region physical object quality , abnormal
Show

 ZFA:0000024 retinal ganglion cell layer retinal ganglion cell layer decreased size , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000084 yolk yolk present , abnormal
yolk increased size , abnormal
Show

 ZFA:0000100 cerebellum cerebellum dorsal region morphology , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000140 pancreas pancreas has extra parts of type pancreatic B cell , abnormal
Show

 ZFA:0000431 semicircular canal semicircular canal hypoplastic , abnormal
Show

 ZFA:0000435 cranial nerve II cranial nerve II decreased thickness , abnormal
Show

 ZFA:0000445 optic tectum optic tectum postero-dorsal region morphology , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased size , abnormal
whole organism decreased pigmentation , abnormal
Show

 ZFA:0001115 trunk trunk kinked , abnormal
Show

 ZFA:0001117 post-vent region post-vent region kinked , abnormal
Show

 ZFA:0001617 otolith otolith decreased size , abnormal
Show

 ZFA:0009247 secondary motor neuron secondary motor neuron axon branchiness , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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