ENSG00000078237


Homo sapiens

Features
Gene ID: ENSG00000078237
  
Biological name :TIGAR
  
Synonyms : Q9NQ88 / TIGAR / TP53 induced glycolysis regulatory phosphatase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: p13.32
Gene start: 4307763
Gene end: 4354593
  
Corresponding Affymetrix probe sets: 219099_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000179259
Ensembl peptide - ENSP00000488928
NCBI entrez gene - 57103     See in Manteia.
OMIM - 610775
RefSeq - NM_020375
RefSeq Peptide - NP_065108
swissprot - A0A0U1RQD1
swissprot - Q9NQ88
Ensembl - ENSG00000078237
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q29RA5ENSDARG00000051749Danio rerio
 tigarbENSDARG00000045858Danio rerio
 TIGARENSGALG00000026776Gallus gallus
 TigarENSMUSG00000038028Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001345  Phosphoglycerate/bisphosphoglycerate mutase, active site
 IPR013078  Histidine phosphatase superfamily, clade-1
 IPR029033  Histidine phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002931 response to ischemia IEA
 biological_processGO:0006003 fructose 2,6-bisphosphate metabolic process IEA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IDA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009410 response to xenobiotic stimulus IEA
 biological_processGO:0010332 response to gamma radiation IEA
 biological_processGO:0010666 positive regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0030388 fructose 1,6-bisphosphate metabolic process IDA
 biological_processGO:0043069 negative regulation of programmed cell death IDA
 biological_processGO:0043456 regulation of pentose-phosphate shunt IMP
 biological_processGO:0045739 positive regulation of DNA repair IMP
 biological_processGO:0045820 negative regulation of glycolytic process IEA
 biological_processGO:0060576 intestinal epithelial cell development IEA
 biological_processGO:0071279 cellular response to cobalt ion IDA
 biological_processGO:0071456 cellular response to hypoxia IDA
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1901525 negative regulation of mitophagy IEA
 biological_processGO:1902153 regulation of response to DNA damage checkpoint signaling IMP
 biological_processGO:1903301 positive regulation of hexokinase activity IDA
 biological_processGO:1904024 negative regulation of glucose catabolic process to lactate via pyruvate IEA
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IEA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IDA
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004083 bisphosphoglycerate 2-phosphatase activity IDA
 molecular_functionGO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity EXP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
TP53 Regulates Metabolic Genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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