ENSG00000040275


Homo sapiens

Features
Gene ID: ENSG00000040275
  
Biological name :SPDL1
  
Synonyms : Q96EA4 / SPDL1 / spindle apparatus coiled-coil protein 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q35.1
Gene start: 169583634
Gene end: 169604778
  
Corresponding Affymetrix probe sets: 221685_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000423687
Ensembl peptide - ENSP00000486653
Ensembl peptide - ENSP00000429470
Ensembl peptide - ENSP00000427510
Ensembl peptide - ENSP00000427197
Ensembl peptide - ENSP00000426965
Ensembl peptide - ENSP00000426881
Ensembl peptide - ENSP00000425922
Ensembl peptide - ENSP00000425357
Ensembl peptide - ENSP00000265295
Ensembl peptide - ENSP00000421598
Ensembl peptide - ENSP00000422352
NCBI entrez gene - 54908     See in Manteia.
OMIM - 616401
RefSeq - XM_017009602
RefSeq - NM_001329641
RefSeq - NM_017785
RefSeq - XM_011534585
RefSeq - XM_011534586
RefSeq - XM_011534587
RefSeq - XM_011534588
RefSeq - XM_011534589
RefSeq - XM_011534590
RefSeq - XM_017009601
RefSeq Peptide - NP_060255
RefSeq Peptide - NP_001316570
swissprot - D6RDK5
swissprot - D6RCL1
swissprot - D6RC83
swissprot - D6R936
swissprot - D6RIB8
swissprot - H0YBG5
swissprot - H7C5V2
swissprot - D6RIF7
swissprot - Q96EA4
swissprot - D6REZ1
Ensembl - ENSG00000040275
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spdl1ENSDARG00000103996Danio rerio
 SPDL1ENSGALG00000001942Gallus gallus
 Spdl1ENSMUSG00000069910Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR028593  Protein Spindly, chordates


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000132 establishment of mitotic spindle orientation IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0007080 mitotic metaphase plate congression IMP
 biological_processGO:0031577 spindle checkpoint IEA
 biological_processGO:0034501 protein localization to kinetochore IMP
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0000940 condensed chromosome outer kinetochore IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0043515 kinetochore binding IDA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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